Assessment of Structural Intolerance and Durability
General Structure Information 4giw RUSC1 crystal structure of the run domain of human nesca 2.0Å AUTH Q.SUN,C.HAN,L.LIU,Y.WANG,H.DENG,L.BAI,T.JIANGTITL CRYSTAL STRUCTURE AND FUNCTIONAL IMPLICATION OF THE RUNTITL 2 DOMAIN OF HUMAN NESCAREF PROTEIN CELL V. 3 609 2012REFN ISSN 1674-800XPMID 22821014DOI 10.1007/S13238-012-2052-3 Variant Set Distributions Mapped Variants
General Structure Information 3dls PASK crystal structure of human pas kinase bound to adp 2.3Å AUTH C.K.KIKANI,S.A.ANTONYSAMY,J.B.BONANNO,R.ROMERO,F.F.ZHANG,AUTH 2 M.RUSSELL,T.GHEYI,M.IIZUKA,S.EMTAGE,J.M.SAUDER,B.E.TURK,AUTH 3 S.K.BURLEY,J.RUTTERTITL STRUCTURAL BASES OF PAS DOMAIN-REGULATED KINASE (PASK)TITL 2 ACTIVATION IN THE ABSENCE OF ACTIVATION LOOPTITL 3 PHOSPHORYLATION.REF J.BIOL.CHEM. V. 285 41034 2010REFN ISSN 0021-9258PMID 20943661DOI 10.1074/JBC.M110.157594 Variant Set Distributions Mapped Variants
General Structure Information 2cqd RBM38 solution structure of the rna recognition motif in rna- binding region containing protein 1 -1.0Å AUTH T.SOMEYA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RNA RECOGNITION MOTIF INTITL 2 RNA-BINDING REGION CONTAINING PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2wft HHIP crystal structure of the human hip ectodomain 2.8Å AUTH B.BISHOP,A.R.ARICESCU,K.HARLOS,C.A.OCALLAGHAN,AUTH 2 E.Y.JONES,C.SIEBOLDTITL STRUCTURAL INSIGHTS INTO HEDGEHOG LIGANDTITL 2 SEQUESTRATION BY THE HUMAN HEDGEHOG-INTERACTINGTITL 3 PROTEIN HIPREF NAT.STRUCT.MOL.BIOL. V. 16 698 2009REFN ISSN 1545-9993PMID 19561611DOI 10.1038/NSMB.1607 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4b6d RACGAP1 structure of the atypical c1 domain of mgcracgap 2.2Å AUTH S.LEKOMTSEV,K.SU,V.E.PYE,K.BLIGHT,S.SUNDARAMOORTHY,T.TAKAKI,AUTH 2 L.M.COLLINSON,P.CHEREPANOV,N.DIVECHA,M.PETRONCZKITITL CENTRALSPINDLIN LINKS THE MITOTIC SPINDLE TO THE PLASMATITL 2 MEMBRANE DURING CYTOKINESIS.REF NATURE V. 492 276 2012REFN ISSN 0028-0836PMID 23235882DOI 10.1038/NATURE11773 Variant Set Distributions Mapped Variants
General Structure Information 2cop ACBD6 solution structure of rsgi ruh-040, an acbp domain from human cdna -1.0Å AUTH A.Z.M.RUHUL MOMEN,H.HIROTA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF RSGI RUH-040, AN ACBP DOMAINTITL 2 FROM HUMAN CDNAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1ozn RTN4R 1.5a crystal structure of the nogo receptor ligand binding domain reveals a convergent recognition scaffold mediating inhibition of myelination 1.52Å AUTH X.L.HE,J.F.BAZAN,G.MCDERMOTT,J.B.PARK,K.WANG,AUTH 2 M.TESSIER-LAVIGNE,Z.HE,K.C.GARCIATITL STRUCTURE OF THE NOGO RECEPTOR ECTODOMAIN. A RECOGNITIONTITL 2 MODULE IMPLICATED IN MYELIN INHIBITION.REF NEURON V. 38 177 2003REFN ISSN 0896-6273PMID 12718853DOI 10.1016/S0896-6273(03)00232-0 Variant Set Distributions […]
General Structure Information 2yrg TRIM5 solution structure of the b-box domain from tripartite motif-containing protein 5 -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE B-BOX DOMAIN FROMTITL 2 TRIPARTITE MOTIF-CONTAINING PROTEIN 5REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1jh4 PAIP1 solution structure of the c-terminal pabc domain of human poly(a)-binding protein in complex with the peptide from paip1 -1.0Å AUTH G.KOZLOV,G.DE CRESCENZO,N.S.LIM,N.SIDDIQUI,AUTH 2 D.FANTUS,A.KAHVEJIAN,J.F.TREMPE,D.ELIAS,I.EKIEL,AUTH 3 N.SONENBERG,M.OCONNOR-MCCOURT,K.GEHRINGTITL STRUCTURAL BASIS OF LIGAND RECOGNITION BY PABC, ATITL 2 HIGHLY SPECIFIC PEPTIDE-BINDING DOMAIN FOUND INTITL 3 POLY(A)-BINDING PROTEIN AND A HECT UBIQUITIN LIGASEREF EMBO […]
General Structure Information 3jw0 NEDD4L e2~ubiquitin-hect 3.1Å AUTH H.B.KAMADURAI,J.SOUPHRON,D.C.SCOTT,D.M.DUDA,D.J.MILLER,AUTH 2 D.STRINGER,R.C.PIPER,B.A.SCHULMANTITL INSIGHTS INTO UBIQUITIN TRANSFER CASCADES FROM A STRUCTURETITL 2 OF A UBCH5B APPROXIMATELY UBIQUITIN-HECT(NEDD4L) COMPLEX.REF MOL.CELL V. 36 1095 2009REFN ISSN 1097-2765PMID 20064473DOI 10.1016/J.MOLCEL.2009.11.010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants