Assessment of Structural Intolerance and Durability
General Structure Information 3qc8 FAF1 crystal structure of faf1 ubx domain in complex with p97/vcp n domain reveals the conserved fcisp touch-turn motif of ubx domain suffering conformational change 2.2Å AUTH K.H.KIM,W.KANG,S.W.SUH,J.K.YANGTITL CRYSTAL STRUCTURE OF FAF1 UBX DOMAIN IN COMPLEX WITH P97/VCPTITL 2 N DOMAIN REVEALS A CONFORMATIONAL CHANGE IN THE CONSERVEDTITL 3 FCISP TOUCH-TURN […]
General Structure Information 1sgo GSKIP nmr structure of the human c14orf129 gene product, hspc210. northeast structural genomics target hr969. -1.0Å AUTH T.A.RAMELOT,J.R.CORT,R.XIAO,L.-Y.SHIH,L.-C.MA,AUTH 2 T.B.ACTON,G.T.MONTELIONE,M.A.KENNEDYTITL NMR STRUCTURE OF THE HUMAN C14ORF129 GENE PRODUCT,TITL 2 HSPC210. NORTHEAST STRUCTURAL GENOMICS TARGETTITL 3 HR969.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1rz4 EIF3K crystal structure of human eif3k 2.1Å AUTH Z.WEI,P.ZHANG,Z.ZHOU,Z.CHENG,M.WAN,W.GONGTITL CRYSTAL STRUCTURE OF HUMAN EIF3K, THE FIRST STRUCTURE OFTITL 2 EIF3 SUBUNITSREF J.BIOL.CHEM. V. 279 34983 2004REFN ISSN 0021-9258PMID 15180986DOI 10.1074/JBC.M405158200 Variant Set Distributions Mapped Variants
General Structure Information 4dxt SUN2 human sun2 (aa 522-717) 2.22Å AUTH B.A.SOSA,A.ROTHBALLER,U.KUTAY,T.U.SCHWARTZTITL LINC COMPLEXES FORM BY BINDING OF THREE KASH PEPTIDES TOTITL 2 DOMAIN INTERFACES OF TRIMERIC SUN PROTEINS.REF CELL(CAMBRIDGE,MASS.) V. 149 1035 2012REFN ISSN 0092-8674PMID 22632968DOI 10.1016/J.CELL.2012.03.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1z0i RAB21 gdp-bound rab21 gtpase 2.33Å AUTH S.EATHIRAJ,X.PAN,C.RITACCO,D.G.LAMBRIGHTTITL STRUCTURAL BASIS OF FAMILY-WIDE RAB GTPASETITL 2 RECOGNITION BY RABENOSYN-5.REF NATURE V. 436 415 2005REFN ISSN 0028-0836PMID 16034420DOI 10.1038/NATURE03798 Variant Set Distributions Mapped Variants
General Structure Information 4lg8 PRPF19 crystal structure of prpf19 wd40 repeats 1.89Å AUTH C.XU,W.TEMPEL,H.HE,E.DOBROVETSKY,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,J.MIN,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF PRPF19 WD40 REPEATSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3rip TUBGCP4 crystal structure of human gamma-tubulin complex protein 4 (gcp4) 2.3Å AUTH V.GUILLET,M.KNIBIEHLER,L.GREGORY-PAURON,M.H.REMY,C.CHEMIN,AUTH 2 B.RAYNAUD-MESSINA,C.BON,J.M.KOLLMAN,D.A.AGARD,A.MERDES,AUTH 3 L.MOUREYTITL CRYSTAL STRUCTURE OF GAMMA-TUBULIN COMPLEX PROTEIN GCP4TITL 2 PROVIDES INSIGHT INTO MICROTUBULE NUCLEATION.REF NAT.STRUCT.MOL.BIOL. V. 18 915 2011REFN ISSN 1545-9993PMID 21725292DOI 10.1038/NSMB.2083 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3phd HDAC6 crystal structure of human hdac6 in complex with ubiquitin 3.0Å AUTH H.OUYANG,Y.O.ALI,M.RAVICHANDRAN,A.DONG,W.QIU,F.MACKENZIE,AUTH 2 S.DHE-PAGANON,C.H.ARROWSMITH,R.G.ZHAITITL PROTEIN AGGREGATES ARE RECRUITED TO AGGRESOME BY HISTONETITL 2 DEACETYLASE 6 VIA UNANCHORED UBIQUITIN C TERMINI.REF J.BIOL.CHEM. V. 287 2317 2012REFN ISSN 0021-9258PMID 22069321DOI 10.1074/JBC.M111.273730 Variant Set Distributions Mapped Variants
General Structure Information 2dn6 SWAP70 solution structure of the ph domain of kiaa0640 protein from human -1.0Å AUTH H.LI,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF KIAA0640TITL 2 PROTEIN FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4cq1 PTBP2 crystal structure of the neuronal isoform of ptb 1.69Å AUTH A.JOSHI,V.ESTEVE,A.N.BUCKROYD,M.BLATTER,F.H.-T.ALLAIN,AUTH 2 S.CURRYTITL SOLUTION AND CRYSTAL STRUCTURES OF A C TERMINAL FRAGMENT OFTITL 2 THE NEURONAL ISOFORM OF THE POLYPYRIMIDINE TRACT BINDINGTITL 3 PROTEIN (NPTB)REF PEERJ V. 2 E211 2014REFN ISSN 2167-8359DOI 10.7287/PEERJ.PREPRINTS.211V1 Variant Set Distributions Mapped Variants