General Structure Information
| PDB ID | 4ivc |
| HGNC Gene Label(s) | JAK1 |
| Structure Name | jak1 kinase (jh1 domain) in complex with the inhibitor (trans-4-{2- [(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)- yl}cyclohexyl)acetonitrile |
| Resolution | 2.35Å |
| Reference | AUTH M.ZAK,C.A.HURLEY,S.I.WARD,P.BERGERON,K.BARRETT,M.BALAZS,AUTH 2 W.S.BLAIR,R.BULL,P.CHAKRAVARTY,C.CHANG,P.CRACKETT,AUTH 3 G.DESHMUKH,J.DEVOSS,P.S.DRAGOVICH,C.EIGENBROT,C.ELLWOOD,AUTH 4 S.GAINES,N.GHILARDI,P.GIBBONS,S.GRADL,P.GRIBLING,C.HAMMAN,AUTH 5 E.HARSTAD,P.HEWITT,A.JOHNSON,T.JOHNSON,J.R.KENNY,AUTH 6 M.F.KOEHLER,P.BIR KOHLI,S.LABADIE,W.P.LEE,J.LIAO,M.LIIMATTA,AUTH 7 R.MENDONCA,R.NARUKULLA,R.PULK,A.REEVE,S.SAVAGE,S.SHIA,AUTH 8 M.STEFFEK,S.UBHAYAKAR,A.VAN ABBEMA,I.ALIAGAS,AUTH 9 B.AVITABILE-WOO,Y.XIAO,J.YANG,J.J.KULAGOWSKITITL IDENTIFICATION OF C-2 HYDROXYETHYL IMIDAZOPYRROLOPYRIDINESTITL 2 AS POTENT JAK1 INHIBITORS WITH FAVORABLE PHYSICOCHEMICALTITL 3 PROPERTIES AND HIGH SELECTIVITY OVER JAK2.REF J.MED.CHEM. V. 56 4764 2013REFN ISSN 0022-2623PMID 23659214DOI 10.1021/JM4004895 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 280 |
| Number Of SNVs | 33 |
| Number Of Permutations | 5780 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.214 |
| p-value | 0.22 |
COSMIC
| Number Of Residues | 280 |
| Number Of SNVs | 3 |
| Number Of Permutations | 141 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.667 |
| p-value | 0.632 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 33 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | 0.455 |
| p-value | 0.58 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
