Assessment of Structural Intolerance and Durability
General Structure Information 2dmi TSHZ3 solution structure of the first and the second zf-c2h2 like domains of human teashirt homolog 3 -1.0Å AUTH H.ENDO,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST AND THE SECONDTITL 2 ZF-C2H2 LIKE DOMAINS OF HUMAN TEASHIRT HOMOLOG 3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3l4h HECW1 helical box domain and second ww domain of the human e3 ubiquitin- protein ligase hecw1 1.8Å AUTH J.R.WALKER,L.QIU,Y.LI,J.WEIGELT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL THE TANDEM HELICAL BOX AND SECOND WW DOMAINS OF HUMAN HECW1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2xst LCN15 crystal structure of the human lipocalin 15 1.63Å AUTH J.R.C.MUNIZ,C.GILEADI,W.W.YUE,T.KROJER,E.UGOCHUKWU,AUTH 2 C.PHILLIPS,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 3 C.BOUNTRA,K.L.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE HUMAN LIPOCALIN 15REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2kdd CDCA8 solution structure of the conserved c-terminal dimerization domain of borealin -1.0Å AUTH E.BOURHIS,A.LINGEL,Q.PHUNG,W.J.FAIRBROTHER,AUTH 2 A.G.COCHRANTITL PHOSPHORYLATION OF A BOREALIN DIMERIZATION DOMAINTITL 2 IS REQUIRED FOR PROPER CHROMOSOME SEGREGATION.REF BIOCHEMISTRY V. 48 6783 2009REFN ISSN 0006-2960PMID 19530738DOI 10.1021/BI900530V Variant Set Distributions Mapped Variants
General Structure Information 2lz1 NFE2L2 solution nmr structure of the dna-binding domain of human nf-e2- related factor 2, northeast structural genomics consortium (nesg) target hr3520o -1.0Å AUTH A.ELETSKY,S.V.S.R.K.PULAVARTI,D.LEE,E.KOHAN,H.JANJUA,R.XIAO,AUTH 2 T.B.ACTON,J.K.EVERETT,G.T.MONTELIONE,T.SZYPERSKITITL SOLUTION NMR STRUCTURE OF THE DNA-BINDING DOMAIN OF HUMANTITL 2 NF-E2-RELATED FACTOR 2, NORTHEAST STRUCTURAL GENOMICSTITL 3 CONSORTIUM (NESG) TARGET HR3520OREF TO BE PUBLISHEDREFN Variant […]
General Structure Information 3mpx FGD5 crystal structure of the dh and ph-1 domains of human fgd5 2.8Å AUTH Y.SHEN,L.NEDYALKOVA,Y.TONG,W.TEMPEL,L.CROMBET,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE DH AND PH-1 DOMAINS OF HUMAN FGD5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2xt3 KIF7 human kif7, a kinesin involved in hedgehog signalling 1.88Å AUTH M.KLEJNOT,F.KOZIELSKITITL STRUCTURAL INSIGHTS INTO HUMAN KIF7, A KINESIN INVOLVED INTITL 2 HEDGEHOG SIGNALLING.REF ACTA CRYSTALLOGR.,SECT.D V. 68 154 2012REFN ISSN 0907-4449PMID 22281744DOI 10.1107/S0907444911053042 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2yuh TBCC solution structure of the c-terminal region in human tubulin folding cofactor c -1.0Å AUTH K.SAITO,N.TOCHIO,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C-TERMINAL REGION INTITL 2 HUMAN TUBULIN FOLDING COFACTOR CREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3b6y IFI16 crystal structure of the second hin-200 domain of interferon-inducible protein 16 2.35Å AUTH J.C.C.LIAO,R.LAM,M.RAVICHANDRAN,S.DUAN,W.TEMPEL,AUTH 2 N.Y.CHIRGADZE,C.H.ARROWSMITHTITL CRYSTAL STRUCTURE ANALYSIS OF THE SECOND HIN DOMAIN OFTITL 2 IFI16.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3aqf CALCRL crystal structure of the human crlr/ramp2 extracellular complex 2.6Å AUTH S.KUSANO,M.KUKIMOTO-NIINO,N.HINO,N.OHSAWA,K.OKUDA,AUTH 2 K.SAKAMOTO,M.SHIROUZU,T.SHINDO,S.YOKOYAMATITL STRUCTURAL BASIS FOR EXTRACELLULAR INTERACTIONS BETWEENTITL 2 CALCITONIN RECEPTOR-LIKE RECEPTOR AND RECEPTORTITL 3 ACTIVITY-MODIFYING PROTEIN 2 FOR ADRENOMEDULLIN-SPECIFICTITL 4 BINDINGREF PROTEIN SCI. V. 21 199 2012REFN ISSN 0961-8368PMID 22102369DOI 10.1002/PRO.2003 Variant Set Distributions Mapped Variants