Assessment of Structural Intolerance and Durability
General Structure Information 2m0c ALX4 solution nmr structure of homeobox domain of human alx4, northeast structural genomics consortium (nesg) target hr4490c -1.0Å AUTH X.XU,A.ELETSKY,S.PULAVARTI,D.LEE,H.JANJUA,R.XIAO,T.B.ACTON,AUTH 2 J.K.EVERETT,G.T.MONTELIONE,T.SZYPERSKITITL SOLUTION NMR STRUCTURE OF HOMEOBOX DOMAIN OF HUMAN ALX4,TITL 2 NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGETTITL 3 HR4490CREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2kk0 ARID3A solution structure of dead ringer-like protein 1 (at-rich interactive domain-containing protein 3a) from homo sapiens, northeast structural genomics consortium (nesg) target hr4394c -1.0Å AUTH G.LIU,Y.J.HUANG,R.XIAO,D.WANG,T.B.ACTON,G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF THE ARID DOMAIN OF HUMAN AT-RICHTITL 2 INTERACTIVE DOMAIN-CONTAINING PROTEIN 3A: A HUMAN CANCERTITL 3 PROTEIN INTERACTION NETWORK TARGET.REF PROTEINS V. […]
General Structure Information 3qrf FOXP3 structure of a domain-swapped foxp3 dimer 2.8Å AUTH H.S.BANDUKWALA,Y.WU,M.FEUERER,Y.CHEN,B.BARBOZA,S.GHOSH,AUTH 2 J.C.STROUD,C.BENOIST,D.MATHIS,A.RAO,L.CHENTITL STRUCTURE OF A DOMAIN-SWAPPED FOXP3 DIMER ON DNA AND ITSTITL 2 FUNCTION IN REGULATORY T CELLS.REF IMMUNITY V. 34 479 2011REFN ISSN 1074-7613PMID 21458306DOI 10.1016/J.IMMUNI.2011.02.017 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2x6u TBX5 crystal structure of human tbx5 in the dna-free form 1.9Å AUTH C.U.STIRNIMANN,D.PTCHELKINE,C.GRIMM,C.W.MULLERTITL STRUCTURAL BASIS OF TBX5-DNA RECOGNITION: THE T-TITL 2 BOX DOMAIN IN ITS DNA-BOUND AND -UNBOUND FORM.REF J.MOL.BIOL. V. 400 71 2010REFN ISSN 0022-2836PMID 20450920DOI 10.1016/J.JMB.2010.04.052 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3ewf HDAC8 crystal structure analysis of human hdac8 h143a variant complexed with substrate. 2.5Å AUTH D.P.DOWLING,S.L.GANTT,S.G.GATTIS,C.A.FIERKE,AUTH 2 D.W.CHRISTIANSONTITL STRUCTURAL STUDIES OF HUMAN HISTONE DEACETYLASE 8TITL 2 AND ITS SITE-SPECIFIC VARIANTS COMPLEXED WITHTITL 3 SUBSTRATE AND INHIBITORS.REF BIOCHEMISTRY V. 47 13554 2008REFN ISSN 0006-2960PMID 19053282DOI 10.1021/BI801610C Variant Set Distributions Pathogenic Proximity Analysis Mapped […]
General Structure Information 1d5v FOXC2 solution structure of the forkhead domain of the adipocyte- transcription factor freac-11 (s12) -1.0Å AUTH M.J.VAN DONGEN,A.CEDERBERG,P.CARLSSON,S.ENERBACK,AUTH 2 M.WIKSTROMTITL SOLUTION STRUCTURE AND DYNAMICS OF THE DNA-BINDINGTITL 2 DOMAIN OF THE ADIPOCYTE-TRANSCRIPTION FACTORTITL 3 FREAC-11.REF J.MOL.BIOL. V. 296 351 2000REFN ISSN 0022-2836PMID 10669593DOI 10.1006/JMBI.1999.3476 Variant Set Distributions Mapped Variants
General Structure Information 2y33 EGLN1 s-nitrosylated phd2 (gsno soaked) in complex with zn(ii) and un9 2.0Å AUTH R.CHOWDHURY,E.FLASHMAN,J.MECINOVIC,H.B.KRAMER,B.M.KESSLER,AUTH 2 Y.M.FRAPART,J.-L.BOUCHER,I.J.CLIFTON,M.A.MCDONOUGH,AUTH 3 C.J.SCHOFIELDTITL STUDIES ON THE REACTION OF NITRIC OXIDE WITH THETITL 2 HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE DOMAIN 2TITL 3 (EGLN1)REF J.MOL.BIOL. V. 410 268 2011REFN ISSN 0022-2836PMID 21601578DOI 10.1016/J.JMB.2011.04.075 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3kvh NUDT16L1 crystal structure of human protein syndesmos (nudt16-like protein) 1.7Å AUTH L.TRESAUGUES,M.I.SIPONEN,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,A.KALLAS,AUTH 4 T.KARLBERG,T.KOTENYOVA,A.KOTZSCH,P.KRAULIS,M.MOCHE,AUTH 5 T.K.NIELSEN,T.NYMAN,C.PERSSON,A.K.ROOS,H.SCHULER,P.SCHUTZ,AUTH 6 A.G.THORSELL,S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WISNIEWSKA,AUTH 7 P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN PROTEIN SYNDESMOS (NUDT16L1)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3no8 BTBD2 crystal structure of the phr domain from human btbd2 protein 2.2Å AUTH P.SAMPATHKUMARTITL CRYSTAL STRUCTURE OF THE PHR DOMAIN FROM HUMAN BTBD2 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3oln UHRF2 crystal structure of the sra domain of e3 ubiquitin-protein ligase uhrf2 2.3Å AUTH J.R.WALKER,S.XUE,G.V.AVVAKUMOV,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANON,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL THE SET AND RING ASSOCIATED (SRA) DOMAIN OF HUMANTITL 2 UBIQUITIN-LIKE CONTAINING PHD AND RING FINGER DOMAINS 2TITL 3 (UHRF2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants