Assessment of Structural Intolerance and Durability
General Structure Information 2hw6 MKNK1 crystal structure of mnk1 catalytic domain 2.5Å AUTH R.JAUCH,M.K.CHO,C.NETTER,K.SCHREITER,B.AICHER,AUTH 2 M.ZWECKSTETTER,M.C.WAHLTITL MITOGEN-ACTIVATED PROTEIN KINASES INTERACTING KINASES ARETITL 2 AUTOINHIBITED BY A REPROGRAMMED ACTIVATION SEGMENT.REF EMBO J. V. 25 4020 2006REFN ISSN 0261-4189PMID 16917500DOI 10.1038/SJ.EMBOJ.7601285 Variant Set Distributions Mapped Variants
General Structure Information 2p0f ARHGAP9 arhgap9 ph domain in complex with ins(1,3,5)p3 1.91Å AUTH D.F.CECCARELLI,I.M.BLASUTIG,M.GOUDREAULT,Z.LI,AUTH 2 J.RUSTON,T.PAWSON,F.SICHERITITL NON-CANONICAL INTERACTION OF PHOSPHOINOSITIDESTITL 2 WITH PLECKSTRIN HOMOLOGY DOMAINS OF TIAM1 ANDTITL 3 ARHGAP9.REF J.BIOL.CHEM. V. 282 13864 2007REFN ISSN 0021-9258PMID 17339315DOI 10.1074/JBC.M700505200 Variant Set Distributions Mapped Variants
General Structure Information 3f6k SORT1 crystal structure of the vps10p domain of human sortilin/nts3 in complex with neurotensin 2.0Å AUTH E.M.QUISTGAARD,P.MADSEN,M.K.GROFTEHAUGE,P.NISSEN,AUTH 2 C.M.PETERSEN,S.S.THIRUPTITL LIGANDS BIND TO SORTILIN IN THE TUNNEL OF A TEN-BLADEDTITL 2 BETA-PROPELLER DOMAIN.REF NAT.STRUCT.MOL.BIOL. V. 16 96 2009REFN ISSN 1545-9993PMID 19122660DOI 10.1038/NSMB.1543 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2kv3 REG4 human regenerating gene type iv (reg iv) protein, p91s mutant -1.0Å AUTH M.HO,Y.LOU,S.WEI,S.LUO,W.LIN,P.LYU,C.CHENTITL HUMAN REGIV PROTEIN ADOPTS A TYPICAL C-TYPE LECTIN FOLD BUTTITL 2 BINDS MANNAN WITH TWO CALCIUM-INDEPENDENT SITESREF J.MOL.BIOL. 2010REFN ESSN 1089-8638DOI 10.1016/J.JMB.2010.07.061 Variant Set Distributions Mapped Variants
General Structure Information 3n1g BOC crystal structure of dhhn bound to bocfn3 1.9Å AUTH J.M.KAVRAN,M.D.WARD,O.O.OLADOSU,S.MULEPATI,D.J.LEAHYTITL ALL MAMMALIAN HEDGEHOG PROTEINS INTERACT WITH CDO AND BOCTITL 2 IN A CONSERVED MANNER.REF J.BIOL.CHEM. 2010REFN ESSN 1083-351XPMID 20519495DOI 10.1074/JBC.M110.131680 Variant Set Distributions Mapped Variants
General Structure Information 2jrf TPPP3 solution nmr structure of tubulin polymerization-promoting protein family member 3 from homo sapiens. northeast structural genomics target hr387. -1.0Å AUTH J.M.ARAMINI,P.ROSSI,R.SHASTRY,C.NWOSU,K.CUNNINGHAM,AUTH 2 R.XIAO,J.LIU,M.C.BARAN,P.K.RAJAN,T.B.ACTON,B.ROST,AUTH 3 G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF TUBULINTITL 2 POLYMERIZATION-PROMOTING PROTEIN FAMILY MEMBER 3TITL 3 FROM HOMO SAPIENS.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4nsc MICU1 crystal structure of cbara1 in the apo-form 3.2Å AUTH L.WANG,X.YANG,S.LI,Z.WANG,Y.LIU,J.FENG,Y.ZHU,Y.SHENTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO MICU1 REGULATION OFTITL 2 MITOCHONDRIAL CALCIUM UPTAKE.REF EMBO J. V. 33 594 2014REFN ISSN 0261-4189PMID 24514027DOI 10.1002/EMBJ.201386523 Variant Set Distributions Mapped Variants
General Structure Information 3nw0 NDNL2 crystal structure of mageg1 and nse1 complex 2.92Å AUTH J.M.DOYLE,J.GAO,J.WANG,M.YANG,P.R.POTTSTITL MAGE-RING PROTEIN COMPLEXES COMPRISE A FAMILY OF E3TITL 2 UBIQUITIN LIGASES.REF MOL.CELL V. 39 963 2010REFN ISSN 1097-2765PMID 20864041DOI 10.1016/J.MOLCEL.2010.08.029 Variant Set Distributions Mapped Variants
General Structure Information 2le9 S100A13 ragec2-s100a13 tetrameric complex -1.0Å AUTH S.G.RANI,S.K.MOHAN,C.YUTITL INTERACTION OF S100A13 WITH RECEPTOR FOR ADVANCED GLYCATIONTITL 2 END PRODUCTS (RAGE) C2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3c5r BARD1 crystal structure of the bard1 ankyrin repeat domain and its functional consequences 2.0Å AUTH D.FOX,I.LE TRONG,P.RAJAGOPAL,P.S.BRZOVIC,R.E.STENKAMP,AUTH 2 R.E.KLEVITTITL CRYSTAL STRUCTURE OF THE BARD1 ANKYRIN REPEAT DOMAIN AND ITSTITL 2 FUNCTIONAL CONSEQUENCES.REF J.BIOL.CHEM. V. 283 21179 2008REFN ISSN 0021-9258PMID 18480049DOI 10.1074/JBC.M802333200 Variant Set Distributions Mapped Variants