Assessment of Structural Intolerance and Durability
General Structure Information 3r90 MCTS1 crystal structure of malignant t cell-amplified sequence 1 protein 1.7Å AUTH B.HONG,S.DIMOV,W.TEMPEL,Y.TONG,A.K.WERNIMONT,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF MALIGNANT T CELL-AMPLIFIED SEQUENCE 1TITL 2 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1jkg NXT1 structural basis for the recognition of a nucleoporin fg- repeat by the ntf2-like domain of tap-p15 mrna nuclear export factor 1.9Å AUTH S.FRIBOURG,I.C.BRAUN,E.IZAURRALDE,E.CONTITITL STRUCTURAL BASIS FOR THE RECOGNITION OF ATITL 2 NUCLEOPORIN FG REPEAT BY THE NTF2-LIKE DOMAIN OFTITL 3 THE TAP/P15 MRNA NUCLEAR EXPORT FACTOR.REF MOL.CELL V. 8 645 […]
General Structure Information 2rb4 DDX25 crystal structure of the helicase domain of human ddx25 rna helicase 2.8Å AUTH P.SCHUTZ,T.KARLBERG,S.VAN DEN BERG,R.COLLINS,L.LEHTIO,AUTH 2 M.HOGBOM,L.HOLMBERG-SCHIAVONE,W.TEMPEL,H.W.PARK,AUTH 3 M.HAMMARSTROM,M.MOCHE,A.G.THORSELL,H.SCHULERTITL COMPARATIVE STRUCTURAL ANALYSIS OF HUMAN DEAD-BOX RNATITL 2 HELICASES.REF PLOS ONE V. 5 12791 2010REFN ESSN 1932-6203PMID 20941364DOI 10.1371/JOURNAL.PONE.0012791 Variant Set Distributions Mapped Variants
General Structure Information 4gmj CNOT7 structure of human not1 mif4g domain co-crystallized with caf1 2.7Å AUTH A.P.PETIT,L.WOHLBOLD,P.BAWANKAR,E.HUNTZINGER,S.SCHMIDT,AUTH 2 E.IZAURRALDE,O.WEICHENRIEDERTITL THE STRUCTURAL BASIS FOR THE INTERACTION BETWEEN THE CAF1TITL 2 NUCLEASE AND THE NOT1 SCAFFOLD OF THE HUMAN CCR4-NOTTITL 3 DEADENYLASE COMPLEXREF NUCLEIC ACIDS RES. V. 40 11058 2012REFN ISSN 0305-1048PMID 22977175DOI 10.1093/NAR/GKS883 Variant Set Distributions […]
General Structure Information 4avm BIN2 crystal structure of the n-bar domain of human bridging integrator 2. 1.91Å AUTH C.K.ALLERSTON,T.KROJER,C.D.O.COOPER,M.VOLLMAR,AUTH 2 C.H.ARROWSMITH,A.EDWARDS,C.BOUNTRA,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURE OF THE N-BAR DOMAIN OF HUMAN BRIDGINGTITL 2 INTEGRATOR 2.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kdg MYOT solution structure of the 1st ig domain of myotilin -1.0Å AUTH O.HEIKKINEN,P.PERMI,H.KOSKELA,O.CARPEN,J.YLANNE,AUTH 2 I.KILPELAINENTITL SOLUTION STRUCTURE OF THE FIRST IMMUNOGLOBULINTITL 2 DOMAIN OF HUMAN MYOTILINREF J.BIOMOL.NMR V. 44 107 2009REFN ISSN 0925-2738PMID 19418025DOI 10.1007/S10858-009-9320-4 Variant Set Distributions Mapped Variants
General Structure Information 4ch9 KLHL3 crystal structure of the human klhl3 kelch domain in complex with a wnk4 peptide 1.84Å AUTH F.SCHUMACHER,F.J.SORRELL,D.R.ALESSI,A.N.BULLOCK,T.KURZTITL STRUCTURAL AND BIOCHEMICAL CHARACTERISATION OF THE KLHL3-TITL 2 WNK KINASE INTERACTION IMPORTANT IN BLOOD PRESSURETITL 3 REGULATION.REF BIOCHEM.J. V. 460 237 2014REFN ISSN 0264-6021PMID 24641320DOI 10.1042/BJ20140153 Variant Set Distributions Mapped Variants
General Structure Information 3u10 HCN2 tetramerization dynamics of the c-terminus underlies isoform-specific camp-gating in hcn channels 2.3Å AUTH M.LOLICATO,M.NARDINI,S.GAZZARRINI,S.MOLLER,D.BERTINETTI,AUTH 2 F.W.HERBERG,M.BOLOGNESI,H.MARTIN,M.FASOLINI,J.A.BERTRAND,AUTH 3 C.ARRIGONI,G.THIEL,A.MORONITITL TETRAMERIZATION DYNAMICS OF C-TERMINAL DOMAIN UNDERLIESTITL 2 ISOFORM-SPECIFIC CAMP GATING IN HYPERPOLARIZATION-ACTIVATEDTITL 3 CYCLIC NUCLEOTIDE-GATED CHANNELS.REF J.BIOL.CHEM. V. 286 44811 2011REFN ISSN 0021-9258PMID 22006928DOI 10.1074/JBC.M111.297606 Variant Set Distributions Mapped Variants
General Structure Information 2los TMEM14C backbone structure of human membrane protein tmem14c -1.0Å AUTH C.KLAMMT,I.MASLENNIKOV,M.BAYRHUBER,C.EICHMANN,N.VAJPAI,AUTH 2 E.J.CHIU,K.Y.BLAIN,L.ESQUIVIES,J.H.KWON,B.BALANA,U.PIEPER,AUTH 3 A.SALI,P.A.SLESINGER,W.KWIATKOWSKI,R.RIEK,S.CHOETITL FACILE BACKBONE STRUCTURE DETERMINATION OF HUMAN MEMBRANETITL 2 PROTEINS BY NMR SPECTROSCOPY.REF NAT.METHODS V. 9 834 2012REFN ISSN 1548-7091PMID 22609626DOI 10.1038/NMETH.2033 Variant Set Distributions Mapped Variants
General Structure Information 2ltm NFU1 solution nmr structure of nfu1 iron-sulfur cluster scaffold homolog from homo sapiens, northeast structural genomics consortium (nesg) target hr2876b -1.0Å AUTH G.LIU,R.XIAO,H.JANJUA,K.HAMILTON,R.SHASTRY,E.KOHAN,AUTH 2 T.B.ACTON,J.K.EVERETT,H.LEE,Y.J.HUANG,G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF NFU1 IRON-SULFUR CLUSTER SCAFFOLDTITL 2 HOMOLOG FROM HOMO SAPIENS, NORTHEAST STRUCTURAL GENOMICSTITL 3 CONSORTIUM (NESG) TARGET HR2876BREF TO BE PUBLISHEDREFN Variant Set […]