Assessment of Structural Intolerance and Durability
General Structure Information 2dao ETV6 solution structure of ets domain transcriptional factor etv6 protein -1.0Å AUTH T.N.NIRAULA,A.SASAGAWA,T.TOMIZAWA,S.KOSHIBA,AUTH 2 M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF ETS DOMAIN TRANSCRIPTIONALTITL 2 FACTOR ETV6 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1n83 RORA crystal structure of the complex between the orphan nuclear hormone receptor ror(alpha)-lbd and cholesterol 1.63Å AUTH J.A.KALLEN,J.M.SCHLAEPPI,F.BITSCH,S.GEISSE,AUTH 2 M.GEISER,I.DELHON,B.FOURNIERTITL X-RAY STRUCTURE OF HROR(ALPHA) LBD AT 1.63A:TITL 2 STRUCTURAL AND FUNCTIONAL DATA THAT CHOLESTEROL ORTITL 3 A CHOLESTEROL DERIVATIVE IS THE NATURAL LIGAND OFTITL 4 ROR(ALPHA)REF STRUCTURE V. 10 1697 2002REFN […]
General Structure Information 1yvl STAT1 structure of unphosphorylated stat1 3.0Å AUTH X.MAO,Z.REN,G.N.PARKER,H.SONDERMANN,M.A.PASTORELLO,AUTH 2 W.WANG,J.S.MCMURRAY,B.DEMELER,J.E.DARNELL,X.CHENTITL STRUCTURAL BASES OF UNPHOSPHORYLATED STAT1TITL 2 ASSOCIATION AND RECEPTOR BINDING.REF MOL.CELL V. 17 761 2005REFN ISSN 1097-2765PMID 15780933DOI 10.1016/J.MOLCEL.2005.02.021 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1v89 ARHGAP25 solution structure of the pleckstrin homology domain of human kiaa0053 protein -1.0Å AUTH H.LI,N.TOCHIO,S.KOSHIBA,M.INOUE,H.HIROTA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PLECKSTRIN HOMOLOGYTITL 2 DOMAIN OF HUMAN KIAA0053 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1mq0 CDA crystal structure of human cytidine deaminase 2.4Å AUTH S.J.CHUNG,J.C.FROMME,G.L.VERDINETITL STRUCTURE OF HUMAN CYTIDINE DEAMINASE BOUND TO A POTENTTITL 2 INHIBITORREF J.MED.CHEM. V. 48 658 2005REFN ISSN 0022-2623PMID 15689149DOI 10.1021/JM0496279 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3be2 KDR crystal structure of the vegfr2 kinase domain in complex with a benzamide inhibitor 1.75Å AUTH J.C.HARMANGE,M.M.WEISS,J.GERMAIN,A.J.POLVERINO,AUTH 2 G.BORG,J.BREADY,D.CHEN,D.CHOQUETTE,A.COXON,AUTH 3 T.DEMELFI,L.DIPIETRO,N.DOERR,J.ESTRADA,J.FLYNN,AUTH 4 R.F.GRACEFFA,S.P.HARRIMAN,S.KAUFMAN,D.S.LA,A.LONG,AUTH 5 M.W.MARTIN,S.NEERVANNAN,V.F.PATEL,M.POTASHMAN,AUTH 6 K.REGAL,P.M.ROVETO,M.L.SCHRAG,C.STARNES,A.TASKER,AUTH 7 Y.TEFFERA,L.WANG,R.D.WHITE,D.A.WHITTINGTON,R.ZANONTITL NAPHTHAMIDES AS NOVEL AND POTENT VASCULARTITL 2 ENDOTHELIAL GROWTH FACTOR RECEPTOR TYROSINE KINASETITL 3 INHIBITORS: DESIGN, SYNTHESIS, AND EVALUATION.REF J.MED.CHEM. V. 51 […]
General Structure Information 2lrr IGHMBP2 solution structure of the r3h domain from human smubp-2 in complex with 2-deoxyguanosine-5-monophosphate -1.0Å AUTH K.JAUDZEMS,X.JIA,H.YAGI,D.ZHULENKOVS,B.GRAHAM,G.OTTING,AUTH 2 E.LIEPINSHTITL STRUCTURAL BASIS FOR 5-END-SPECIFIC RECOGNITION OFTITL 2 SINGLE-STRANDED DNA BY THE R3H DOMAIN FROM HUMAN SMUBP-2REF J.MOL.BIOL. V. 12 760 2012REFN ISSN 0022-2836PMID 22999958DOI 10.1016/J.JMB.2012.09.010 Variant Set Distributions Mapped Variants
General Structure Information 2edd DCC solution structure of the fifth fibronectin type iii domain of human netrin receptor dcc -1.0Å AUTH N.TOCHIO,S.KOSHIBA,T.TOMIZAWA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIFTH FIBRONECTIN TYPETITL 2 III DOMAIN OF HUMAN NETRIN RECEPTOR DCCREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3d42 PTPN7 crystal structure of heptp in complex with a monophosphorylated erk2 peptide 2.46Å AUTH D.A.CRITTON,A.TORTAJADA,G.STETSON,W.PETI,R.PAGETITL STRUCTURAL BASIS OF SUBSTRATE RECOGNITION BY HEMATOPOIETICTITL 2 TYROSINE PHOSPHATASE.REF BIOCHEMISTRY V. 47 13336 2008REFN ISSN 0006-2960PMID 19053285DOI 10.1021/BI801724N Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1am9 SREBF1 human srebp-1a bound to ldl receptor promoter 2.3Å AUTH A.PARRAGA,L.BELLSOLELL,A.R.FERRE-DAMARE,S.K.BURLEYTITL CO-CRYSTAL STRUCTURE OF STEROL REGULATORY ELEMENTTITL 2 BINDING PROTEIN 1A AT 2.3 A RESOLUTION.REF STRUCTURE V. 6 661 1998REFN ISSN 0969-2126PMID 9634703DOI 10.1016/S0969-2126(98)00067-7 Variant Set Distributions Mapped Variants