General Structure Information
| PDB ID | 2c74 |
| HGNC Gene Label(s) | YWHAH |
| Structure Name | 14-3-3 protein eta (human) complexed to peptide |
| Resolution | 2.7Å |
| Reference | AUTH X.YANG,W.H.LEE,F.SOBOTT,E.PAPAGRIGORIOU,C.V.ROBINSON,AUTH 2 J.G.GROSSMANN,M.SUNDSTROM,D.A.DOYLE,J.M.ELKINSTITL STRUCTURAL BASIS FOR PROTEIN-PROTEIN INTERACTIONS IN THETITL 2 14-3-3 PROTEIN FAMILY.REF PROC.NATL.ACAD.SCI.USA V. 103 17237 2006REFN ISSN 0027-8424PMID 17085597DOI 10.1073/PNAS.0605779103 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 234 |
| Number Of SNVs | 24 |
| Number Of Permutations | 4248 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.239 |
| p-value | 0.218 |
COSMIC
| Number Of Residues | 234 |
| Number Of SNVs | 3 |
| Number Of Permutations | 207 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | 0.333 |
| p-value | 0.973 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 24 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | -0.25 |
| p-value | 1.0 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
