General Structure Information
| PDB ID | 4fo0 |
| HGNC Gene Label(s) | ACTR8 |
| Structure Name | human actin-related protein arp8 in its atp-bound state |
| Resolution | 2.6Å |
| Reference | AUTH C.B.GERHOLD,D.D.WINKLER,K.LAKOMEK,F.U.SEIFERT,S.FENN,AUTH 2 B.KESSLER,G.WITTE,K.LUGER,K.P.HOPFNERTITL STRUCTURE OF ACTIN-RELATED PROTEIN 8 AND ITS CONTRIBUTION TOTITL 2 NUCLEOSOME BINDING.REF NUCLEIC ACIDS RES. V. 40 11036 2012REFN ISSN 0305-1048PMID 22977180DOI 10.1093/NAR/GKS842 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 500 |
| Number Of SNVs | 119 |
| Number Of Permutations | 54675 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.142 |
| p-value | 0.094 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 3:53914115 | I>V | A:49 | (-45.60, 8.19, -29.92) | |
| 3:53914104 | H>Q | A:52 | (-37.78, 12.60, -22.67) | |
| 3:53914106 | H>Y | A:52 | (-37.78, 12.60, -22.67) | |
| 3:53914093 | rs3733082 | T>I | A:56 | (-40.48, 16.75, -12.95) |
| 3:53914082 | I>F | A:60 | (-45.57, 12.83, -24.86) | |
| 3:53914058 | P>A | A:68 | (-43.81, 18.44, -27.03) | |
| 3:53914055 | rs201806411 | A>S | A:69 | (-46.48, 17.47, -24.35) |
| 3:53914051 | rs201757378 | S>N | A:70 | (-45.36, 19.11, -21.09) |
| 3:53914046 | rs560149594 | P>T | A:72 | (-46.62, 17.05, -14.68) |
| 3:53914040 | rs149728050 | V>I | A:74 | (-47.31, 13.28, -11.00) |
| 3:53914030 | COSM731852 | R>P | A:77 | (-52.97, 6.13, -7.10) |
| 3:53914009 | rs143916272 | Q>P | A:84 | (-54.96, 5.18, 4.62) |
| 3:53912491 | P>A | A:100 | (-24.12, 15.84, 11.45) | |
| 3:53912484 | S>N | A:102 | (-24.82, 19.03, 6.43) | |
| 3:53912472 | R>K | A:106 | (-25.02, 23.56, 3.76) | |
| 3:53912466 | rs557885296 | N>S | A:108 | (-17.14, 24.96, 3.77) |
| 3:53912438 | I>M | A:117 | (-18.03, 35.30, -7.02) | |
| 3:53912418 | rs143290220 | N>S | A:124 | (-15.23, 47.29, -15.02) |
| 3:53912407 | rs374119128 | R>C | A:128 | (-19.73, 40.99, -7.49) |
| 3:53912400 | P>L | A:130 | (-19.72, 42.28, -1.58) | |
| 3:53912388 | E>A | A:134 | (-27.17, 40.97, 8.21) | |
| 3:53912384 | COSM3596392 | Q>H | A:135 | (-28.38, 45.74, 5.07) |
| 3:53911774 | rs149202945 | R>H | A:137 | (-31.93, 39.83, 7.72) |
| 3:53911775 | rs200175322 | R>C | A:137 | (-31.93, 39.83, 7.72) |
| 3:53911765 | N>I | A:140 | (-36.84, 42.25, 3.52) | |
| 3:53911744 | I>T | A:147 | (-54.28, 42.37, -1.61) | |
| 3:53911737 | COSM4119378 | D>E | A:149 | (-57.21, 39.78, -6.29) |
| 3:53911738 | D>G | A:149 | (-57.21, 39.78, -6.29) | |
| 3:53911729 | S>L | A:152 | (-56.01, 33.41, -6.14) | |
| 3:53911715 | rs150103066 | T>A | A:157 | (-58.24, 19.36, -7.86) |
| 3:53911699 | H>L | A:162 | (-64.81, 10.28, -4.39) | |
| 3:53911691 | Y>D | A:165 | (-56.42, 7.99, -11.69) | |
| 3:53911688 | L>I | A:166 | (-55.62, 12.74, -10.04) | |
| 3:53911414 | rs368123625 | A>S | A:171 | (-52.00, 16.09, -8.94) |
| 3:53911383 | rs151232340 | N>S | A:181 | (-51.03, 8.89, -1.55) |
