Assessment of Structural Intolerance and Durability
General Structure Information 2enj PRKCQ solution sturcture of the c2 domain from human protein kinase c theta -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STURCTURE OF THE C2 DOMAIN FROM HUMANTITL 2 PROTEIN KINASE C THETAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1u3b APBA1 auto-inhibition mechanism of x11s/mints family scaffold proteins revealed by the closed conformation of the tandem pdz domains -1.0Å AUTH J.-F.LONG,W.FENG,R.WANG,L.-N.CHAN,F.C.IP,J.XIA,AUTH 2 N.Y.IP,M.ZHANGTITL AUTOINHIBITION OF X11/MINT SCAFFOLD PROTEINSTITL 2 REVEALED BY THE CLOSED CONFORMATION OF THE PDZTITL 3 TANDEMREF NAT.STRUCT.MOL.BIOL. V. 12 722 2005REFN ISSN 1545-9993PMID 16007100DOI 10.1038/NSMB958 Variant Set Distributions […]
General Structure Information 3ks9 GRM1 metabotropic glutamate receptor mglur1 complexed with ly341495 antagonist 1.9Å AUTH E.DOBROVETSKY,G.KHUTORESKAYA,A.SEITOVA,D.COSSAR,A.M.EDWARDS,AUTH 2 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,A.BOCHKAREVTITL METABOTROPIC GLUTAMATE RECEPTOR MGLUR1 COMPLEXED WITHTITL 2 LY341495 ANTAGONISTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4n6j STRN3 crystal structure of human striatin-3 coiled coil domain 2.0Å AUTH C.C.CHEN,Z.B.SHI,W.Q.ZHANG,M.CHEN,F.HE,Z.Z.ZHANG,Y.C.WANG,AUTH 2 M.FENG,W.J.WANG,Y.ZHAO,J.H.BROWN,S.JIAO,Z.C.ZHOUTITL STRIATINS CONTAIN A NONCANONICAL COILED COIL THAT BINDS PP2ATITL 2 A TO FORM A 2:2 HETEROTETRAMERIC CORE OFTITL 3 STRIATIN-INTERACTING PHOSPHATASE AND KINASE (STRIPAK)TITL 4 COMPLEXREF J.BIOL.CHEM. 2014REFN ESSN 1083-351XDOI 10.1074/JBC.M113.529297 Variant Set Distributions Mapped Variants
General Structure Information 1cf4 TNK2 cdc42/ack gtpase-binding domain complex -1.0Å AUTH H.R.MOTT,D.OWEN,D.NIETLISPACH,P.N.LOWE,E.MANSER,AUTH 2 L.LIM,E.D.LAUETITL STRUCTURE OF THE SMALL G PROTEIN CDC42 BOUND TOTITL 2 THE GTPASE-BINDING DOMAIN OF ACK.REF NATURE V. 399 384 1999REFN ISSN 0028-0836PMID 10360579DOI 10.1038/20732 Variant Set Distributions Mapped Variants
General Structure Information 3h3g PTH1R crystal structure of the extracellular domain of the human parathyroid hormone receptor (pth1r) in complex with parathyroid hormone-related protein (pthrp) 1.94Å AUTH A.A.PIOSZAK,N.R.PARKER,T.J.GARDELLA,H.E.XUTITL STRUCTURAL BASIS FOR PARATHYROID HORMONE-RELATED PROTEINTITL 2 BINDING TO THE PARATHYROID HORMONE RECEPTOR AND DESIGN OFTITL 3 CONFORMATION-SELECTIVE PEPTIDES.REF J.BIOL.CHEM. V. 284 28382 2009REFN ISSN 0021-9258PMID 19674967DOI […]
General Structure Information 1kzz TRAF3 downstream regulator tank binds to the cd40 recognition site on traf3 3.5Å AUTH C.LI,C.Z.NI,M.L.HAVERT,E.CABEZAS,J.HE,D.KAISER,AUTH 2 J.C.REED,A.C.SATTERTHWAIT,G.CHENG,K.R.ELYTITL DOWNSTREAM REGULATOR TANK BINDS TO THE CD40TITL 2 RECOGNITION SITE ON TRAF3.REF STRUCTURE V. 10 403 2002REFN ISSN 0969-2126PMID 12005438DOI 10.1016/S0969-2126(02)00733-5 Variant Set Distributions Mapped Variants
General Structure Information 2leb SRSF2 solution structure of human srsf2 (sc35) rrm in complex with 5- uccagu-3 -1.0Å AUTH G.M.DAUBNER,A.CLERY,S.JAYNE,J.STEVENIN,F.H.ALLAINTITL A SYN-ANTI CONFORMATIONAL DIFFERENCE ALLOWS SRSF2 TOTITL 2 RECOGNIZE GUANINES AND CYTOSINES EQUALLY WELL.REF EMBO J. V. 31 162 2012REFN ISSN 0261-4189PMID 22002536DOI 10.1038/EMBOJ.2011.367 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2y4t DNAJC3 crystal structure of the human co-chaperone p58(ipk) 3.0Å AUTH M.SVARD,E.I.BITEROVA,J.-M.BOURHIS,J.E.GUYTITL THE CRYSTAL STRUCTURE OF THE HUMAN CO-CHAPERONE P58IPKREF PLOS ONE V. 6 22337 2011REFN ISSN 1932-6203PMID 21799829DOI 10.1371/JOURNAL.PONE.0022337 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3f8u TAPBP tapasin/erp57 heterodimer 2.6Å AUTH G.DONG,P.A.WEARSCH,D.R.PEAPER,P.CRESSWELL,K.M.REINISCHTITL INSIGHTS INTO MHC CLASS I PEPTIDE LOADING FROM THE STRUCTURETITL 2 OF THE TAPASIN-ERP57 THIOL OXIDOREDUCTASE HETERODIMER.REF IMMUNITY V. 30 21 2009REFN ISSN 1074-7613PMID 19119025DOI 10.1016/J.IMMUNI.2008.10.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants