Assessment of Structural Intolerance and Durability
General Structure Information 3iv1 TSG101 coiled-coil domain of tumor susceptibility gene 101 2.5Å AUTH D.NECULAI,G.V.AVVAKUMOV,A.K.WERNIMONT,S.XUE,AUTH 2 J.R.WALKER,Y.LI,J.WEIGELT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL COILED-COIL DOMAIN OF HUMAN TSG101REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3egi TGS1 methyltransferase domain of human trimethylguanosine synthase tgs1 bound to m7gpppa (inactive form) 2.21Å AUTH T.MONECKE,A.DICKMANNS,A.STRASSER,R.FICNERTITL STRUCTURE ANALYSIS OF THE CONSERVED METHYLTRANSFERASE DOMAINTITL 2 OF HUMAN TRIMETHYLGUANOSINE SYNTHASE TGS1.REF ACTA CRYSTALLOGR.,SECT.D V. 65 332 2009REFN ISSN 0907-4449PMID 19307714DOI 10.1107/S0907444909003102 Variant Set Distributions Mapped Variants
General Structure Information 3omk NR1H4 crystal structure of human fxr in complex with (2s)-2-[2-(4- chlorophenyl)-5,6-difluoro-1h-benzimidazol-1-yl]-2-cyclohexyl-n-(2- methylphenyl)ethanamide 1.9Å AUTH H.G.F.RICHTER,G.M.BENSON,K.H.BLEICHER,D.BLUM,E.CHAPUT,AUTH 2 N.CLEMANN,S.FENG,C.GARDES,U.GRETHER,P.HARTMAN,B.KUHN,AUTH 3 R.E.MARTIN,J.M.PLANCHER,M.G.RUDOLPH,F.SCHULER,S.TAYLORTITL OPTIMIZATION OF A NOVEL CLASS OF BENZIMIDAZOLE-BASEDTITL 2 FARNESOID X RECEPTOR (FXR) AGONISTS TO IMPROVETITL 3 PHYSICOCHEMICAL AND ADME PROPERTIESREF BIOORG.MED.CHEM.LETT. V. 21 1134 2011REFN ISSN 0960-894XPMID 21269824DOI 10.1016/J.BMCL.2010.12.123 Variant Set Distributions […]
General Structure Information 3emw SPSB2 crystal structure of human spla/ryanodine receptor domain and socs box containing 2 (spsb2) in complex with a 20-residue vasa peptide 1.8Å AUTH P.FILIPPAKOPOULOS,A.LOW,T.D.SHARPE,J.UPPENBERG,S.YAO,AUTH 2 Z.KUANG,P.SAVITSKY,R.S.LEWIS,S.E.NICHOLSON,R.S.NORTON,AUTH 3 A.N.BULLOCKTITL STRUCTURAL BASIS FOR PAR-4 RECOGNITION BY THE SPRY DOMAIN-TITL 2 AND SOCS BOX-CONTAINING PROTEINS SPSB1, SPSB2, AND SPSB4.REF J.MOL.BIOL. V. 401 389 2010REFN […]
General Structure Information 3cuq VPS25 integrated structural and functional model of the human escrt-ii complex 2.61Å AUTH Y.J.IM,J.H.HURLEYTITL INTEGRATED STRUCTURAL MODEL AND MEMBRANE TARGETING MECHANISMTITL 2 OF THE HUMAN ESCRT-II COMPLEXREF DEV.CELL V. 14 902 2008REFN ISSN 1534-5807PMID 18539118DOI 10.1016/J.DEVCEL.2008.04.004 Variant Set Distributions Mapped Variants
General Structure Information 2ean CNKSR2 solution structure of the n-terminal sam-domain of human kiaa0902 protein (connector enhancer of kinase suppressor of ras 2) -1.0Å AUTH A.K.GORONCY,M.YONEYAMA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERMINAL SAM-DOMAIN OFTITL 2 HUMAN KIAA0902 PROTEIN (CONNECTOR ENHANCER OFTITL 3 KINASE SUPPRESSOR OF RAS 2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped […]
General Structure Information 2kje CREBBP nmr structure of cbp taz2 and adenoviral e1a complex -1.0Å AUTH J.C.FERREON,M.A.MARTINEZ-YAMOUT,H.J.DYSON,AUTH 2 P.E.WRIGHTTITL STRUCTURAL BASIS FOR SUBVERSION OF CELLULAR CONTROLTITL 2 MECHANISMS BY THE ADENOVIRAL E1A ONCOPROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 106 13260 2009REFN ISSN 0027-8424PMID 19651603DOI 10.1073/PNAS.0906770106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3me9 CCDC101 crystal structure of sgf29 in complex with h3k4me3 peptide 1.37Å AUTH C.BIAN,C.XU,J.RUAN,K.K.LEE,T.L.BURKE,W.TEMPEL,D.BARSYTE,AUTH 2 J.LI,M.WU,B.O.ZHOU,B.E.FLEHARTY,A.PAULSON,A.ALLALI-HASSANI,AUTH 3 J.Q.ZHOU,G.MER,P.A.GRANT,J.L.WORKMAN,J.ZANG,J.MINTITL SGF29 BINDS HISTONE H3K4ME2/3 AND IS REQUIRED FOR SAGATITL 2 COMPLEX RECRUITMENT AND HISTONE H3 ACETYLATION.REF EMBO J. V. 30 2829 2011REFN ISSN 0261-4189PMID 21685874DOI 10.1038/EMBOJ.2011.193 Variant Set Distributions Mapped Variants
General Structure Information 2ytw HTRA1 solution structure of the pdz-domain of human protease htra 1 precursor -1.0Å AUTH A.K.GORONCY,K.SAITO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PDZ-DOMAIN OF HUMANTITL 2 PROTEASE HTRA 1 PRECURSORREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3odx ARHGEF1 crystal structure of an n-terminally truncated linker-dh/ph domains of p115-rhogef 3.2Å AUTH Z.CHEN,L.GUO,S.R.SPRANG,P.C.STERNWEISTITL MODULATION OF A GEF SWITCH: AUTOINHIBITION OF THE INTRINSICTITL 2 GUANINE NUCLEOTIDE EXCHANGE ACTIVITY OF P115-RHOREFREF PROTEIN SCI. V. 20 107 2011REFN ISSN 0961-8368 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]