Assessment of Structural Intolerance and Durability
General Structure Information 2hlq BMPR2 crystal structure of the extracellular domain of the type ii bmp receptor 1.45Å AUTH P.D.MACE,J.F.CUTFIELD,S.M.CUTFIELDTITL HIGH RESOLUTION STRUCTURES OF THE BONETITL 2 MORPHOGENETIC PROTEIN TYPE II RECEPTOR IN TWOTITL 3 CRYSTAL FORMS: IMPLICATIONS FOR LIGAND BINDINGREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 351 831 2006REFN ISSN 0006-291XPMID 17094948DOI 10.1016/J.BBRC.2006.10.109 Variant Set Distributions Mapped Variants
General Structure Information 2c5d GAS6 structure of a minimal gas6-axl complex 3.3Å AUTH T.SASAKI,P.G.KNYAZEV,N.J.CLOUT,Y.CHEBURKIN,AUTH 2 W.GOEHRING,A.ULLRICH,R.TIMPL,E.HOHENESTERTITL STRUCTURAL BASIS FOR GAS6-AXL SIGNALLING.REF EMBO J. V. 25 80 2006REFN ISSN 0261-4189PMID 16362042DOI 10.1038/SJ.EMBOJ.7600912 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1lv2 HNF4G hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids 2.7Å AUTH G.B.WISELY,A.B.MILLER,R.G.DAVIS,A.D.JR THORNQUEST,R.JOHNSON,AUTH 2 T.SPITZER,A.SEFLER,B.SHEARER,J.T.MOORE,T.M.WILLSON,AUTH 3 S.P.WILLIAMSTITL HEPATOCYTE NUCLEAR FACTOR 4 IS A TRANSCRIPTION FACTOR THATTITL 2 CONSTITUTIVELY BINDS FATTY ACIDS.REF STRUCTURE V. 10 1225 2002REFN ISSN 0969-2126PMID 12220494DOI 10.1016/S0969-2126(02)00829-8 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1×61 TRIP6 solution structure of the first lim domain of thyroid receptor interacting protein 6 (trip6) -1.0Å AUTH X.R.QIN,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST LIM DOMAIN OFTITL 2 THYROID RECEPTOR INTERACTING PROTEIN 6 (TRIP6)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1×61 TRIP6 solution structure of the first lim domain of thyroid receptor interacting protein 6 (trip6) -1.0Å AUTH X.R.QIN,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST LIM DOMAIN OFTITL 2 THYROID RECEPTOR INTERACTING PROTEIN 6 (TRIP6)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1×61 TRIP6 solution structure of the first lim domain of thyroid receptor interacting protein 6 (trip6) -1.0Å AUTH X.R.QIN,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST LIM DOMAIN OFTITL 2 THYROID RECEPTOR INTERACTING PROTEIN 6 (TRIP6)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2c7s PTPRK crystal structure of human protein tyrosine phosphatase kappa at 1.95a resolution 1.95Å AUTH J.ESWARAN,J.E.DEBRECZENI,E.LONGMAN,A.BARR,S.KNAPPTITL THE CRYSTAL STRUCTURE OF HUMAN RECEPTOR PROTEIN TYROSINETITL 2 KAPPA PHOSPHATASE KAPPA DOMAIN 1.REF PROTEIN SCI. V. 15 1500 2006REFN ISSN 0961-8368PMID 16672235DOI 10.1110/PS.062128706 Variant Set Distributions Mapped Variants
General Structure Information 1by2 LGALS3BP structure of m2bp scavenger receptor cysteine-rich domain 2.0Å AUTH E.HOHENESTER,T.SASAKI,R.TIMPLTITL CRYSTAL STRUCTURE OF A SCAVENGER RECEPTOR CYSTEINE-RICHTITL 2 DOMAIN SHEDS LIGHT ON AN ANCIENT SUPERFAMILY.REF NAT.STRUCT.BIOL. V. 6 228 1999REFN ISSN 1072-8368PMID 10074941DOI 10.1038/6669 Variant Set Distributions Mapped Variants
General Structure Information 3pls MST1R ron in complex with ligand amp-pnp 2.24Å AUTH J.WANG,S.STEINBACHER,M.AUGUSTIN,P.SCHREINER,D.EPSTEIN,AUTH 2 M.J.MULVIHILL,A.P.CREWTITL THE CRYSTAL STRUCTURE OF A CONSTITUTIVELY ACTIVE MUTANT RONTITL 2 KINASE SUGGESTS AN INTRAMOLECULAR AUTOPHOSPHORYLATIONTITL 3 HYPOTHESISREF BIOCHEMISTRY V. 49 7972 2010REFN ISSN 0006-2960PMID 20726546 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3pls MST1R ron in complex with ligand amp-pnp 2.24Å AUTH J.WANG,S.STEINBACHER,M.AUGUSTIN,P.SCHREINER,D.EPSTEIN,AUTH 2 M.J.MULVIHILL,A.P.CREWTITL THE CRYSTAL STRUCTURE OF A CONSTITUTIVELY ACTIVE MUTANT RONTITL 2 KINASE SUGGESTS AN INTRAMOLECULAR AUTOPHOSPHORYLATIONTITL 3 HYPOTHESISREF BIOCHEMISTRY V. 49 7972 2010REFN ISSN 0006-2960PMID 20726546 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants