4ASX.A | ACVR2A

General Structure Information 4asx ACVR2A crystal structure of activin receptor type-iia (acvr2a) kinase domain in complex with dihydro-bauerine c 2.05Å AUTH E.WILLIAMS,A.CHAIKUAD,P.CANNING,P.MAHAJAN,C.D.O.COOPER,AUTH 2 A.BELTRAMI,T.KROJER,K.HUBER,F.BRACHER,F.VON DELFT,AUTH 3 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,A.BULLOCKTITL CRYSTAL STRUCTURE OF ACTIVIN RECEPTOR TYPE-IIA ( ACVR2A)TITL 2 KINASE DOMAIN IN COMPLEX WITH A BETA- CARBOLINE INHIBITORREF TO BE PUBLISHED Variant Set Distributions Ripley’s K Analysis Plots […]

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4L45.A | RPS6KB1

General Structure Information 4l45 RPS6KB1 crystal structures of human p70s6k1-t389e 2.9Å AUTH J.WANG,C.ZHONG,F.WANG,F.QU,J.DINGTITL CRYSTAL STRUCTURES OF S6K1 PROVIDE INSIGHTS INTO THETITL 2 REGULATION MECHANISM OF S6K1 BY THE HYDROPHOBIC MOTIFREF BIOCHEM.J. V. 454 39 2013REFN ISSN 0264-6021PMID 23731517DOI 10.1042/BJ20121863 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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3V5W.A | ADRBK1

General Structure Information 3v5w ADRBK1 human g protein-coupled receptor kinase 2 in complex with soluble gbetagamma subunits and paroxetine 2.07Å AUTH D.M.THAL,K.T.HOMAN,J.CHEN,E.K.WU,P.M.HINKLE,Z.M.HUANG,AUTH 2 J.K.CHUPRUN,J.SONG,E.GAO,J.Y.CHEUNG,L.A.SKLAR,W.J.KOCH,AUTH 3 J.J.TESMERTITL PAROXETINE IS A DIRECT INHIBITOR OF G PROTEIN-COUPLEDTITL 2 RECEPTOR KINASE 2 AND INCREASES MYOCARDIAL CONTRACTILITY.REF ACS CHEM.BIOL. V. 7 1830 2012REFN ISSN 1554-8929PMID 22882301DOI 10.1021/CB3003013 Variant Set Distributions […]

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4IVC.B | JAK1

General Structure Information 4ivc JAK1 jak1 kinase (jh1 domain) in complex with the inhibitor (trans-4-{2- [(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)- yl}cyclohexyl)acetonitrile 2.35Å AUTH M.ZAK,C.A.HURLEY,S.I.WARD,P.BERGERON,K.BARRETT,M.BALAZS,AUTH 2 W.S.BLAIR,R.BULL,P.CHAKRAVARTY,C.CHANG,P.CRACKETT,AUTH 3 G.DESHMUKH,J.DEVOSS,P.S.DRAGOVICH,C.EIGENBROT,C.ELLWOOD,AUTH 4 S.GAINES,N.GHILARDI,P.GIBBONS,S.GRADL,P.GRIBLING,C.HAMMAN,AUTH 5 E.HARSTAD,P.HEWITT,A.JOHNSON,T.JOHNSON,J.R.KENNY,AUTH 6 M.F.KOEHLER,P.BIR KOHLI,S.LABADIE,W.P.LEE,J.LIAO,M.LIIMATTA,AUTH 7 R.MENDONCA,R.NARUKULLA,R.PULK,A.REEVE,S.SAVAGE,S.SHIA,AUTH 8 M.STEFFEK,S.UBHAYAKAR,A.VAN ABBEMA,I.ALIAGAS,AUTH 9 B.AVITABILE-WOO,Y.XIAO,J.YANG,J.J.KULAGOWSKITITL IDENTIFICATION OF C-2 HYDROXYETHYL IMIDAZOPYRROLOPYRIDINESTITL 2 AS POTENT JAK1 INHIBITORS WITH FAVORABLE PHYSICOCHEMICALTITL 3 PROPERTIES AND HIGH […]

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1QU6.A | EIF2AK2

General Structure Information 1qu6 EIF2AK2 structure of the double-stranded rna-binding domain of the protein kinase pkr reveals the molecular basis of its dsrna-mediated activation -1.0Å AUTH S.NANDURI,B.W.CARPICK,Y.YANG,B.R.WILLIAMS,J.QINTITL STRUCTURE OF THE DOUBLE-STRANDED RNA-BINDINGTITL 2 DOMAIN OF THE PROTEIN KINASE PKR REVEALS THETITL 3 MOLECULAR BASIS OF ITS DSRNA-MEDIATED ACTIVATION.REF EMBO J. V. 17 5458 1998REFN ISSN […]

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2FGI.A | FGFR1

General Structure Information 2fgi FGFR1 crystal structure of the tyrosine kinase domain of fgf receptor 1 in complex with inhibitor pd173074 2.5Å AUTH M.MOHAMMADI,S.FROUM,J.M.HAMBY,M.C.SCHROEDER,AUTH 2 R.L.PANEK,G.H.LU,A.V.ELISEENKOVA,D.GREEN,AUTH 3 J.SCHLESSINGER,S.R.HUBBARDTITL CRYSTAL STRUCTURE OF AN ANGIOGENESIS INHIBITORTITL 2 BOUND TO THE FGF RECEPTOR TYROSINE KINASE DOMAIN.REF EMBO J. V. 17 5896 1998REFN ISSN 0261-4189PMID 9774334DOI 10.1093/EMBOJ/17.20.5896 Variant Set […]

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1VZO.A | RPS6KA5

General Structure Information 1vzo RPS6KA5 the structure of the n-terminal kinase domain of msk1 reveals a novel autoinhibitory conformation for a dual kinase protein 1.8Å AUTH K.J.SMITH,P.S.CARTER,A.BRIDGES,P.HORROCKS,C.LEWIS,AUTH 2 G.PETTMAN,A.CLARKE,M.BROWN,J.HUGHES,M.WILKINSON,AUTH 3 B.BAX,A.REITHTITL THE STRUCTURE OF MSK1 REVEALS A NOVELTITL 2 AUTOINHIBITORY CONFORMATION FOR A DUAL KINASETITL 3 PROTEINREF STRUCTURE V. 12 1066 2004REFN ISSN 0969-2126PMID 15274926DOI […]

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3MFT.A | CASK

General Structure Information 3mft CASK cask-4m cam kinase domain, mn2+ 2.2Å AUTH K.MUKHERJEE,M.SHARMA,R.JAHN,M.C.WAHL,T.C.SUDHOFTITL EVOLUTION OF CASK INTO A MG2+-SENSITIVE KINASE.REF SCI.SIGNAL. V. 3 RA33 2010REFN ESSN 1937-9145PMID 20424264DOI 10.1126/SCISIGNAL.2000800 Variant Set Distributions Mapped Variants

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