General Structure Information
| PDB ID | 2y33 |
| HGNC Gene Label(s) | EGLN1 |
| Structure Name | s-nitrosylated phd2 (gsno soaked) in complex with zn(ii) and un9 |
| Resolution | 2.0Å |
| Reference | AUTH R.CHOWDHURY,E.FLASHMAN,J.MECINOVIC,H.B.KRAMER,B.M.KESSLER,AUTH 2 Y.M.FRAPART,J.-L.BOUCHER,I.J.CLIFTON,M.A.MCDONOUGH,AUTH 3 C.J.SCHOFIELDTITL STUDIES ON THE REACTION OF NITRIC OXIDE WITH THETITL 2 HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE DOMAIN 2TITL 3 (EGLN1)REF J.MOL.BIOL. V. 410 268 2011REFN ISSN 0022-2836PMID 21601578DOI 10.1016/J.JMB.2011.04.075 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 215 |
| Number Of SNVs | 28 |
| Number Of Permutations | 4119 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.008 |
| p-value | 0.246 |
ClinVar
| Number Of Residues | 215 |
| Number Of SNVs | 3 |
| Number Of Permutations | 150 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 1.0 |
| p-value | 0.045 |
COSMIC
| Number Of Residues | 215 |
| Number Of SNVs | 3 |
| Number Of Permutations | 18 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.333 |
| p-value | 0.809 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 28 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.897 |
| p-value | 0.026 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 28 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.212 |
| p-value | 0.902 |