General Structure Information
| PDB ID | 3kjo |
| HGNC Gene Label(s) | POT1 |
| Structure Name | crystal structure of hpot1v2-dtrud(agggttag) |
| Resolution | 1.8Å |
| Reference | AUTH J.NANDAKUMAR,E.R.PODELL,T.R.CECHTITL HOW TELOMERIC PROTEIN POT1 AVOIDS RNA TO ACHIEVETITL 2 SPECIFICITY FOR SINGLE-STRANDED DNA.REF PROC.NATL.ACAD.SCI.USA V. 107 651 2010REFN ISSN 0027-8424PMID 20080730DOI 10.1073/PNAS.0911099107 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 291 |
| Number Of SNVs | 38 |
| Number Of Permutations | 27728 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.031 |
| p-value | 0.668 |
ClinVar
| Number Of Residues | 291 |
| Number Of SNVs | 3 |
| Number Of Permutations | 299 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.667 |
| p-value | 0.402 |
COSMIC
| Number Of Residues | 291 |
| Number Of SNVs | 13 |
| Number Of Permutations | 3889 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.064 |
| p-value | 0.807 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 38 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.396 |
| p-value | 0.485 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 38 |
| Number Of COSMIC SNVs | 11 |
| Optimal Distance Threshold | 32.0 |
| K Statistic | 0.12 |
| p-value | 0.53 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
