General Structure Information
| PDB ID | 3omk |
| HGNC Gene Label(s) | NR1H4 |
| Structure Name | crystal structure of human fxr in complex with (2s)-2-[2-(4- chlorophenyl)-5,6-difluoro-1h-benzimidazol-1-yl]-2-cyclohexyl-n-(2- methylphenyl)ethanamide |
| Resolution | 1.9Å |
| Reference | AUTH H.G.F.RICHTER,G.M.BENSON,K.H.BLEICHER,D.BLUM,E.CHAPUT,AUTH 2 N.CLEMANN,S.FENG,C.GARDES,U.GRETHER,P.HARTMAN,B.KUHN,AUTH 3 R.E.MARTIN,J.M.PLANCHER,M.G.RUDOLPH,F.SCHULER,S.TAYLORTITL OPTIMIZATION OF A NOVEL CLASS OF BENZIMIDAZOLE-BASEDTITL 2 FARNESOID X RECEPTOR (FXR) AGONISTS TO IMPROVETITL 3 PHYSICOCHEMICAL AND ADME PROPERTIESREF BIOORG.MED.CHEM.LETT. V. 21 1134 2011REFN ISSN 0960-894XPMID 21269824DOI 10.1016/J.BMCL.2010.12.123 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 229 |
| Number Of SNVs | 42 |
| Number Of Permutations | 6125 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.159 |
| p-value | 0.027 |
COSMIC
| Number Of Residues | 229 |
| Number Of SNVs | 3 |
| Number Of Permutations | 287 |
| Optimal Distance Threshold | 35.0 |
| K Statistic | 0.667 |
| p-value | 0.926 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
