General Structure Information
| PDB ID | 4lg8 |
| HGNC Gene Label(s) | PRPF19 |
| Structure Name | crystal structure of prpf19 wd40 repeats |
| Resolution | 1.89Å |
| Reference | AUTH C.XU,W.TEMPEL,H.HE,E.DOBROVETSKY,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,J.MIN,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF PRPF19 WD40 REPEATSREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 310 |
| Number Of SNVs | 34 |
| Number Of Permutations | 3292 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.061 |
| p-value | 0.702 |
COSMIC
| Number Of Residues | 310 |
| Number Of SNVs | 3 |
| Number Of Permutations | 107 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.333 |
| p-value | 0.116 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 34 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.317 |
| p-value | 0.384 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
