General Structure Information
| PDB ID | 3ks9 |
| HGNC Gene Label(s) | GRM1 |
| Structure Name | metabotropic glutamate receptor mglur1 complexed with ly341495 antagonist |
| Resolution | 1.9Å |
| Reference | AUTH E.DOBROVETSKY,G.KHUTORESKAYA,A.SEITOVA,D.COSSAR,A.M.EDWARDS,AUTH 2 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,A.BOCHKAREVTITL METABOTROPIC GLUTAMATE RECEPTOR MGLUR1 COMPLEXED WITHTITL 2 LY341495 ANTAGONISTREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 445 |
| Number Of SNVs | 67 |
| Number Of Permutations | 14063 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.041 |
| p-value | 0.023 |
COSMIC
| Number Of Residues | 445 |
| Number Of SNVs | 11 |
| Number Of Permutations | 4037 |
| Optimal Distance Threshold | 31.0 |
| K Statistic | 0.364 |
| p-value | 0.367 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 67 |
| Number Of COSMIC SNVs | 10 |
| Optimal Distance Threshold | 35.0 |
| K Statistic | -0.125 |
| p-value | 0.315 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
