Assessment of Structural Intolerance and Durability
General Structure Information 2el8 STAP2 solution structure of the human stap2 sh2 domain -1.0Å AUTH T.KASAI,K.MIYAMOTO,N.TOCHIO,T.TOMIZAWA,S.KOSHIBA,AUTH 2 S.WATANABE,T.HARADA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HUMAN STAP2 SH2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1wf8 PPP1R9A solution structure of the pdz domain of spinophilin/neurabinii protein -1.0Å AUTH X.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PDZ DOMAIN OFTITL 2 SPINOPHILIN/NEURABINII PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1jn5 NXF1 structural basis for the recognition of a nucleoporin fg- repeat by the ntf2-like domain of tap-p15 mrna export factor 2.8Å AUTH S.FRIBOURG,I.C.BRAUN,E.IZAURRALDE,E.CONTITITL STRUCTURAL BASIS FOR THE RECOGNITION OF ATITL 2 NUCLEOPORIN FG REPEAT BY THE NTF2-LIKE DOMAIN OFTITL 3 THE TAP/P15 MRNA NUCLEAR EXPORT FACTOR.REF MOL.CELL V. 8 645 2001REFN […]
General Structure Information 4hxi KLHL3 crystal structure of klhl3/cul3 complex 3.51Å AUTH A.X.JI,G.G.PRIVETITL STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF KLHL3/CUL3TITL 2 COMPLEX AND IMPLICATIONS OF FHHT MUTATIONS IN CUL3 BINDINGREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1zv4 RGS17 structure of the regulator of g-protein signaling 17 (rgsz2) 2.4Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Mapped Variants
General Structure Information 2das ZMYM5 solution structure of trash domain of zinc finger mym-type protein 5 -1.0Å AUTH T.N.NIRAULA,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF TRASH DOMAIN OF ZINC FINGERTITL 2 MYM-TYPE PROTEIN 5REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ews DDX19B human dead-box rna-helicase ddx19 in complex with adp 2.7Å AUTH R.COLLINS,T.KARLBERG,L.LEHTIO,P.SCHUTZ,AUTH 2 S.VAN DEN BERG,L.G.DAHLGREN,M.HAMMARSTROM,AUTH 3 J.WEIGELT,H.SCHULERTITL THE DEXD/H-BOX RNA HELICASE DDX19 IS REGULATED BYTITL 2 AN {ALPHA}-HELICAL SWITCH.REF J.BIOL.CHEM. V. 284 10296 2009REFN ISSN 0021-9258PMID 19244245DOI 10.1074/JBC.C900018200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ox6 CABP1 crystal structure of the calcium sensor calcium-binding protein 1 (cabp1) 2.4Å AUTH F.FINDEISEN,D.L.MINORTITL STRUCTURAL BASIS FOR THE DIFFERENTIAL EFFECTS OF CABP1 ANDTITL 2 CALMODULIN ON CA(V)1.2 CALCIUM-DEPENDENT INACTIVATION.REF STRUCTURE V. 18 1617 2010REFN ISSN 0969-2126PMID 21134641DOI 10.1016/J.STR.2010.09.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1w24 VPS29 crystal structure of human vps29 2.1Å AUTH D.WANG,M.GUO,Z.LIANG,J.FAN,Z.ZHU,J.ZANG,Z.ZHU,X.LI,AUTH 2 M.TENG,L.NIU,Y.DONG,P.LIUTITL CRYSTAL STRUCTURE OF HUMAN VACUOLAR PROTEINTITL 2 SORTING PROTEIN 29 REVEALS ATITL 3 PHOSPHODIESTERASE/NUCLEASE-LIKE FOLD AND TWOTITL 4 PROTEIN-PROTEIN INTERACTION SITES.REF J.BIOL.CHEM. V. 280 22962 2005REFN ISSN 0021-9258PMID 15788412DOI 10.1074/JBC.M500464200 Variant Set Distributions Mapped Variants
General Structure Information 2mkd ZNF346 human jaz zf3 residues 168-227 -1.0Å AUTH R.G.BURGE,M.A.MARTINEZ-YAMOUT,H.J.DYSON,P.E.WRIGHTTITL STRUCTURAL CHARACTERIZATION OF INTERACTIONS BETWEEN THETITL 2 DOUBLE-STRANDED RNA-BINDING ZINC FINGER PROTEIN JAZ ANDTITL 3 NUCLEIC ACIDS.REF BIOCHEMISTRY V. 53 1495 2014REFN ISSN 0006-2960PMID 24521053DOI 10.1021/BI401675H Variant Set Distributions Mapped Variants