Assessment of Structural Intolerance and Durability
General Structure Information 2k40 HESX1 nmr structure of hesx-1 homeodomain double mutant r31l/e42l -1.0Å AUTH J.ASENSIO,M.TORRADO,C.GONZALEZ,A.BASTIDA,F.CORZANATITL THE ROLE OF CONSERVED SALT-BRIDGES ON HOMEODOMAINTITL 2 STABILITYREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2q87 CD300A the crystal structure of the human irp60 ectodomain 1.7Å AUTH N.DIMASI,J.A.MARQUEZTITL THE CRYSTAL STRUCTURE OF IRP60 ECTODOMAINREF TO BE PUBLISHED 2007REFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1d9n MBD1 solution structure of the methyl-cpg-binding domain of the methylation-dependent transcriptional repressor mbd1/pcm1 -1.0Å AUTH I.OHKI,N.SHIMOTAKE,N.FUJITA,M.NAKAO,M.SHIRAKAWATITL SOLUTION STRUCTURE OF THE METHYL-CPG-BINDINGTITL 2 DOMAIN OF THE METHYLATION-DEPENDENTTITL 3 TRANSCRIPTIONAL REPRESSOR MBD1.REF EMBO J. V. 18 6653 1999REFN ISSN 0261-4189PMID 10581239DOI 10.1093/EMBOJ/18.23.6653 Variant Set Distributions Mapped Variants
General Structure Information 3lyr EBF1 human early b-cell factor 1 (ebf1) dna-binding domain 2.51Å AUTH M.I.SIPONEN,M.WISNIEWSKA,L.LEHTIO,I.JOHANSSON,L.SVENSSON,AUTH 2 G.RASZEWSKI,L.NILSSON,M.SIGVARDSSON,H.BERGLUNDTITL STRUCTURAL DETERMINATION OF FUNCTIONAL DOMAINS IN EARLYTITL 2 B-CELL FACTOR (EBF) FAMILY OF TRANSCRIPTION FACTORS REVEALSTITL 3 SIMILARITIES TO REL DNA-BINDING PROTEINS AND A NOVELTITL 4 DIMERIZATION MOTIF.REF J.BIOL.CHEM. V. 285 25875 2010REFN ISSN 0021-9258PMID 20592035DOI 10.1074/JBC.C110.150482 […]
General Structure Information 3i3t USP21 crystal structure of covalent ubiquitin-usp21 complex 2.59Å AUTH A.ERNST,G.AVVAKUMOV,J.TONG,Y.FAN,Y.ZHAO,P.ALBERTS,A.PERSAUD,AUTH 2 J.R.WALKER,A.M.NECULAI,D.NECULAI,A.VOROBYOV,P.GARG,L.BEATTY,AUTH 3 P.K.CHAN,Y.C.JUANG,M.C.LANDRY,C.YEH,E.ZEQIRAJ,K.KARAMBOULAS,AUTH 4 A.ALLALI-HASSANI,M.VEDADI,M.TYERS,J.MOFFAT,F.SICHERI,AUTH 5 L.PELLETIER,D.DUROCHER,B.RAUGHT,D.ROTIN,J.YANG,M.F.MORAN,AUTH 6 S.DHE-PAGANON,S.S.SIDHUTITL A STRATEGY FOR MODULATION OF ENZYMES IN THE UBIQUITINTITL 2 SYSTEM.REF SCIENCE V. 339 590 2013REFN ISSN 0036-8075PMID 23287719DOI 10.1126/SCIENCE.1230161 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3db5 PRDM4 crystal structure of methyltransferase domain of human pr domain- containing protein 4 2.15Å AUTH H.ZENG,M.F.AMAYA,P.LOPPNAU,A.BOCHKAREV,J.MIN,A.N.PLOTNIKOV,AUTH 2 H.WUTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMANTITL 2 PR DOMAIN-CONTAINING PROTEIN 4.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4c0d CNOT2 structure of the not module of the human ccr4-not complex (cnot1-cnot2-cnot3) 3.2Å AUTH A.BOLAND,Y.CHEN,T.RAISCH,S.JONAS,D.KUZUOGLU-OZTURK,AUTH 2 L.WOHLBOLD,O.WEICHENRIEDER,E.IZAURRALDETITL STRUCTURE AND ASSEMBLY OF THE NOT MODULE OF THE HUMANTITL 2 CCR4-NOT COMPLEXREF NAT.STRUCT.MOL.BIOL. V. 20 1289 2013REFN ISSN 1545-9993PMID 24121232DOI 10.1038/NSMB.2681 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2kt0 NANOG solution structure of human stem cell transcription factor nanog homeodomain fragment -1.0Å AUTH S.C.SAHU,J.L.MARKLEYTITL SOLUTION STRUCTURE OF HUMAN STEM CELL TRANSCRIPTION FACTORTITL 2 NANOGREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4fo0 ACTR8 human actin-related protein arp8 in its atp-bound state 2.6Å AUTH C.B.GERHOLD,D.D.WINKLER,K.LAKOMEK,F.U.SEIFERT,S.FENN,AUTH 2 B.KESSLER,G.WITTE,K.LUGER,K.P.HOPFNERTITL STRUCTURE OF ACTIN-RELATED PROTEIN 8 AND ITS CONTRIBUTION TOTITL 2 NUCLEOSOME BINDING.REF NUCLEIC ACIDS RES. V. 40 11036 2012REFN ISSN 0305-1048PMID 22977180DOI 10.1093/NAR/GKS842 Variant Set Distributions Mapped Variants
General Structure Information 4b86 MSL2 crystal structure of the msl1-msl2 complex (3.5a) 3.5Å AUTH E.HALLACLI,M.LIPP,P.GEORGIEV,C.SPIELMAN,S.CUSACK,A.AKHTAR,AUTH 2 J.KADLECTITL MSL1-MEDIATED DIMERIZATION OF THE DOSAGE COMPENSATIONTITL 2 COMPLEX IS ESSENTIAL FOR MALE X-CHROMOSOME REGULATION INTITL 3 DROSOPHILA.REF MOL.CELL V. 48 587 2012REFN ISSN 1097-2765PMID 23084835DOI 10.1016/J.MOLCEL.2012.09.014 Variant Set Distributions Mapped Variants