| 3:53911376 | rs148652386 | H>Q | A:183 | (-47.04, 8.37, -5.74) |
| 3:53911373 | W>C | A:184 | (-43.27, 13.26, -8.40) | |
| 3:53911364 | rs374069703 | R>S | A:187 | (-37.70, 11.43, -8.18) |
| 3:53911365 | R>K | A:187 | (-37.70, 11.43, -8.18) | |
| 3:53911349 | N>K | A:192 | (-39.24, 6.28, -6.91) | |
| 3:53911347 | I>T | A:193 | (-37.78, 1.92, -5.93) | |
| 3:53911348 | I>F | A:193 | (-37.78, 1.92, -5.93) | |
| 3:53911342 | P>S | A:195 | (-39.85, 2.15, 1.28) | |
| 3:53911317 | A>V | A:203 | (-46.19, 0.41, -8.60) | |
| 3:53911303 | I>V | A:208 | (-45.40, 4.98, -15.64) | |
| 3:53911287 | S>C | A:213 | (-52.05, 6.33, -20.89) | |
| 3:53911272 | K>R | A:218 | (-56.21, 14.78, -21.89) | |
| 3:53910716 | rs377008426 | P>T | A:237 | (-31.23, 7.01, -19.45) |
| 3:53910712 | D>G | A:238 | (-26.31, 7.89, -21.11) | |
| 3:53910709 | I>N | A:239 | (-26.05, 5.78, -17.12) | |
| 3:53910692 | rs372463670 | V>L | A:245 | (-35.37, -0.58, -19.91) |
| 3:53910677 | N>H | A:250 | (-43.21, -5.45, -21.28) | |
| 3:53910670 | I>T | A:252 | (-44.69, 0.19, -24.42) | |
| 3:53910667 | L>P | A:253 | (-44.75, -3.66, -26.72) | |
| 3:53910660 | K>N | A:255 | (-49.14, -3.99, -20.09) | |
| 3:53910096 | H>N | A:264 | (-31.41, 5.73, -28.63) | |
| 3:53910078 | A>P | A:270 | (-29.51, 15.57, -28.29) | |
| 3:53910074 | T>S | A:271 | (-26.86, 14.88, -30.84) | |
| 3:53910063 | G>S | A:275 | (-26.67, 18.82, -35.18) | |
| 3:53910050 | rs111613351 | T>M | A:279 | (-20.82, 16.80, -28.75) |
| 3:53910042 | rs191702927 | V>L | A:282 | (-24.58, 18.60, -20.49) |
| 3:53910035 | V>A | A:284 | (-29.09, 20.07, -16.48) | |
| 3:53910033 | G>W | A:285 | (-32.12, 18.81, -14.66) | |
| 3:53910028 | D>E | A:286 | (-35.18, 19.02, -11.39) | |
| 3:53910015 | rs375966881 | V>I | A:291 | (-21.73, 14.21, -18.61) |
| 3:53910008 | C>Y | A:293 | (-18.74, 12.10, -25.10) | |
| 3:53909984 | R>Q | A:301 | (-20.11, 2.18, -22.02) | |
| 3:53909985 | COSM170466 COSM170467 |
R>W | A:301 | (-20.11, 2.18, -22.02) |
| 3:53909975 | rs185517223 | R>Q | A:304 | (-21.50, 6.78, -20.62) |
| 3:53909976 | COSM3408822 COSM3408823 |
R>W | A:304 | (-21.50, 6.78, -20.62) |
| 3:53908383 | L>P | A:307 | (-23.97, 14.18, -11.60) | |
| 3:53908368 | rs556271519 | S>Y | A:312 | (-34.00, 20.92, -7.30) |
| 3:53908348 | rs139980171 | Y>D | A:319 | (-36.19, 28.59, 1.12) |
| 3:53908326 | G>V | A:326 | (-35.88, 37.72, 4.79) | |
| 3:53908321 | rs192918726 | P>S | A:328 | (-41.11, 37.60, 2.84) |
| 3:53908315 | R>G | A:330 | (-42.28, 35.34, 6.98) | |
| 3:53908305 | Q>R | A:333 | (-43.72, 24.22, 4.32) | |
| 3:53908288 | D>Y | A:339 | (-44.52, 26.28, -1.20) | |
| 3:53908281 | L>R | A:341 | (-44.51, 25.03, -7.80) | |
| 3:53908270 | H>N | A:345 | (-41.44, 31.35, -10.48) | |
| 3:53908263 | rs376401536 | K>T | A:347 | (-34.77, 29.02, -9.76) |
| 3:53908258 | T>A | A:349 | (-37.44, 34.99, -11.97) | |
| 3:53908253 | F>L | A:350 | (-35.56, 36.54, -8.95) | |
