Assessment of Structural Intolerance and Durability
General Structure Information 3lb6 IL13RA2 the structure of il-13 in complex with il-13ralpha2 3.05Å AUTH P.J.LUPARDUS,M.E.BIRNBAUM,K.C.GARCIATITL MOLECULAR BASIS FOR SHARED CYTOKINE RECOGNITION REVEALED INTITL 2 THE STRUCTURE OF AN UNUSUALLY HIGH AFFINITY COMPLEX BETWEENTITL 3 IL-13 AND IL-13RALPHA2.REF STRUCTURE V. 18 332 2010REFN ISSN 0969-2126PMID 20223216DOI 10.1016/J.STR.2010.01.003 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3h8m EPHA7 sam domain of human ephrin type-a receptor 7 (epha7) 2.1Å AUTH J.R.WALKER,L.YERMEKBAYEVA,C.BUTLER-COLE,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL SAM DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 7TITL 2 (EPHA7)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4f7b SCARB2 structure of the lysosomal domain of limp-2 3.0Å AUTH D.NECULAI,M.SCHWAKE,M.RAVICHANDRAN,F.ZUNKE,R.F.COLLINS,AUTH 2 J.PETERS,M.NECULAI,J.PLUMB,P.LOPPNAU,J.C.PIZARRO,A.SEITOVA,AUTH 3 W.S.TRIMBLE,P.SAFTIG,S.GRINSTEIN,S.DHE-PAGANONTITL STRUCTURE OF LIMP-2 PROVIDES FUNCTIONAL INSIGHTS WITHTITL 2 IMPLICATIONS FOR SR-BI AND CD36.REF NATURE V. 504 172 2013REFN ISSN 0028-0836PMID 24162852DOI 10.1038/NATURE12684 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3sm9 GRM3 crystal structure of metabotropic glutamate receptor 3 precursor in presence of ly341495 antagonist 2.26Å AUTH A.K.WERNIMONT,A.DONG,A.SEITOVA,L.CROMBET,G.KHUTORESKAYA,AUTH 2 A.M.EDWARDS,C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,D.COSSAR,AUTH 3 E.DOBROVETSKYTITL CRYSTAL STRUCTURE OF METABOTROPIC GLUTAMATE RECEPTOR 3TITL 2 PRECURSOR IN PRESENCE OF LY341495 ANTAGONISTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2rei EPHA7 kinase domain of human ephrin type-a receptor 7 (epha7) 1.6Å AUTH J.R.WALKER,D.CUERRIER,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 7TITL 2 (EPHA7).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bbt ERBB4 crystal structure of the erbb4 kinase in complex with lapatinib 2.8Å AUTH C.QIU,M.K.TARRANT,S.H.CHOI,A.SATHYAMURTHY,R.BOSE,S.BANJADE,AUTH 2 A.PAL,W.G.BORNMANN,M.A.LEMMON,P.A.COLE,D.J.LEAHYTITL MECHANISM OF ACTIVATION AND INHIBITION OF THE HER4/ERBB4TITL 2 KINASE.REF STRUCTURE V. 16 460 2008REFN ISSN 0969-2126PMID 18334220DOI 10.1016/J.STR.2007.12.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ct4 TRIP10 solution strutcure of the sh3 domain of the cdc42- interacting protein 4 -1.0Å AUTH K.MIYAMOTO,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUTCURE OF THE SH3 DOMAIN OF THETITL 2 CDC42-INTERACTING PROTEIN 4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3f7p PLEC crystal structure of a complex between integrin beta4 and plectin 2.75Å AUTH J.M.DE PEREDA,M.P.LILLO,A.SONNENBERGTITL STRUCTURAL BASIS OF THE INTERACTION BETWEENTITL 2 INTEGRIN ALPHA6BETA4 AND PLECTIN AT THETITL 3 HEMIDESMOSOMESREF EMBO J. V. 28 1180 2009REFN ISSN 0261-4189PMID 19242489DOI 10.1038/EMBOJ.2009.48 Variant Set Distributions Mapped Variants
General Structure Information 2z7x TLR1 crystal structure of the tlr1-tlr2 heterodimer induced by binding of a tri-acylated lipopeptide 2.1Å AUTH M.S.JIN,S.E.KIM,J.Y.HEO,M.E.LEE,H.M.KIM,S.G.PAIK,H.LEE,AUTH 2 J.O.LEETITL CRYSTAL STRUCTURE OF THE TLR1-TLR2 HETERODIMER INDUCED BYTITL 2 BINDING OF A TRI-ACYLATED LIPOPEPTIDEREF CELL(CAMBRIDGE,MASS.) V. 130 1071 2007REFN ISSN 0092-8674PMID 17889651DOI 10.1016/J.CELL.2007.09.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1j7v IL10RA human il-10 / il-10r1 complex 2.9Å AUTH K.JOSEPHSON,N.J.LOGSDON,M.R.WALTERTITL CRYSTAL STRUCTURE OF THE IL-10/IL-10R1 COMPLEXTITL 2 REVEALS A SHARED RECEPTOR BINDING SITE.REF IMMUNITY V. 15 35 2001REFN ISSN 1074-7613PMID 11485736DOI 10.1016/S1074-7613(01)00169-8 Variant Set Distributions Mapped Variants