Assessment of Structural Intolerance and Durability
General Structure Information 2yqm RUFY1 solution structure of the fyve domain in zinc finger fyve domain-containing protein 12 -1.0Å AUTH F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FYVE DOMAIN IN ZINCTITL 2 FINGER FYVE DOMAIN-CONTAINING PROTEIN 12REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2bo9 LXN human carboxypeptidase a4 in complex with human latexin. 1.6Å AUTH I.PALLARES,R.BONET,R.GARCIA-CASTELLANOS,S.VENTURA,AUTH 2 F.X.AVILES,J.VENDRELL,F.X.GOMIS-RUETHTITL STRUCTURE OF HUMAN CARBOXYPEPTIDASE A4 WITH ITSTITL 2 ENDOGENOUS PROTEIN INHIBITOR, LATEXIN.REF PROC.NATL.ACAD.SCI.USA V. 102 3978 2005REFN ISSN 0027-8424PMID 15738388DOI 10.1073/PNAS.0500678102 Variant Set Distributions Mapped Variants
General Structure Information 2kdb HERPUD2 solution structure of human ubiquitin-like domain of herpud2_9_85, northeast structural genomics consortium (nesg) target ht53a -1.0Å AUTH R.DOHERTY,B.WU,C.FARES,A.LEMAK,A.GUTMANAS,A.SEMESI,A.YEE,AUTH 2 C.H.ARROWSMITH,S.DHE-PAGANONTITL STRUCTURE OF HUMAN HOMOCYSTEINE-INDUCIBLE, ENDOPLASMICTITL 2 RETICULUM STRESS-INDUCIBLE, UBIQUITIN-LIKE DOMAIN MEMBER 2TITL 3 (HERPUD2 OR HERP)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2jam CAMK1G crystal structure of human calmodulin-dependent protein kinase i g 1.7Å AUTH J.E.DEBRECZENI,A.BULLOCK,T.KEATES,F.H.NIESEN,AUTH 2 E.SALAH,L.SHRESTHA,C.SMEE,F.SOBOTT,A.C.W.PIKE,AUTH 3 G.BUNKOCZI,F.VON DELFT,A.TURNBULL,J.WEIGELT,AUTH 4 C.H.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENTTITL 2 PROTEIN KINASE I GREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3fzm BAG1 crystal structures of hsc70/bag1 in complex with small molecule inhibitors 2.3Å AUTH D.S.WILLIAMSON,J.BORGOGNONI,A.CLAY,Z.DANIELS,AUTH 2 P.DOKURNO,M.J.DRYSDALE,N.FOLOPPE,G.L.FRANCIS,AUTH 3 C.J.GRAHAM,R.HOWES,A.T.MACIAS,J.B.MURRAY,R.PARSONS,AUTH 4 T.SHAW,A.E.SURGENOR,L.TERRY,Y.WANG,M.WOOD,AUTH 5 A.J.MASSEYTITL NOVEL ADENOSINE-DERIVED INHIBITORS OF 70 KDA HEATTITL 2 SHOCK PROTEIN, DISCOVERED THROUGH STRUCTURE-BASEDTITL 3 DESIGNREF J.MED.CHEM. V. 52 1510 2009REFN ISSN 0022-2623PMID 19256508DOI 10.1021/JM801627A Variant Set Distributions Ripley’s K […]
General Structure Information 2zv2 CAMKK2 crystal structure of human calcium/calmodulin-dependent protein kinase kinase 2, beta, camkk2 kinase domain in complex with sto-609 2.4Å AUTH M.KUKIMOTO-NIINO,S.YOSHIKAWA,T.TAKAGI,N.OHSAWA,Y.TOMABECHI,AUTH 2 T.TERADA,M.SHIROUZU,A.SUZUKI,S.LEE,T.YAMAUCHI,M.OKADA-IWABU,AUTH 3 M.IWABU,T.KADOWAKI,Y.MINOKOSHI,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE CA2+/CALMODULIN-DEPENDENT PROTEINTITL 2 KINASE KINASE IN COMPLEX WITH THE INHIBITOR STO-609REF J.BIOL.CHEM. V. 286 22570 2011REFN ISSN 0021-9258PMID 21504895DOI 10.1074/JBC.M111.251710 Variant Set […]
General Structure Information 2d9x OSBPL11 solution structure of the ph domain of oxysterol binding protein-related protein 11 from human -1.0Å AUTH H.LI,M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF OXYSTEROLTITL 2 BINDING PROTEIN-RELATED PROTEIN 11 FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4bhx PEG3 crystal structure of the scan domain from human paternally expressed gene 3 protein 1.95Å AUTH V.RIMSA,T.C.EADSFORTH,W.N.HUNTERTITL STRUCTURE OF THE SCAN DOMAIN OF HUMAN PATERNALLY EXPRESSEDTITL 2 GENE 3 PROTEIN.REF PLOS ONE V. 8E69538 2013REFN ISSN 1932-6203PMID 23936039DOI 10.1371/JOURNAL.PONE.0069538 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1wbp SRPK1 srpk1 bound to 9mer docking motif peptide 2.4Å AUTH J.C.NGO,S.CHAKRABARTI,J.-H.DING,A.VELAZQUEZ-DONES,AUTH 2 B.NOLEN,B.E.AUBOL,J.A.ADAMS,X.-D.FU,G.GHOSHTITL INTERPLAY BETWEEN SRPK AND CLK/STY KINASES INTITL 2 PHOSPHORYLATION OF THE SPLICING FACTOR ASF/SF2 ISTITL 3 REGULATED BY A DOCKING MOTIF IN ASF/SF2REF MOL.CELL V. 20 77 2005REFN ISSN 1097-2765PMID 16209947DOI 10.1016/J.MOLCEL.2005.08.025 Variant Set Distributions Mapped Variants
General Structure Information 2lql CHCHD5 solution structure of chch5 -1.0Å AUTH L.BANCI,I.BERTINI,S.CIOFI-BAFFONI,D.JAISWAL,S.NERI,AUTH 2 R.PERUZZINI,J.WINKELMANNTITL STRUCTURAL CHARACTERIZATION OF CHCHD5 AND CHCHD7: TWOTITL 2 ATYPICAL HUMAN TWIN CX(9)C PROTEINS.REF J.STRUCT.BIOL. V. 180 190 2012REFN ISSN 1047-8477PMID 22842048DOI 10.1016/J.JSB.2012.07.007 Variant Set Distributions Mapped Variants