Assessment of Structural Intolerance and Durability
General Structure Information 3bfx SULT1C2 crystal structure of human sulfotransferase sult1c1 in complex with pap 1.8Å AUTH L.DOMBROVSKI,A.DONG,A.BOCHKAREV,A.N.PLOTNIKOVTITL CRYSTAL STRUCTURES OF HUMAN SULFOTRANSFERASESTITL 2 SULT1B1 AND SULT1C1 COMPLEXED WITH THE COFACTORTITL 3 PRODUCT ADENOSINE-3-5-DIPHOSPHATE (PAP).REF PROTEINS V. 64 1091 2006REFN ISSN 0887-3585PMID 16804942DOI 10.1002/PROT.21048 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2krg SLC9A3R1 solution structure of human sodium/ hydrogen exchange regulatory factor 1(150-358) -1.0Å AUTH S.BHATTACHARYA,Z.DAI,J.LI,S.BAXTER,D.J.CALLAWAY,AUTH 2 D.COWBURN,Z.BUTITL A CONFORMATIONAL SWITCH IN THE SODIUM/ HYDROGENTITL 2 EXCHANGE REGULATORY FACTOR 1(NHERF1) CONTROLSTITL 3 AUTOINHIBITION AND COMPLEX FORMATION.REF J.BIOL.CHEM. 2010REFN ESSN 1083-351XPMID 20042604DOI 10.1074/JBC.M109.074005 Variant Set Distributions Mapped Variants
General Structure Information 3geb EYA2 crystal structure of edeya2 2.4Å AUTH S.J.KIM,D.G.JEONG,S.K.JUNG,E.R.SEONGTITL STRUCTURE OF EDEYA2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3llk QSOX1 sulfhydryl oxidase fragment of human qsox1 2.0Å AUTH A.ALON,E.J.HECKLER,C.THORPE,D.FASSTITL QSOX CONTAINS A PSEUDO-DIMER OF FUNCTIONAL AND DEGENERATETITL 2 SULFHYDRYL OXIDASE DOMAINS.REF FEBS LETT. V. 584 1521 2010REFN ISSN 0014-5793PMID 20211621DOI 10.1016/J.FEBSLET.2010.03.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3cok PLK4 crystal structure of plk4 kinase 2.25Å AUTH S.ATWELL,S.K.BURLEY,A.HOULE,B.LEON,L.A.PELLETIER,AUTH 2 J.M.SAUDERTITL CRYSTAL STRUCTURE OF PLK4 KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3h11 CFLAR zymogen caspase-8:c-flipl protease domain complex 1.9Å AUTH J.W.YU,P.D.JEFFREY,Y.SHITITL MECHANISM OF PROCASPASE-8 ACTIVATION BY C-FLIPL.REF PROC.NATL.ACAD.SCI.USA V. 106 8169 2009REFN ISSN 0027-8424PMID 19416807DOI 10.1073/PNAS.0812453106 Variant Set Distributions Mapped Variants
General Structure Information 2zg2 SIGLEC5 crystal structure of two n-terminal domains of native siglec-5 2.85Å AUTH M.A.ZHURAVLEVA,K.TRANDEM,P.D.SUNTITL STRUCTURAL IMPLICATIONS OF SIGLEC-5-MEDIATEDTITL 2 SIALOGLYCAN RECOGNITIONREF J.MOL.BIOL. V. 375 437 2008REFN ISSN 0022-2836PMID 18022638DOI 10.1016/J.JMB.2007.10.009 Variant Set Distributions Mapped Variants
General Structure Information 2wl1 MEFV pyrin pryspry domain 1.35Å AUTH C.WEINERT,C.GRUETTER,H.ROSCHITZKI-VOSER,P.R.MITTL,AUTH 2 M.G.GRUETTERTITL THE CRYSTAL STRUCTURE OF HUMAN PYRIN B30.2 DOMAIN:TITL 2 IMPLICATIONS FOR MUTATIONS ASSOCIATED WITHTITL 3 FAMILIAL MEDITERRANEAN FEVER.REF J.MOL.BIOL. V. 394 226 2009REFN ISSN 0022-2836PMID 19729025DOI 10.1016/J.JMB.2009.08.059 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vaf CASQ2 crystal structure of human cardiac calsequestrin 3.8Å AUTH E.KIM,B.YOUN,L.KEMPER,C.CAMPBELL,H.MILTING,AUTH 2 M.VARSANYI,C.KANGTITL CHARACTERIZATION OF HUMAN CARDIAC CALSEQUESTRINTITL 2 AND ITS DELETERIOUS MUTANTS.REF J.MOL.BIOL. V. 373 1047 2007REFN ISSN 0022-2836PMID 17881003DOI 10.1016/J.JMB.2007.08.055 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3l4v MGAM crystal complex of n-terminal human maltase-glucoamylase with kotalanol 2.1Å AUTH L.SIM,K.JAYAKANTHAN,S.MOHAN,R.NASI,B.D.JOHNSTON,AUTH 2 B.M.PINTO,D.R.ROSETITL NEW GLUCOSIDASE INHIBITORS FROM AN AYURVEDIC HERBALTITL 2 TREATMENT FOR TYPE 2 DIABETES: STRUCTURES ANDTITL 3 INHIBITION OF HUMAN INTESTINAL MALTASE-GLUCOAMYLASETITL 4 WITH COMPOUNDS FROM SALACIA RETICULATA.REF BIOCHEMISTRY V. 49 443 2010REFN ISSN 0006-2960PMID 20039683DOI 10.1021/BI9016457 Variant […]