Assessment of Structural Intolerance and Durability
General Structure Information 3edh BMP1 crystal structure of bone morphogenetic protein 1 protease domain in complex with partially bound dmso 1.25Å AUTH A.MAC SWEENEY,S.G.PARRADO,D.VINZENZ,A.BERNARDI,AUTH 2 A.HEIN,U.BODENDORF,P.ERBEL,C.LOGEL,B.GERHARTZTITL STRUCTURAL BASIS FOR THE SUBSTRATE SPECIFICITY OFTITL 2 BONE MORPHOGENETIC PROTEIN 1/TOLLOID-LIKETITL 3 METALLOPROTEASESREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ifq JUP interction of plakoglobin and beta-catenin with desmosomal cadherins 2.8Å AUTH H.J.CHOI,J.C.GROSS,S.POKUTTA,W.I.WEISTITL INTERACTIONS OF PLAKOGLOBIN AND BETA-CATENIN WITHTITL 2 DESMOSOMAL CADHERINS: BASIS OF SELECTIVE EXCLUSIONTITL 3 OF ALPHA- AND BETA-CATENIN FROM DESMOSOMES.REF J.BIOL.CHEM. V. 284 31776 2009REFN ISSN 0021-9258PMID 19759396DOI 10.1074/JBC.M109.047928 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3fe1 HSPA6 crystal structure of the human 70kda heat shock protein 6 (hsp70b) atpase domain in complex with adp and inorganic phosphate 2.2Å AUTH M.WISNIEWSKA,T.KARLBERG,L.LEHTIO,I.JOHANSSON,AUTH 2 T.KOTENYOVA,M.MOCHE,H.SCHUELERTITL CRYSTAL STRUCTURES OF THE ATPASE DOMAINS OF FOURTITL 2 HUMAN HSP70 ISOFORMS: HSPA1L/HSP70-HOM,TITL 3 HSPA2/HSP70-2, HSPA6/HSP70B, AND HSPA5/BIP/GRP78REF PLOS ONE V. 5 E8625 2010REFN ESSN […]
General Structure Information 3e3b CSNK2A2 crystal structure of catalytic subunit of human protein kinase ck2alpha prime with a potent indazole-derivative inhibitor 3.2Å AUTH T.NAKANIWA,T.KINOSHITA,Y.SEKIGUCHI,T.TADA,AUTH 2 I.NAKANISHI,K.KITAURA,Y.SUZUKI,H.OHNO,A.HIRASAWA,AUTH 3 G.TSUJIMOTOTITL STRUCTURE OF HUMAN PROTEIN KINASE CK2ALPHA2 WITH ATITL 2 POTENT INDAZOLE-DERIVATIVE INHIBITORREF ACTA CRYSTALLOGR.,SECT.F V. 65 75 2009REFN ESSN 1744-3091PMID 19193990DOI 10.1107/S1744309108043194 Variant Set Distributions Ripley’s K […]
General Structure Information 2j0f TYMP structural basis for non-competitive product inhibition in human thymidine phosphorylase: implication for drug design 2.31Å AUTH K.EL OMARI,A.BRONCKAERS,S.LIEKENS,M.PEREZ-PEREZ,AUTH 2 J.BALZARINI,D.K.STAMMERSTITL STRUCTURAL BASIS FOR NON-COMPETITIVE PRODUCTTITL 2 INHIBITION IN HUMAN THYMIDINE PHOSPHORYLASE:TITL 3 IMPLICATIONS FOR DRUG DESIGN.REF BIOCHEM.J. V. 399 199 2006REFN ISSN 0264-6021PMID 16803458DOI 10.1042/BJ20060513 Variant Set Distributions Ripley’s K […]
General Structure Information 2iwg TRIM21 complex between the pryspry domain of trim21 and igg fc 2.35Å AUTH L.C.JAMES,A.H.KEEBLE,Z.KHAN,D.A.RHODES,J.TROWSDALETITL STRUCTURAL BASIS FOR PRYSPRY-MEDIATED TRIPARTITETITL 2 MOTIF (TRIM) PROTEIN FUNCTION.REF PROC.NATL.ACAD.SCI.USA V. 104 6200 2007REFN ISSN 0027-8424PMID 17400754DOI 10.1073/PNAS.0609174104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bu6 INSR crystal structure of the insulin receptor kinase in complex with irs2 krlb phosphopeptide 1.95Å AUTH J.WU,Y.D.TSENG,C.F.XU,T.A.NEUBERT,M.F.WHITE,AUTH 2 S.R.HUBBARDTITL STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF THETITL 2 KRLB REGION IN INSULIN RECEPTOR SUBSTRATE-2.REF NAT.STRUCT.MOL.BIOL. V. 15 251 2008REFN ISSN 1545-9993PMID 18278056DOI 10.1038/NSMB.1388 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2uzx MET structure of the human receptor tyrosine kinase met in complex with the listeria monocytogenes invasion protein inlb: crystal form i 2.8Å AUTH H.H.NIEMANN,V.JAGER,P.J.G.BUTLER,J.VAN DEN HEUVEL,AUTH 2 S.SCHMIDT,D.FERRARIS,E.GHERARDI,D.W.HEINZTITL STRUCTURE OF THE HUMAN RECEPTOR TYROSINE KINASETITL 2 MET IN COMPLEX WITH THE LISTERIA INVASION PROTEINTITL 3 INLBREF CELL(CAMBRIDGE,MASS.) V. 130 235 2007REFN […]
General Structure Information 2jdf CRYGB human gamma-b crystallin 1.7Å AUTH H.EBERSBACH,E.FIEDLER,T.SCHEUERMANN,M.FIEDLER,AUTH 2 M.T.STUBBS,C.REIMANN,G.PROETZEL,R.RUDOLPH,U.FIEDLERTITL AFFILIN-NOVEL BINDING MOLECULES BASED ON HUMANTITL 2 GAMMA-B-CRYSTALLIN, AN ALL BETA-SHEET PROTEIN.REF J.MOL.BIOL. V. 372 172 2007REFN ISSN 0022-2836PMID 17628592DOI 10.1016/J.JMB.2007.06.045 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ffn GSN crystal structure of calcium-free human gelsolin 3.0Å AUTH S.NAG,Q.MA,H.WANG,S.CHUMNARNSILPA,W.L.LEE,AUTH 2 M.LARSSON,B.KANNAN,M.HERNANDEZ-VALLADARES,AUTH 3 L.D.BURTNICK,R.C.ROBINSONTITL CA2+ BINDING BY DOMAIN 2 PLAYS A CRITICAL ROLE INTITL 2 THE ACTIVATION AND STABILIZATION OF GELSOLIN.REF PROC.NATL.ACAD.SCI.USA V. 106 13713 2009REFN ISSN 0027-8424PMID 19666512DOI 10.1073/PNAS.0812374106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]