Assessment of Structural Intolerance and Durability
General Structure Information 3ray PRDM11 crystal structure of methyltransferase domain of human pr domain- containing protein 11 1.73Å AUTH A.DONG,H.ZENG,P.LOPPNAU,J.R.WALKER,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,H.WU,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMAN PRTITL 2 DOMAIN-CONTAINING PROTEIN 11REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2r3a SUV39H2 methyltransferase domain of human suppressor of variegation 3-9 homolog 2 2.0Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2vpk MYNN crystal structure of the btb domain of human myoneurin 2.0Å AUTH C.D.O.COOPER,J.W.MURRAY,A.BULLOCK,A.C.W.PIKE,AUTH 2 F.VON DELFT,P.FILIPPAKOPOULOS,E.SALAH,A.EDWARDS,AUTH 3 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,S.KNAPPTITL CRYSTAL STRUCTURE OF THE BTB DOMAIN OF HUMANTITL 2 MYONEURINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dl6 CHD8 solution structure of the first brk domain from human chromodomain-helicase-dna-binding protein 8 -1.0Å AUTH T.SUETAKE,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST BRK DOMAIN FROMTITL 2 HUMAN CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ep0 PRDM12 methyltransferase domain of human pr domain-containing protein 12 2.1Å AUTH H.ZENG,M.F.AMAYA,P.LOPPNAU,J.MIN,A.N.PLOTNIKOV,H.WUTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAINTITL 2 OF HUMAN PR DOMAIN-CONTAINING PROTEIN 12.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3q2e BRWD1 crystal structure of the second bromodomain of human bromodomain and wd repeat-containing protein 1 isoform a (wdr9) 1.74Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 3d8c HIF1AN factor inhibiting hif-1 alpha d201g mutant in complex with zn(ii), alpha-ketoglutarate and hif-1 alpha 19mer 2.1Å AUTH K.S.HEWITSON,S.L.HOLMES,D.EHRISMANN,A.P.HARDY,R.CHOWDHURY,AUTH 2 C.J.SCHOFIELD,M.A.MCDONOUGHTITL EVIDENCE THAT TWO ENZYME-DERIVED HISTIDINE LIGANDS ARETITL 2 SUFFICIENT FOR IRON BINDING AND CATALYSIS BY FACTORTITL 3 INHIBITING HIF (FIH).REF J.BIOL.CHEM. V. 283 25971 2008REFN ISSN 0021-9258PMID 18611856DOI 10.1074/JBC.M804999200 Variant […]
General Structure Information 2dkz GAREM solution structure of the sam_pnt-domain of the hypothetical protein loc64762 -1.0Å AUTH A.K.GORONCY,M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SAM_PNT-DOMAIN OF THETITL 2 HYPOTHETICAL PROTEIN LOC64762REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2rmn TP63 the solution structure of the p63 dna-binding domain -1.0Å AUTH A.ENTHART,J.FURRER,A.DEHNER,H.KESSLERTITL SOLUTION STRUCTURE AND BINDING STUDIES OF THE P63TITL 2 DNA BINDING DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ihx PRDM10 methyltransferase domain of human pr domain-containing protein 10 2.5Å AUTH M.F.AMAYA,L.DOMBROVSKI,S.NI,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOTCHKAREV,J.MIN,A.N.PLOTNIKOV,AUTH 3 H.WU,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL METHYLTRANSFERASE DOMAIN OF HUMAN PR DOMAIN-CONTAININGTITL 2 PROTEIN 10REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants