General Structure Information
| PDB ID | 4avm |
| HGNC Gene Label(s) | BIN2 |
| Structure Name | crystal structure of the n-bar domain of human bridging integrator 2. |
| Resolution | 1.91Å |
| Reference | AUTH C.K.ALLERSTON,T.KROJER,C.D.O.COOPER,M.VOLLMAR,AUTH 2 C.H.ARROWSMITH,A.EDWARDS,C.BOUNTRA,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURE OF THE N-BAR DOMAIN OF HUMAN BRIDGINGTITL 2 INTEGRATOR 2.REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 230 |
| Number Of SNVs | 47 |
| Number Of Permutations | 15105 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.172 |
| p-value | 0.485 |
COSMIC
| Number Of Residues | 230 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1533 |
| Optimal Distance Threshold | 46.0 |
| K Statistic | 0.5 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 47 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 40.0 |
| K Statistic | -0.245 |
| p-value | 0.422 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
