Assessment of Structural Intolerance and Durability
General Structure Information 2rr3 VAPA solution structure of the complex between human vap-a msp domain and human osbp ffat motif -1.0Å AUTH K.FURUITA,J.JEE,H.FUKADA,M.MISHIMA,C.KOJIMATITL ELECTROSTATIC INTERACTION BETWEEN OXYSTEROL-BINDING PROTEINTITL 2 AND VAMP-ASSOCIATED PROTEIN A REVEALED BY NMR ANDTITL 3 MUTAGENESIS STUDIESREF J.BIOL.CHEM. V. 285 12961 2010REFN ISSN 0021-9258PMID 20178991DOI 10.1074/JBC.M109.082602 Variant Set Distributions Mapped Variants
General Structure Information 1ujk GGA1 vhs domain of human gga1 complexed with c-terminal phosphopeptide from bace 1.9Å AUTH T.SHIBA,S.KAMETAKA,M.KAWASAKI,M.SHIBATA,S.WAGURI,AUTH 2 Y.UCHIYAMA,S.WAKATSUKITITL INSIGHTS INTO THE PHOSPHOREGULATION OFTITL 2 BETA-SECRETASE SORTING SIGNAL BY THE VHS DOMAIN OFTITL 3 GGA1REF TRAFFIC V. 5 437 2004REFN ISSN 1398-9219PMID 15117318DOI 10.1111/J.1600-0854.2004.00188.X Variant Set Distributions Mapped Variants
General Structure Information 3twr TNKS2 crystal structure of arc4 from human tankyrase 2 in complex with peptide from human 3bp2 1.55Å AUTH S.GUETTLER,J.LAROSE,E.PETSALAKI,G.GISH,A.SCOTTER,T.PAWSON,AUTH 2 R.ROTTAPEL,F.SICHERITITL STRUCTURAL BASIS AND SEQUENCE RULES FOR SUBSTRATETITL 2 RECOGNITION BY TANKYRASE EXPLAIN THE BASIS FOR CHERUBISMTITL 3 DISEASE.REF CELL(CAMBRIDGE,MASS.) V. 147 1340 2011REFN ISSN 0092-8674PMID 22153077DOI 10.1016/J.CELL.2011.10.046 Variant Set Distributions […]
General Structure Information 3rqf PDCD10 cerebral cavernous malformation 3 (ccm3) in complex with paxillin ld2 2.7Å AUTH X.LI,W.JI,R.ZHANG,E.FOLTA-STOGNIEW,W.MIN,T.J.BOGGONTITL MOLECULAR RECOGNITION OF LEUCINE-ASPARTATE REPEAT (LD)TITL 2 MOTIFS BY THE FOCAL ADHESION TARGETING HOMOLOGY DOMAIN OFTITL 3 CEREBRAL CAVERNOUS MALFORMATION 3 (CCM3).REF J.BIOL.CHEM. V. 286 26138 2011REFN ISSN 0021-9258PMID 21632544DOI 10.1074/JBC.M110.211250 Variant Set Distributions Mapped Variants
General Structure Information 2l9s PHF12 solution structure of pf1 sid1-msin3a pah2 complex -1.0Å AUTH G.S.KUMAR,T.XIE,Y.ZHANG,I.RADHAKRISHNANTITL SOLUTION STRUCTURE OF THE MSIN3A PAH2-PF1 SID1 COMPLEX: ATITL 2 MAD1/MXD1-LIKE INTERACTION DISRUPTED BY MRG15 IN THETITL 3 RPD3S/SIN3S COMPLEX.REF J.MOL.BIOL. V. 408 987 2011REFN ISSN 0022-2836PMID 21440557DOI 10.1016/J.JMB.2011.03.043 Variant Set Distributions Mapped Variants
General Structure Information 1jh4 PAIP1 solution structure of the c-terminal pabc domain of human poly(a)-binding protein in complex with the peptide from paip1 -1.0Å AUTH G.KOZLOV,G.DE CRESCENZO,N.S.LIM,N.SIDDIQUI,AUTH 2 D.FANTUS,A.KAHVEJIAN,J.F.TREMPE,D.ELIAS,I.EKIEL,AUTH 3 N.SONENBERG,M.OCONNOR-MCCOURT,K.GEHRINGTITL STRUCTURAL BASIS OF LIGAND RECOGNITION BY PABC, ATITL 2 HIGHLY SPECIFIC PEPTIDE-BINDING DOMAIN FOUND INTITL 3 POLY(A)-BINDING PROTEIN AND A HECT UBIQUITIN LIGASEREF EMBO […]
General Structure Information 3f6k SORT1 crystal structure of the vps10p domain of human sortilin/nts3 in complex with neurotensin 2.0Å AUTH E.M.QUISTGAARD,P.MADSEN,M.K.GROFTEHAUGE,P.NISSEN,AUTH 2 C.M.PETERSEN,S.S.THIRUPTITL LIGANDS BIND TO SORTILIN IN THE TUNNEL OF A TEN-BLADEDTITL 2 BETA-PROPELLER DOMAIN.REF NAT.STRUCT.MOL.BIOL. V. 16 96 2009REFN ISSN 1545-9993PMID 19122660DOI 10.1038/NSMB.1543 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3k05 MDC1 the crystal structure of mdc1 brct t2067d in complex with a minimal recognition tetrapeptide with an amidated c-terminus 1.33Å AUTH S.J.CAMPBELL,R.A.EDWARDS,J.N.GLOVERTITL COMPARISON OF THE STRUCTURES AND PEPTIDE BINDINGTITL 2 SPECIFICITIES OF THE BRCT DOMAINS OF MDC1 AND BRCA1REF STRUCTURE V. 18 167 2010REFN ISSN 0969-2126PMID 20159462DOI 10.1016/J.STR.2009.12.008 Variant Set Distributions […]
General Structure Information 2c74 YWHAH 14-3-3 protein eta (human) complexed to peptide 2.7Å AUTH X.YANG,W.H.LEE,F.SOBOTT,E.PAPAGRIGORIOU,C.V.ROBINSON,AUTH 2 J.G.GROSSMANN,M.SUNDSTROM,D.A.DOYLE,J.M.ELKINSTITL STRUCTURAL BASIS FOR PROTEIN-PROTEIN INTERACTIONS IN THETITL 2 14-3-3 PROTEIN FAMILY.REF PROC.NATL.ACAD.SCI.USA V. 103 17237 2006REFN ISSN 0027-8424PMID 17085597DOI 10.1073/PNAS.0605779103 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ywh PLAUR crystal structure of urokinase plasminogen activator receptor 2.7Å AUTH P.LLINAS,M.H.LE DU,H.GARDSVOLL,K.DANO,M.PLOUG,B.GILQUIN,AUTH 2 E.A.STURA,A.MENEZTITL CRYSTAL STRUCTURE OF THE HUMAN UROKINASE PLASMINOGENTITL 2 ACTIVATOR RECEPTOR BOUND TO AN ANTAGONIST PEPTIDEREF EMBO J. V. 24 1655 2005REFN ISSN 0261-4189PMID 15861141DOI 10.1038/SJ.EMBOJ.7600635 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]