Assessment of Structural Intolerance and Durability
General Structure Information 3a1b DNMT3A crystal structure of the dnmt3a add domain in complex with histone h3 2.29Å AUTH J.OTANI,T.NANKUMO,K.ARITA,S.INAMOTO,M.ARIYOSHI,M.SHIRAKAWATITL STRUCTURAL BASIS FOR RECOGNITION OF H3K4 METHYLATION STATUSTITL 2 BY THE DNA METHYLTRANSFERASE 3A ATRX-DNMT3-DNMT3L DOMAINREF EMBO REP. V. 10 1235 2009REFN ISSN 1469-221XPMID 19834512DOI 10.1038/EMBOR.2009.218 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2pfn POLL na in the active site of dna polymerase lambda 1.9Å AUTH M.GARCIA-DIAZ,K.BEBENEK,J.M.KRAHN,L.C.PEDERSEN,AUTH 2 T.A.KUNKELTITL ROLE OF THE CATALYTIC METAL DURING POLYMERIZATIONTITL 2 BY DNA POLYMERASE LAMBDA.REF DNA REPAIR V. 6 1333 2007REFN ISSN 1568-7864PMID 17475573DOI 10.1016/J.DNAREP.2007.03.005 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3abd MAD2L2 structure of human rev7 in complex with a human rev3 fragment in a monoclinic crystal 1.9Å AUTH K.HARA,H.HASHIMOTO,Y.MURAKUMO,S.KOBAYASHI,T.KOGAME,S.UNZAI,AUTH 2 S.AKASHI,S.TAKEDA,T.SHIMIZU,M.SATOTITL CRYSTAL STRUCTURE OF HUMAN REV7 IN COMPLEX WITH A HUMAN REV3TITL 2 FRAGMENT AND STRUCTURAL IMPLICATION OF THE INTERACTIONTITL 3 BETWEEN DNA POLYMERASE {ZETA} AND REV1REF J.BIOL.CHEM. V. 285 12299 […]
General Structure Information 3gqc REV1 structure of human rev1-dna-dntp ternary complex 2.5Å AUTH M.K.SWAN,R.E.JOHNSON,L.PRAKASH,S.PRAKASH,A.K.AGGARWALTITL STRUCTURE OF THE HUMAN REV1-DNA-DNTP TERNARY COMPLEX.REF J.MOL.BIOL. V. 390 699 2009REFN ISSN 0022-2836PMID 19464298DOI 10.1016/J.JMB.2009.05.026 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2i7t CPSF3 structure of human cpsf-73 2.1Å AUTH C.R.MANDEL,S.KANEKO,H.ZHANG,D.GEBAUER,V.VETHANTHAM,AUTH 2 J.L.MANLEY,L.TONGTITL POLYADENYLATION FACTOR CPSF-73 IS THE PRE-MRNATITL 2 3-END-PROCESSING ENDONUCLEASE.REF NATURE V. 444 953 2006REFN ISSN 0028-0836PMID 17128255DOI 10.1038/NATURE05363 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3gv7 POLI human dna polymerase iota in complex with t template dna and incoming dttp 2.2Å AUTH K.N.KIROUAC,H.LINGTITL STRUCTURAL BASIS OF ERROR-PRONE REPLICATION AND STALLING ATTITL 2 A THYMINE BASE BY HUMAN DNA POLYMERASE IOTAREF EMBO J. V. 28 1644 2009REFN ISSN 0261-4189PMID 19440206DOI 10.1038/EMBOJ.2009.122 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3in5 POLK structure of human dna polymerase kappa inserting datp opposite an 8-oxog dna lesion 3.2Å AUTH R.VASQUEZ-DEL CARPIO,T.D.SILVERSTEIN,S.LONE,AUTH 2 M.K.SWAN,J.R.CHOUDHURY,R.E.JOHNSON,S.PRAKASH,AUTH 3 L.PRAKASH,A.K.AGGARWALTITL STRUCTURE OF HUMAN DNA POLYMERASE KAPPA INSERTINGTITL 2 DATP OPPOSITE AN 8-OXOG DNA LESIONREF PLOS ONE V. 4 E5766 2009REFN ESSN 1932-6203PMID 19492058DOI 10.1371/JOURNAL.PONE.0005766 Variant Set Distributions Pathogenic Proximity […]
General Structure Information 1×51 MUTYH solution structure of the nudix domain from human a/g- specific adenine dna glycosylase alpha-3 splice isoform -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE NUDIX DOMAIN FROM HUMANTITL 2 A/G-SPECIFIC ADENINE DNA GLYCOSYLASE ALPHA-3TITL 3 SPLICE ISOFORMREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2jw5 POLL polymerase lambda brct domain -1.0Å AUTH G.A.MUELLER,A.F.MOON,E.F.DEROSE,B.J.DAVIS,AUTH 2 D.A.RAMSDEN,L.C.PEDERSEN,R.E.LONDONTITL POLYMERASE LAMBDA BRCT DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4m0a POLM human dna polymerase mu post-catalytic complex 1.85Å AUTH A.F.MOON,J.M.PRYOR,D.A.RAMSDEN,T.A.KUNKEL,K.BEBENEK,AUTH 2 L.C.PEDERSENTITL SUSTAINED ACTIVE SITE RIGIDITY DURING SYNTHESIS BY HUMAN DNATITL 2 POLYMERASE MU.REF NAT.STRUCT.MOL.BIOL. V. 21 253 2014REFN ISSN 1545-9993PMID 24487959DOI 10.1038/NSMB.2766 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants