General Structure Information
| PDB ID | 3odx |
| HGNC Gene Label(s) | ARHGEF1 |
| Structure Name | crystal structure of an n-terminally truncated linker-dh/ph domains of p115-rhogef |
| Resolution | 3.2Å |
| Reference | AUTH Z.CHEN,L.GUO,S.R.SPRANG,P.C.STERNWEISTITL MODULATION OF A GEF SWITCH: AUTOINHIBITION OF THE INTRINSICTITL 2 GUANINE NUCLEOTIDE EXCHANGE ACTIVITY OF P115-RHOREFREF PROTEIN SCI. V. 20 107 2011REFN ISSN 0961-8368 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 336 |
| Number Of SNVs | 55 |
| Number Of Permutations | 38349 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.411 |
| p-value | 0.679 |
COSMIC
| Number Of Residues | 336 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.167 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 55 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | -0.172 |
| p-value | 0.798 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