| 3:53907138 | Q>R | A:361 | (-31.26, 44.64, -6.99) | |
| 3:53907139 | Q>E | A:361 | (-31.26, 44.64, -6.99) | |
| 3:53907126 | F>Y | A:365 | (-42.78, 37.44, -4.63) | |
| 3:53907112 | P>S | A:370 | (-54.86, 27.51, -3.37) | |
| 3:53907105 | S>F | A:372 | (-55.12, 32.24, -0.83) | |
| 3:53907103 | P>S | A:373 | (-54.96, 35.70, -1.08) | |
| 3:53907081 | R>Q | A:380 | (-33.95, 45.27, -0.85) | |
| 3:53907070 | E>Q | A:384 | (-28.60, 35.87, -2.63) | |
| 3:53907067 | K>E | A:385 | (-29.83, 36.93, -7.53) | |
| 3:53907060 | Q>P | A:387 | (-24.54, 32.73, -3.95) | |
| 3:53906551 | rs201796393 | A>S | A:388 | (-27.37, 29.33, -6.21) |
| 3:53906548 | rs371924812 | P>S | A:389 | (-26.80, 29.29, -9.45) |
| 3:53906545 | COSM1244201 COSM1244202 |
M>V | A:390 | (-22.18, 29.32, -8.68) |
| 3:53906536 | F>L | A:393 | (-20.44, 25.14, -11.34) | |
| 3:53906527 | rs371132984 | A>T | A:396 | (-21.05, 21.01, -1.29) |
| 3:53906524 | rs377647744 | T>A | A:397 | (-23.29, 24.21, -1.30) |
| 3:53906496 | rs373126432 | T>M | A:406 | (-20.94, 10.33, -8.80) |
| 3:53905321 | S>L | A:502 | (-16.16, 5.04, -3.88) | |
| 3:53905297 | rs535696904 | G>D | A:510 | (-18.76, 19.63, -10.69) |
| 3:53905291 | D>G | A:512 | (-16.64, 22.42, -14.23) | |
| 3:53905276 | H>R | A:517 | (-13.42, 13.02, -15.73) | |
| 3:53904153 | K>N | A:529 | (-9.06, 18.32, -31.10) | |
| 3:53904154 | K>R | A:529 | (-9.06, 18.32, -31.10) | |
| 3:53904147 | M>I | A:531 | (-15.50, 16.62, -27.48) | |
| 3:53904134 | L>V | A:536 | (-24.72, 20.59, -26.07) | |
| 3:53904106 | rs376058740 | H>R | A:545 | (-28.78, 35.94, -17.99) |
| 3:53904083 | H>Y | A:553 | (-14.52, 32.01, -17.91) | |
| 3:53904080 | R>G | A:554 | (-15.38, 27.87, -14.53) | |
| 3:53904071 | N>H | A:557 | (-9.75, 29.25, -17.21) | |
| 3:53904062 | rs373952185 | P>T | A:560 | (-6.28, 21.15, -20.62) |
| 3:53904051 | F>L | A:563 | (-5.87, 19.79, -25.68) | |
| 3:53904043 | I>T | A:566 | (-4.24, 22.49, -29.95) | |
| 3:53902876 | R>Q | A:582 | (-37.20, 22.88, -21.45) | |
| 3:53902869 | I>M | A:584 | (-33.13, 19.54, -27.88) | |
| 3:53902870 | I>T | A:584 | (-33.13, 19.54, -27.88) | |
| 3:53902868 | A>P | A:585 | (-34.10, 15.33, -27.00) | |
| 3:53902856 | rs200802750 | G>R | A:589 | (-36.50, 11.51, -31.66) |
| 3:53902844 | A>P | A:593 | (-38.00, 8.37, -37.04) | |
| 3:53902804 | COSM3427769 COSM3427770 |
R>Q | A:606 | (-44.91, -12.65, -33.04) |
| 3:53902792 | R>H | A:610 | (-41.65, -15.31, -30.10) | |
| 3:53902784 | V>I | A:613 | (-34.27, -9.23, -23.29) | |
| 3:53902780 | R>H | A:614 | (-32.63, -13.06, -28.41) | |
| 3:53902778 | M>V | A:615 | (-34.75, -8.46, -29.34) | |
| 3:53902765 | R>Q | A:619 | (-33.31, -5.49, -33.23) | |
| 3:53902766 | R>W | A:619 | (-33.31, -5.49, -33.23) | |
| 3:53902759 | A>V | A:621 | (-28.28, 1.19, -31.22) | |
| 3:53902760 | rs532148065 | A>S | A:621 | (-28.28, 1.19, -31.22) |
| 3:53902754 | V>L | A:623 | (-23.84, -1.56, -26.49) |