Assessment of Structural Intolerance and Durability
General Structure Information 1de4 HFE hemochromatosis protein hfe complexed with transferrin receptor 2.8Å AUTH M.J.BENNETT,J.A.LEBRON,P.J.BJORKMANTITL CRYSTAL STRUCTURE OF THE HEREDITARY HAEMOCHROMATOSIS PROTEINTITL 2 HFE COMPLEXED WITH TRANSFERRIN RECEPTOR.REF NATURE V. 403 46 2000REFN ISSN 0028-0836PMID 10638746DOI 10.1038/47417 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4bst RSPO1 structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in p6122 crystal form 4.3Å AUTH W.C.PENG,W.DE LAU,F.FORNERIS,J.C.M.GRANNEMAN,M.HUCH,AUTH 2 H.CLEVERS,P.GROSTITL STRUCTURE OF STEM CELL GROWTH FACTOR R-SPONDIN 1 IN COMPLEXTITL 2 WITH THE ECTODOMAIN OF ITS RECEPTOR LGR5.REF CELL REP. V. 3 1885 2013REFN ISSN 2211-1247PMID 23809763DOI 10.1016/J.CELREP.2013.06.009 Variant […]
General Structure Information 3kgr LAIR1 crystal structure of the human leukocyte-associated ig-like receptor-1 (lair-1) 1.8Å AUTH T.H.C.BRONDIJK,T.DE RUITER,J.BALLERING,H.WIENK,R.J.LEBBINK,AUTH 2 H.VAN INGEN,R.BOELENS,R.W.FARNDALE,L.MEYAARD,E.G.HUIZINGATITL CRYSTAL STRUCTURE AND COLLAGEN-BINDING SITE OF IMMUNETITL 2 INHIBITORY RECEPTOR LAIR-1: UNEXPECTED IMPLICATIONS FORTITL 3 COLLAGEN BINDING BY PLATELET RECEPTOR GPVIREF BLOOD V. 115 1364 2010REFN ISSN 0006-4971PMID 20007810DOI 10.1182/BLOOD-2009-10-246322 Variant Set Distributions Ripley’s […]
General Structure Information 1wwc NTRK3 nt3 binding domain of human trkc receptor 1.9Å AUTH M.H.ULTSCH,C.WIESMANN,L.C.SIMMONS,J.HENRICH,M.YANG,D.REILLY,AUTH 2 S.H.BASS,A.M.DE VOSTITL CRYSTAL STRUCTURES OF THE NEUROTROPHIN-BINDING DOMAIN OFTITL 2 TRKA, TRKB AND TRKC.REF J.MOL.BIOL. V. 290 149 1999REFN ISSN 0022-2836PMID 10388563DOI 10.1006/JMBI.1999.2816 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4lp5 AGER crystal structure of the full-length human rage extracellular domain (vc1c2 fragment) 3.8Å AUTH L.YATIME,G.R.ANDERSENTITL STRUCTURAL INSIGHTS INTO THE OLIGOMERIZATION MODE OF THETITL 2 HUMAN RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS.REF FEBS J. V. 280 6556 2013REFN ISSN 1742-464XPMID 24119142DOI 10.1111/FEBS.12556 Variant Set Distributions Mapped Variants
General Structure Information 3g2f BMPR2 crystal structure of the kinase domain of bone morphogenetic protein receptor type ii (bmpr2) at 2.35 a resolution 2.35Å TITL CRYSTAL STRUCTURE OF THE BMPR2 KINASE DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2v7c NR1D2 crystal structure of rev-erb beta 2.4Å AUTH E.-J.WOO,D.G.JEONG,M.-Y.LIM,S.J.KIM,K.-J.KIM,AUTH 2 S.-M.YOON,B.-C.PARK,S.E.RYUTITL STRUCTURAL INSIGHT INTO THE CONSTITUTIVETITL 2 REPRESSION FUNCTION OF THE NUCLEAR RECEPTORTITL 3 REV-ERBBETAREF J.MOL.BIOL. V. 373 735 2007REFN ISSN 0022-2836PMID 17870090DOI 10.1016/J.JMB.2007.08.037 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2qlu ACVR2B crystal structure of activin receptor type ii kinase domain from human 2.0Å AUTH S.HAN,P.LOULAKIS,M.GRIFFOR,Z.XIETITL CRYSTAL STRUCTURE OF ACTIVIN RECEPTOR TYPE IIBTITL 2 KINASE DOMAIN FROM HUMAN AT 2.0 ANGSTROM RESOLUTIONREF PROTEIN SCI. V. 16 2272 2007REFN ISSN 0961-8368PMID 17893364DOI 10.1110/PS.073068407 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4erv RYR3 crystal structure of human ryanodine receptor 3 (2597-2800) 1.75Å AUTH Z.YUCHI,K.LAU,F.VAN PETEGEMTITL DISEASE MUTATIONS IN THE RYANODINE RECEPTOR CENTRAL REGION:TITL 2 CRYSTAL STRUCTURES OF A PHOSPHORYLATION HOT SPOT DOMAIN.REF STRUCTURE V. 20 1201 2012REFN ISSN 0969-2126PMID 22705209DOI 10.1016/J.STR.2012.04.015 Variant Set Distributions Mapped Variants
General Structure Information 2a8b PTPRR crystal structure of the catalytic domain of human tyrosine phosphatase receptor, type r 2.3Å AUTH J.ESWARAN,J.P.VON KRIES,B.MARSDEN,E.LONGMAN,J.E.DEBRECZENI,AUTH 2 E.UGOCHUKWU,A.TURNBULL,W.H.LEE,S.KNAPP,A.J.BARRTITL CRYSTAL STRUCTURES AND INHIBITOR IDENTIFICATION FOR PTPN5,TITL 2 PTPRR AND PTPN7: A FAMILY OF HUMAN MAPK-SPECIFIC PROTEINTITL 3 TYROSINE PHOSPHATASES.REF BIOCHEM.J. V. 395 483 2006REFN ISSN 0264-6021PMID 16441242DOI 10.1042/BJ20051931 Variant Set […]