Assessment of Structural Intolerance and Durability
General Structure Information 1w50 BACE1 apo structure of bace (beta secretase) 1.75Å AUTH S.PATEL,L.VUILLARD,A.CLEASBY,C.W.MURRAY,J.YONTITL APO AND INHIBITOR COMPLEX STRUCTURES OF BACETITL 2 (BETA-SECRETASE)REF J.MOL.BIOL. V. 343 407 2004REFN ISSN 0022-2836PMID 15451669DOI 10.1016/J.JMB.2004.08.018 Variant Set Distributions Mapped Variants
General Structure Information 3dpr VLDLR human rhinovirus 2 bound to a concatamer of the vldl receptor module v3 3.5Å AUTH J.QUEROL-AUDI,T.KONECSNI,J.POUS,O.CARUGO,I.FITA,N.VERDAGUER,AUTH 2 D.BLAASTITL MINOR GROUP HUMAN RHINOVIRUS-RECEPTOR INTERACTIONS: GEOMETRYTITL 2 OF MULTIMODULAR ATTACHMENT AND BASIS OF RECOGNITIONREF FEBS LETT. V. 583 235 2009REFN ISSN 0014-5793PMID 19073182DOI 10.1016/J.FEBSLET.2008.12.014 Variant Set Distributions Mapped Variants
General Structure Information 3g76 XIAP crystal structure of xiap-bir3 in complex with a bivalent compound 3.0Å AUTH F.COSSU,M.MILANI,E.MASTRANGELO,P.VACHETTE,AUTH 2 F.SERVIDA,D.LECIS,G.CANEVARI,D.DELIA,C.DRAGO,AUTH 3 V.RIZZO,L.MANZONI,P.SENECI,C.SCOLASTICO,M.BOLOGNESITITL STRUCTURAL BASIS FOR BIVALENT SMAC-MIMETICSTITL 2 RECOGNITION IN THE IAP PROTEIN FAMILYREF J.MOL.BIOL. V. 392 630 2009REFN ISSN 0022-2836PMID 19393243DOI 10.1016/J.JMB.2009.04.033 Variant Set Distributions Mapped Variants
General Structure Information 3c7x MMP14 hemopexin-like domain of matrix metalloproteinase 14 1.7Å AUTH A.TOCHOWICZ,P.GOETTIG,R.EVANS,R.VISSE,Y.SHITOMI,R.PALMISANO,AUTH 2 N.ITO,K.RICHTER,K.MASKOS,D.FRANKE,D.SVERGUN,H.NAGASE,W.BODE,AUTH 3 Y.ITOHTITL THE DIMER INTERFACE OF THE MEMBRANE TYPE 1 MATRIXTITL 2 METALLOPROTEINASE HEMOPEXIN DOMAIN: CRYSTAL STRUCTURE ANDTITL 3 BIOLOGICAL FUNCTIONSREF J.BIOL.CHEM. V. 286 7587 2011REFN ISSN 0021-9258PMID 21193411DOI 10.1074/JBC.M110.178434 Variant Set Distributions Mapped Variants
General Structure Information 1rm8 MMP16 crystal structure of the catalytic domain of mmp-16/mt3- mmp: characterization of mt-mmp specific features 1.8Å AUTH R.LANG,M.BRAUN,N.E.SOUNNI,A.NOEL,F.FRANKENNE,AUTH 2 J.M.FOIDART,W.BODE,K.MASKOSTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OFTITL 2 MMP-16/MT3-MMP: CHARACTERIZATION OF MT-MMPTITL 3 SPECIFIC FEATURES.REF J.MOL.BIOL. V. 336 213 2004REFN ISSN 0022-2836PMID 14741217DOI 10.1016/J.JMB.2003.12.022 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3pdf CTSC discovery of novel cyanamide-based inhibitors of cathepsin c 1.85Å AUTH D.LAINE,M.PALOVICH,P.MCCLELAND,E.PETITJEAN,I.DELHOM,H.XIE,AUTH 2 J.DENG,G.LIN,R.DAVIS,A.JOLIT,N.NEVINS,J.VILLA,J.SCHNECKTITL DISCOVERY OF NOVEL CYANAMIDE-BASED INHIBITORS OF CATHEPSIN CREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1aye CPA2 human procarboxypeptidase a2 1.8Å AUTH I.GARCIA-SAEZ,D.REVERTER,J.VENDRELL,F.X.AVILES,AUTH 2 M.COLLTITL THE THREE-DIMENSIONAL STRUCTURE OF HUMANTITL 2 PROCARBOXYPEPTIDASE A2. DECIPHERING THE BASIS OFTITL 3 THE INHIBITION, ACTIVATION AND INTRINSIC ACTIVITYTITL 4 OF THE ZYMOGEN.REF EMBO J. V. 16 6906 1997REFN ISSN 0261-4189PMID 9384570DOI 10.1093/EMBOJ/16.23.6906 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4kkd MASP1 the x-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the 3mc syndrome 2.6Å AUTH T.YONGQING,P.G.WILMANN,S.B.REEVE,T.H.COETZER,A.I.SMITH,AUTH 2 J.C.WHISSTOCK,R.N.PIKE,L.C.WIJEYEWICKREMATITL THE X-RAY CRYSTAL STRUCTURE OF MANNOSE-BINDINGTITL 2 LECTIN-ASSOCIATED SERINE PROTEINASE-3 REVEALS THE STRUCTURALTITL 3 BASIS FOR ENZYME INACTIVITY ASSOCIATED WITH THE CARNEVALE,TITL 4 MINGARELLI, […]
General Structure Information 1mzd GZMK crystal structure of human pro-granzyme k 2.9Å AUTH C.HINK-SCHAUER,E.ESTEBANEZ-PERPINA,E.WILHARM,AUTH 2 P.FUENTES-PRIOR,W.KLINKERT,W.BODE,D.E.JENNETITL THE 2.2-A CRYSTAL STRUCTURE OF HUMAN PRO-GRANZYMETITL 2 K REVEALS A RIGID ZYMOGEN WITH UNUSUAL FEATURESREF J.BIOL.CHEM. V. 277 50923 2002REFN ISSN 0021-9258PMID 12384499DOI 10.1074/JBC.M207962200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2qxi KLK7 high resolution structure of human kallikrein 7 in complex with suc-ala-ala-pro-phe-chloromethylketone 1.0Å AUTH M.DEBELA,P.HESS,V.MAGDOLEN,N.M.SCHECHTER,T.STEINER,AUTH 2 R.HUBER,W.BODE,P.GOETTIGTITL CHYMOTRYPTIC SPECIFICITY DETERMINANTS IN THE 1.0 ATITL 2 STRUCTURE OF THE ZINC-INHIBITED HUMAN TISSUETITL 3 KALLIKREIN 7.REF PROC.NATL.ACAD.SCI.USA V. 104 16086 2007REFN ISSN 0027-8424PMID 17909180DOI 10.1073/PNAS.0707811104 Variant Set Distributions Ripley’s K Analysis Plots Variant […]