Assessment of Structural Intolerance and Durability
General Structure Information 2ksr CHRNB2 nmr structures of tm domain of the n-acetylcholine receptor b2 subunit -1.0Å AUTH V.BONDARENKO,T.TILLMAN,Y.XU,P.TANGTITL NMR STRUCTURE OF THE TRANSMEMBRANE DOMAIN OF THETITL 2 N-ACETYLCHOLINE RECEPTOR BETA2 SUBUNIT.REF BIOCHIM.BIOPHYS.ACTA V.1798 1608 2010REFN ISSN 0006-3002PMID 20441771DOI 10.1016/J.BBAMEM.2010.04.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bk3 BMP2 crystal structure of the complex of bmp-2 and the first von willebrand domain type c of crossveinless-2 2.7Å AUTH J.-L.ZHANG,L.-Y.QIU,A.KOTZSCH,S.WEIDAUER,AUTH 2 L.PATTERSON,M.HAMMERSCHMIDT,W.SEBALD,T.D.MUELLERTITL CRYSTAL STRUCTURE ANALYSIS REVEALS HOW THE CHORDINTITL 2 FAMILY MEMBER CROSSVEINLESS 2 BLOCKS BMP-2TITL 3 RECEPTOR BINDINGREF DEV.CELL V. 14 739 2008REFN ISSN 1534-5807PMID 18477456DOI 10.1016/J.DEVCEL.2008.02.017 Variant Set […]
General Structure Information 2w2v RAC2 rac2 (g12v) in complex with gtpgs 2.0Å AUTH T.D.BUNNEY,O.OPALEYE,S.M.ROE,P.VATTER,AUTH 2 R.W.BAXENDALE,C.WALLISER,K.L.EVERETT,M.B.JOSEPHS,AUTH 3 C.CHRISTOW,F.RODRIGUES-LIMA,P.GIERSCHIK,L.H.PEARL,AUTH 4 M.KATANTITL STRUCTURAL INSIGHTS INTO FORMATION OF AN ACTIVETITL 2 SIGNALING COMPLEX BETWEEN RAC AND PHOSPHOLIPASE CTITL 3 GAMMA 2.REF MOL.CELL V. 34 223 2009REFN ISSN 1097-2765PMID 19394299DOI 10.1016/J.MOLCEL.2009.02.023 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3bhm CBR1 crystal structure of human carbonyl reductase 1 in complex with s-hydroxymethylglutathione 1.8Å AUTH R.L.BATEMAN,D.RAUH,B.TAVSHANJIAN,K.M.SHOKATTITL HUMAN CARBONYL REDUCTASE 1 IS ANTITL 2 S-NITROSOGLUTATHIONE REDUCTASEREF J.BIOL.CHEM. V. 283 35756 2008REFN ISSN 0021-9258PMID 18826943DOI 10.1074/JBC.M807125200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2vig ACADS crystal structure of human short-chain acyl coa dehydrogenase 1.9Å AUTH A.C.W.PIKE,N.PANTIC,E.PARIZOTTO,O.GILEADI,AUTH 2 E.UGOCHUKWU,F.VON DELFT,J.WEIGELT,C.H.ARROWSMITH,AUTH 3 A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN SHORT-CHAIN ACYL COATITL 2 DEHYDROGENASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2wk3 IDE crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-42) 2.59Å AUTH Q.GUO,M.MANOLOPOULOU,Y.BIAN,A.B.SCHILLING,W.J.TANGTITL MOLECULAR BASIS FOR THE RECOGNITION AND CLEAVAGESTITL 2 OF IGF-II, TGF-ALPHA, AND AMYLIN BY HUMAN INSULINTITL 3 DEGRADING ENZYME.REF J.MOL.BIOL. V. 395 430 2010REFN ISSN 0022-2836PMID 19896952DOI 10.1016/J.JMB.2009.10.072 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2krr NCL solution structure of the rbd1,2 domains from human nucleolin -1.0Å AUTH S.ARUMUGAM,M.C.MILLER,J.MALIEKAL,P.J.BATES,J.O.TRENT,AUTH 2 A.N.LANETITL SOLUTION STRUCTURE OF THE RBD1,2 DOMAINS FROM HUMANTITL 2 NUCLEOLIN.REF J.BIOMOL.NMR V. 47 79 2010REFN ISSN 0925-2738PMID 20376532DOI 10.1007/S10858-010-9412-1 Variant Set Distributions Mapped Variants
General Structure Information 3f7p ITGB4 crystal structure of a complex between integrin beta4 and plectin 2.75Å AUTH J.M.DE PEREDA,M.P.LILLO,A.SONNENBERGTITL STRUCTURAL BASIS OF THE INTERACTION BETWEENTITL 2 INTEGRIN ALPHA6BETA4 AND PLECTIN AT THETITL 3 HEMIDESMOSOMESREF EMBO J. V. 28 1180 2009REFN ISSN 0261-4189PMID 19242489DOI 10.1038/EMBOJ.2009.48 Variant Set Distributions Mapped Variants
General Structure Information 3ii5 BRAF the complex of wild-type b-raf with pyrazolo pyrimidine inhibitor 2.79Å AUTH D.M.BERGER,N.TORRES,M.DUTIA,D.POWELL,G.CISZEWSKI,AUTH 2 A.GOPALSAMY,J.I.LEVIN,K.H.KIM,W.XU,J.WILHELM,Y.HU,AUTH 3 K.COLLINS,L.FELDBERG,S.KIM,E.FROMMER,AUTH 4 D.WOJCIECHOWICZ,R.MALLONTITL NON-HINGE-BINDING PYRAZOLO[1,5-A]PYRIMIDINES ASTITL 2 POTENT B-RAF KINASE INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 19 6519 2009REFN ISSN 0960-894XPMID 19864136DOI 10.1016/J.BMCL.2009.10.049 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lpo SI crystal structure of the n-terminal domain of sucrase-isomaltase 3.2Å AUTH L.SIM,C.WILLEMSMA,S.MOHAN,H.Y.NAIM,B.M.PINTO,D.R.ROSETITL STRUCTURAL BASIS FOR SUBSTRATE SELECTIVITY IN HUMANTITL 2 MALTASE-GLUCOAMYLASE AND SUCRASE-ISOMALTASE N-TERMINALTITL 3 DOMAINS.REF J.BIOL.CHEM. V. 285 17763 2010REFN ISSN 0021-9258PMID 20356844DOI 10.1074/JBC.M109.078980 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants