General Structure Information
| PDB ID | 3hve |
| HGNC Gene Label(s) | GAN |
| Structure Name | structures of spop-substrate complexes: insights into molecular architectures of btb-cul3 ubiquitin ligases: gigaxoninbtb/3-box |
| Resolution | 2.8Å |
| Reference | AUTH M.ZHUANG,M.F.CALABRESE,J.LIU,M.B.WADDELL,A.NOURSE,AUTH 2 M.HAMMEL,D.J.MILLER,H.WALDEN,D.M.DUDA,S.N.SEYEDIN,AUTH 3 T.HOGGARD,J.W.HARPER,K.P.WHITE,B.A.SCHULMANTITL STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTSTITL 2 INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITINTITL 3 LIGASES.REF MOL.CELL V. 36 39 2009REFN ISSN 1097-2765PMID 19818708DOI 10.1016/J.MOLCEL.2009.09.022 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 211 |
| Number Of SNVs | 53 |
| Number Of Permutations | 13115 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.124 |
| p-value | 0.096 |
ClinVar
| Number Of Residues | 211 |
| Number Of SNVs | 3 |
| Number Of Permutations | 273 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.333 |
| p-value | 0.793 |
COSMIC
| Number Of Residues | 211 |
| Number Of SNVs | 4 |
| Number Of Permutations | 828 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.333 |
| p-value | 0.61 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 53 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.247 |
| p-value | 0.637 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 53 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.263 |
| p-value | 0.682 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
