Assessment of Structural Intolerance and Durability
General Structure Information 2khx DROSHA drosha double-stranded rna binding motif -1.0Å AUTH G.A.MUELLER,M.T.MILLER,E.F.DEROSE,M.GHOSH,R.E.LONDON,AUTH 2 T.M.HALLTITL SOLUTION STRUCTURE OF THE DROSHA DOUBLE-STRANDED RNA-BINDINGTITL 2 DOMAIN.REF SILENCE V. 1 2 2010REFN ESSN 1758-907XPMID 20226070DOI 10.1186/1758-907X-1-2 Variant Set Distributions Mapped Variants
General Structure Information 2cpd A1CF solution structure of the rna recognition motif of human apobec-1 complementation factor, acf -1.0Å AUTH T.NAGATA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RNA RECOGNITION MOTIF OFTITL 2 HUMAN APOBEC-1 COMPLEMENTATION FACTOR, ACFREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2xml KDM4C crystal structure of human jmjd2c catalytic domain 2.55Å AUTH L.HILLRINGHAUS,W.W.YUE,N.R.ROSE,S.S.NG,C.GILEADI,C.LOENARZ,AUTH 2 S.H.BELLO,J.E.BRAY,C.J.SCHOFIELD,U.OPPERMANNTITL STRUCTURAL AND EVOLUTIONARY BASIS FOR THE DUAL SUBSTRATETITL 2 SELECTIVITY OF HUMAN KDM4 HISTONE DEMETHYLASE FAMILY.REF J.BIOL.CHEM. V. 286 41616 2011REFN ISSN 0021-9258PMID 21914792DOI 10.1074/JBC.M111.283689 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3f9y SETD8 structural insights into lysine multiple methylation by set domain methyltransferases, set8-y334f / h4-lys20me1 / adohcy 1.5Å AUTH J.F.COUTURE,L.M.DIRK,J.S.BRUNZELLE,R.L.HOUTZ,R.C.TRIEVELTITL STRUCTURAL ORIGINS FOR THE PRODUCT SPECIFICITY OF SET DOMAINTITL 2 PROTEIN METHYLTRANSFERASES.REF PROC.NATL.ACAD.SCI.USA V. 105 20659 2008REFN ISSN 0027-8424PMID 19088188DOI 10.1073/PNAS.0806712105 Variant Set Distributions Mapped Variants
General Structure Information 3c5h ARHGAP35 crystal structure of the ras homolog domain of human grlf1 (p190rhogap) 1.8Å AUTH L.SHEN,Y.TONG,W.TEMPEL,F.MACKENZIE,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RAS HOMOLOG DOMAIN OFTITL 2 HUMAN GRLF1 (P190RHOGAP).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3fk2 ARHGAP35 crystal structure of the rhogap domain of human glucocorticoid receptor dna-binding factor 1 2.8Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,P.LOPPNAU,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RHOGAP DOMAIN OF HUMANTITL 2 GLUCOCORTICOID RECEPTOR DNA-BINDING FACTOR 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2kiu FOXP1 solution structure and backbone dynamics of the dna-binding domain of foxp1: insight into its domain swapping -1.0Å AUTH Y.P.CHU,C.H.CHANG,J.H.SHIU,Y.T.CHANG,C.Y.CHEN,W.J.CHUANGTITL SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF THE DNA-BINDINGTITL 2 DOMAIN OF FOXP1: INSIGHT INTO ITS DOMAIN SWAPPING AND DNATITL 3 BINDING.REF PROTEIN SCI. V. 20 908 2011REFN ISSN 0961-8368PMID 21416545DOI 10.1002/PRO.626 […]
General Structure Information 4hpl PCGF1 pcgf1 ub fold (rawul)/bcor pufd complex 2.0Å AUTH S.E.JUNCO,R.WANG,J.C.GAIPA,A.B.TAYLOR,V.SCHIRF,M.D.GEARHART,AUTH 2 V.J.BARDWELL,B.DEMELER,P.J.HART,C.A.KIMTITL STRUCTURE OF THE POLYCOMB GROUP PROTEIN PCGF1 IN COMPLEXTITL 2 WITH BCOR REVEALS BASIS FOR BINDING SELECTIVITY OF PCGFTITL 3 HOMOLOGS.REF STRUCTURE V. 21 665 2013REFN ISSN 0969-2126PMID 23523425DOI 10.1016/J.STR.2013.02.013 Variant Set Distributions Mapped Variants
General Structure Information 1ll8 PASK structure and interactions of pas kinase n-terminal pas domain: model for intramolecular kinase regulation -1.0Å AUTH C.A.AMEZCUA,S.M.HARPER,J.RUTTER,K.H.GARDNERTITL STRUCTURE AND INTERACTIONS OF PAS KINASETITL 2 N-TERMINAL PAS DOMAIN: MODEL FOR INTRAMOLECULARTITL 3 KINASE REGULATION.REF STRUCTURE V. 10 1349 2002REFN ISSN 0969-2126PMID 12377121DOI 10.1016/S0969-2126(02)00857-2 Variant Set Distributions Mapped Variants
General Structure Information 1z6u UHRF2 np95-like ring finger protein isoform b [homo sapiens] 2.1Å AUTH J.R.WALKER,G.V.AVVAKUMOV,S.XUE,E.M.NEWMAN,AUTH 2 F.MACKENZIE,M.SUNDSTROM,C.ARROWSMITH,A.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANON,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL 2.1 ANGSTROM CRYSTAL STRUCTURE OF THE HUMANTITL 2 UBIQUITIN LIAGSE NIRFREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants