Assessment of Structural Intolerance and Durability
General Structure Information 3kjo POT1 crystal structure of hpot1v2-dtrud(agggttag) 1.8Å AUTH J.NANDAKUMAR,E.R.PODELL,T.R.CECHTITL HOW TELOMERIC PROTEIN POT1 AVOIDS RNA TO ACHIEVETITL 2 SPECIFICITY FOR SINGLE-STRANDED DNA.REF PROC.NATL.ACAD.SCI.USA V. 107 651 2010REFN ISSN 0027-8424PMID 20080730DOI 10.1073/PNAS.0911099107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3b7b EHMT1 euhmt1 (glp) ankyrin repeat domain (structure 1) 2.99Å AUTH R.E.COLLINS,J.P.NORTHROP,J.R.HORTON,D.Y.LEE,AUTH 2 X.ZHANG,M.R.STALLCUP,X.CHENGTITL THE ANKYRIN REPEATS OF G9A AND GLP HISTONETITL 2 METHYLTRANSFERASES ARE MONO- AND DIMETHYLLYSINETITL 3 BINDING MODULESREF NAT.STRUCT.MOL.BIOL. V. 15 245 2008REFN ISSN 1545-9993PMID 18264113DOI 10.1038/NSMB.1384 Variant Set Distributions Mapped Variants
General Structure Information 2rfi EHMT1 crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with sah and dimethylated h3k9 peptide 1.59Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2wvr CDT1 human cdt1:geminin complex 3.3Å AUTH V.DE MARCO,P.J.GILLESPIE,A.LI,N.KARANTZELIS,AUTH 2 E.CHRISTODOULOU,R.KLOMPMAKER,S.VAN GERWEN,A.FISH,AUTH 3 M.V.PETOUKHOV,M.S.ILIOU,Z.LYGEROU,R.H.MEDEMA,AUTH 4 J.J.BLOW,D.I.SVERGUN,S.TARAVIRAS,A.PERRAKISTITL QUATERNARY STRUCTURE OF THE HUMAN CDT1-GEMININTITL 2 COMPLEX REGULATES DNA REPLICATION LICENSING.REF PROC.NATL.ACAD.SCI.USA V. 106 19807 2009REFN ISSN 0027-8424PMID 19906994DOI 10.1073/PNAS.0905281106 Variant Set Distributions Mapped Variants
General Structure Information 3if8 ZWILCH crystal structure of zwilch, a member of the rzz kinetochore complex 2.55Å AUTH F.CIVRIL,A.WEHENKEL,F.M.GIORGI,S.SANTAGUIDA,A.DI FONZO,AUTH 2 G.GRIGOREAN,F.D.CICCARELLI,A.MUSACCHIOTITL STRUCTURAL ANALYSIS OF THE RZZ COMPLEX REVEALS COMMONTITL 2 ANCESTRY WITH MULTISUBUNIT VESICLE TETHERING MACHINERY.REF STRUCTURE V. 18 616 2010REFN ISSN 0969-2126PMID 20462495DOI 10.1016/J.STR.2010.02.014 Variant Set Distributions Mapped Variants
General Structure Information 3if8 ZWILCH crystal structure of zwilch, a member of the rzz kinetochore complex 2.55Å AUTH F.CIVRIL,A.WEHENKEL,F.M.GIORGI,S.SANTAGUIDA,A.DI FONZO,AUTH 2 G.GRIGOREAN,F.D.CICCARELLI,A.MUSACCHIOTITL STRUCTURAL ANALYSIS OF THE RZZ COMPLEX REVEALS COMMONTITL 2 ANCESTRY WITH MULTISUBUNIT VESICLE TETHERING MACHINERY.REF STRUCTURE V. 18 616 2010REFN ISSN 0969-2126PMID 20462495DOI 10.1016/J.STR.2010.02.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3hai PACSIN1 crystal structure of human pacsin1 f-bar domain (p21 lattice) 2.88Å AUTH Q.WANG,M.V.NAVARRO,G.PENG,E.MOLINELLI,S.LIN GOH,AUTH 2 B.L.JUDSON,K.R.RAJASHANKAR,H.SONDERMANNTITL MOLECULAR MECHANISM OF MEMBRANE CONSTRICTION ANDTITL 2 TUBULATION MEDIATED BY THE F-BAR PROTEINTITL 3 PACSIN/SYNDAPIN.REF PROC.NATL.ACAD.SCI.USA V. 106 12700 2009REFN ISSN 0027-8424PMID 19549836DOI 10.1073/PNAS.0902974106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3dlq IL22 crystal structure of the il-22/il-22r1 complex 1.9Å AUTH L.BLEICHER,P.R.DE MOURA,L.WATANABE,D.COLAU,AUTH 2 L.DUMOUTIER,J.-C.RENAULD,I.POLIKARPOVTITL CRYSTAL STRUCTURE OF THE IL-22/IL-22R1 COMPLEX ANDTITL 2 ITS IMPLICATIONS FOR THE IL-22 SIGNALING MECHANISMREF FEBS LETT. V. 582 2985 2008REFN ISSN 0014-5793PMID 18675809DOI 10.1016/J.FEBSLET.2008.07.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2kk0 ARID3A solution structure of dead ringer-like protein 1 (at-rich interactive domain-containing protein 3a) from homo sapiens, northeast structural genomics consortium (nesg) target hr4394c -1.0Å AUTH G.LIU,Y.J.HUANG,R.XIAO,D.WANG,T.B.ACTON,G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF THE ARID DOMAIN OF HUMAN AT-RICHTITL 2 INTERACTIVE DOMAIN-CONTAINING PROTEIN 3A: A HUMAN CANCERTITL 3 PROTEIN INTERACTION NETWORK TARGET.REF PROTEINS V. […]
General Structure Information 2zix MUS81 crystal structure of the mus81-eme1 complex 3.5Å AUTH J.H.CHANG,J.J.KIM,J.M.CHOI,J.H.LEE,Y.CHOTITL CRYSTAL STRUCTURE OF THE MUS81-EME1 COMPLEXREF GENES DEV. V. 22 1093 2008REFN ISSN 0890-9369PMID 18413719DOI 10.1101/GAD.1618708 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants