Assessment of Structural Intolerance and Durability
General Structure Information 2wfd LARS structure of the human cytosolic leucyl-trna synthetase editing domain 3.25Å AUTH E.SEIRADAKE,W.MAO,V.HERNANDEZ,S.J.BAKER,AUTH 2 J.J.PLATTNER,M.R.K.ALLEY,S.CUSACKTITL CRYSTAL STRUCTURES OF THE HUMAN AND FUNGALTITL 2 CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAINS:TITL 3 A STRUCTURAL BASIS FOR THE RATIONAL DESIGN OFTITL 4 ANTIFUNGAL BENZOXABOROLES.REF J.MOL.BIOL. V. 390 196 2009REFN ISSN 0022-2836PMID 19426743DOI 10.1016/J.JMB.2009.04.073 Variant Set […]
General Structure Information 3in5 POLK structure of human dna polymerase kappa inserting datp opposite an 8-oxog dna lesion 3.2Å AUTH R.VASQUEZ-DEL CARPIO,T.D.SILVERSTEIN,S.LONE,AUTH 2 M.K.SWAN,J.R.CHOUDHURY,R.E.JOHNSON,S.PRAKASH,AUTH 3 L.PRAKASH,A.K.AGGARWALTITL STRUCTURE OF HUMAN DNA POLYMERASE KAPPA INSERTINGTITL 2 DATP OPPOSITE AN 8-OXOG DNA LESIONREF PLOS ONE V. 4 E5766 2009REFN ESSN 1932-6203PMID 19492058DOI 10.1371/JOURNAL.PONE.0005766 Variant Set Distributions Pathogenic Proximity […]
General Structure Information 2k40 HESX1 nmr structure of hesx-1 homeodomain double mutant r31l/e42l -1.0Å AUTH J.ASENSIO,M.TORRADO,C.GONZALEZ,A.BASTIDA,F.CORZANATITL THE ROLE OF CONSERVED SALT-BRIDGES ON HOMEODOMAINTITL 2 STABILITYREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2jw5 POLL polymerase lambda brct domain -1.0Å AUTH G.A.MUELLER,A.F.MOON,E.F.DEROSE,B.J.DAVIS,AUTH 2 D.A.RAMSDEN,L.C.PEDERSEN,R.E.LONDONTITL POLYMERASE LAMBDA BRCT DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3gls SIRT3 crystal structure of human sirt3 2.7Å AUTH L.JIN,W.WEI,Y.JIANG,H.PENG,J.CAI,C.MAO,H.DAI,AUTH 2 W.CHOY,J.E.BEMIS,M.R.JIROUSEK,J.C.MILNE,AUTH 3 C.H.WESTPHAL,R.B.PERNITITL CRYSTAL STRUCTURES OF HUMAN SIRT3 DISPLAYINGTITL 2 SUBSTRATE-INDUCED CONFORMATIONAL CHANGES.REF J.BIOL.CHEM. V. 284 24394 2009REFN ISSN 0021-9258PMID 19535340DOI 10.1074/JBC.M109.014928 Variant Set Distributions Mapped Variants
General Structure Information 3f1r FGF20 crystal structure of fgf20 dimer 2.5Å AUTH J.KALININA,S.A.BYRON,H.P.MAKARENKOVA,S.K.OLSEN,AUTH 2 A.V.ELISEENKOVA,W.J.LAROCHELLE,M.DHANABAL,S.BLAIS,AUTH 3 D.M.ORNITZ,L.A.DAY,T.A.NEUBERT,P.M.POLLOCK,AUTH 4 M.MOHAMMADITITL HOMODIMERIZATION CONTROLS THE FIBROBLAST GROWTHTITL 2 FACTOR 9 SUBFAMILYS RECEPTOR BINDING AND HEPARANTITL 3 SULFATE-DEPENDENT DIFFUSION IN THE EXTRACELLULARTITL 4 MATRIXREF MOL.CELL.BIOL. V. 29 4663 2009REFN ISSN 0270-7306PMID 19564416DOI 10.1128/MCB.01780-08 Variant Set Distributions Mapped Variants
General Structure Information 3l4g FARSB crystal structure of homo sapiens cytoplasmic phenylalanyl-trna synthetase 3.3Å AUTH I.FINAROV,N.MOOR,N.KESSLER,L.KLIPCAN,M.G.SAFROTITL STRUCTURE OF HUMAN CYTOSOLIC PHENYLALANYL-TRNA SYNTHETASE:TITL 2 EVIDENCE FOR KINGDOM-SPECIFIC DESIGN OF THE ACTIVE SITESTITL 3 AND TRNA BINDING PATTERNS.REF STRUCTURE V. 18 343 2010REFN ISSN 0969-2126PMID 20223217DOI 10.1016/J.STR.2010.01.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3iwp CUTC crystal structure of human copper homeostasis protein cutc 2.5Å AUTH Y.LI,J.DU,P.ZHANG,J.DINGTITL CRYSTAL STRUCTURE OF HUMAN COPPER HOMEOSTASISTITL 2 PROTEIN CUTC REVEALS A POTENTIAL COPPER-BINDINGTITL 3 SITEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2kea SAMSN1 nmr solution structure of the hacs1 sh3 domain -1.0Å AUTH L.DONALDSONTITL NMR SOLUTION STRUCTURE OF THE HACS1 SH3 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3hve GAN structures of spop-substrate complexes: insights into molecular architectures of btb-cul3 ubiquitin ligases: gigaxoninbtb/3-box 2.8Å AUTH M.ZHUANG,M.F.CALABRESE,J.LIU,M.B.WADDELL,A.NOURSE,AUTH 2 M.HAMMEL,D.J.MILLER,H.WALDEN,D.M.DUDA,S.N.SEYEDIN,AUTH 3 T.HOGGARD,J.W.HARPER,K.P.WHITE,B.A.SCHULMANTITL STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTSTITL 2 INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITINTITL 3 LIGASES.REF MOL.CELL V. 36 39 2009REFN ISSN 1097-2765PMID 19818708DOI 10.1016/J.MOLCEL.2009.09.022 Variant Set Distributions Ripley’s K Analysis Plots […]