Assessment of Structural Intolerance and Durability
General Structure Information 3ll8 PPP3CA crystal structure of calcineurin in complex with akap79 peptide 2.0Å AUTH H.LI,M.D.PINK,J.G.MURPHY,A.STEIN,M.L.DELLACQUA,P.G.HOGANTITL BALANCED INTERACTIONS OF CALCINEURIN WITH AKAP79 REGULATETITL 2 CA(2+)-CALCINEURIN-NFAT SIGNALING.REF NAT.STRUCT.MOL.BIOL. V. 19 337 2012REFN ISSN 1545-9993PMID 22343722DOI 10.1038/NSMB.2238 Variant Set Distributions Mapped Variants
General Structure Information 2obh XPC centrin-xpc peptide 1.8Å AUTH J.B.CHARBONNIER,E.RENAUD,S.MIRON,M.H.LE DU,Y.BLOUQUIT,AUTH 2 P.DUCHAMBON,P.CHRISTOVA,A.SHOSHEVA,T.ROSE,J.F.ANGULO,AUTH 3 C.T.CRAESCUTITL STRUCTURAL, THERMODYNAMIC, AND CELLULAR CHARACTERIZATION OFTITL 2 HUMAN CENTRIN 2 INTERACTION WITH XERODERMA PIGMENTOSUM GROUPTITL 3 C PROTEIN.REF J.MOL.BIOL. V. 373 1032 2007REFN ISSN 0022-2836PMID 17897675DOI 10.1016/J.JMB.2007.08.046 Variant Set Distributions Mapped Variants
General Structure Information 3zke DYNLL1 structure of lc8 in complex with nek9 peptide 2.2Å AUTH P.GALLEGO,A.VELAZQUEZ-CAMPOY,L.REGUE,J.ROIG,D.REVERTERTITL STRUCTURAL ANALYSIS OF THE REGULATION OF THE DYNLL/LC8TITL 2 BINDING TO NEK9 BY PHOSPHORYLATIONREF J.BIOL.CHEM. V. 288 12283 2013REFN ISSN 0021-9258PMID 23482567DOI 10.1074/JBC.M113.459149 Variant Set Distributions Mapped Variants
General Structure Information 1ywh PLAUR crystal structure of urokinase plasminogen activator receptor 2.7Å AUTH P.LLINAS,M.H.LE DU,H.GARDSVOLL,K.DANO,M.PLOUG,B.GILQUIN,AUTH 2 E.A.STURA,A.MENEZTITL CRYSTAL STRUCTURE OF THE HUMAN UROKINASE PLASMINOGENTITL 2 ACTIVATOR RECEPTOR BOUND TO AN ANTAGONIST PEPTIDEREF EMBO J. V. 24 1655 2005REFN ISSN 0261-4189PMID 15861141DOI 10.1038/SJ.EMBOJ.7600635 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3ll8 PPP3CA crystal structure of calcineurin in complex with akap79 peptide 2.0Å AUTH H.LI,M.D.PINK,J.G.MURPHY,A.STEIN,M.L.DELLACQUA,P.G.HOGANTITL BALANCED INTERACTIONS OF CALCINEURIN WITH AKAP79 REGULATETITL 2 CA(2+)-CALCINEURIN-NFAT SIGNALING.REF NAT.STRUCT.MOL.BIOL. V. 19 337 2012REFN ISSN 1545-9993PMID 22343722DOI 10.1038/NSMB.2238 Variant Set Distributions Mapped Variants
General Structure Information 2obh XPC centrin-xpc peptide 1.8Å AUTH J.B.CHARBONNIER,E.RENAUD,S.MIRON,M.H.LE DU,Y.BLOUQUIT,AUTH 2 P.DUCHAMBON,P.CHRISTOVA,A.SHOSHEVA,T.ROSE,J.F.ANGULO,AUTH 3 C.T.CRAESCUTITL STRUCTURAL, THERMODYNAMIC, AND CELLULAR CHARACTERIZATION OFTITL 2 HUMAN CENTRIN 2 INTERACTION WITH XERODERMA PIGMENTOSUM GROUPTITL 3 C PROTEIN.REF J.MOL.BIOL. V. 373 1032 2007REFN ISSN 0022-2836PMID 17897675DOI 10.1016/J.JMB.2007.08.046 Variant Set Distributions Mapped Variants
General Structure Information 3zke DYNLL1 structure of lc8 in complex with nek9 peptide 2.2Å AUTH P.GALLEGO,A.VELAZQUEZ-CAMPOY,L.REGUE,J.ROIG,D.REVERTERTITL STRUCTURAL ANALYSIS OF THE REGULATION OF THE DYNLL/LC8TITL 2 BINDING TO NEK9 BY PHOSPHORYLATIONREF J.BIOL.CHEM. V. 288 12283 2013REFN ISSN 0021-9258PMID 23482567DOI 10.1074/JBC.M113.459149 Variant Set Distributions Mapped Variants
General Structure Information 2p6b PPP3R1 crystal structure of human calcineurin in complex with pvivit peptide 2.3Å AUTH H.LI,L.ZHANG,A.RAO,S.C.HARRISON,P.G.HOGANTITL STRUCTURE OF CALCINEURIN IN COMPLEX WITH PVIVITTITL 2 PEPTIDE: PORTRAIT OF A LOW-AFFINITY SIGNALLINGTITL 3 INTERACTIONREF J.MOL.BIOL. V. 369 1296 2007REFN ISSN 0022-2836PMID 17498738DOI 10.1016/J.JMB.2007.04.032 Variant Set Distributions Mapped Variants
General Structure Information 4fu4 MMP13 human collagenase 3 (mmp-13) with peptide from pro-domain 2.85Å AUTH E.A.STURA,R.VISSE,P.CUNIASSE,V.DIVE,H.NAGASETITL CRYSTAL STRUCTURE OF FULL-LENGTH HUMAN COLLAGENASE 3TITL 2 (MMP-13) WITH PEPTIDES IN THE ACTIVE SITE DEFINES EXOSITESTITL 3 IN THE CATALYTIC DOMAIN.REF FASEB J. V. 27 4395 2013REFN ISSN 0892-6638PMID 23913860DOI 10.1096/FJ.13-233601 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4fu4 MMP13 human collagenase 3 (mmp-13) with peptide from pro-domain 2.85Å AUTH E.A.STURA,R.VISSE,P.CUNIASSE,V.DIVE,H.NAGASETITL CRYSTAL STRUCTURE OF FULL-LENGTH HUMAN COLLAGENASE 3TITL 2 (MMP-13) WITH PEPTIDES IN THE ACTIVE SITE DEFINES EXOSITESTITL 3 IN THE CATALYTIC DOMAIN.REF FASEB J. V. 27 4395 2013REFN ISSN 0892-6638PMID 23913860DOI 10.1096/FJ.13-233601 Variant Set Distributions Ripley’s K Analysis Plots […]