Assessment of Structural Intolerance and Durability
General Structure Information 2k1v INSL5 r3/i5 relaxin chimera -1.0Å AUTH L.M.HAUGAARD-JONSSON,M.A.HOSSAIN,N.L.DALY,AUTH 2 R.A.BATHGATE,J.D.WADE,D.J.CRAIK,K.J.ROSENGRENTITL STRUCTURE OF THE R3/I5 CHIMERIC RELAXIN PEPTIDE, ATITL 2 SELECTIVE GPCR135 AND GPCR142 AGONIST.REF J.BIOL.CHEM. V. 283 23811 2008REFN ISSN 0021-9258PMID 18577524DOI 10.1074/JBC.M800489200 Variant Set Distributions Mapped Variants
General Structure Information 3bd0 MEMO1 crystal structure of memo, form ii 3.01Å AUTH C.QIU,S.LIENHARD,N.E.HYNES,A.BADACHE,D.J.LEAHYTITL MEMO IS HOMOLOGOUS TO NONHEME IRON DIOXYGENASESTITL 2 AND BINDS AN ERBB2-DERIVED PHOSPHOPEPTIDE IN ITSTITL 3 VESTIGIAL ACTIVE SITE.REF J.BIOL.CHEM. V. 283 2734 2008REFN ISSN 0021-9258PMID 18045866DOI 10.1074/JBC.M703523200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2kbc INSL5 solution structure of human insulin-like peptide 5 (insl5) -1.0Å AUTH M.A.HOSSAIN,N.L.DALY,D.J.CRAIK,J.D.WADE,AUTH 2 K.J.ROSENGRENTITL STRUCTURE OF HUMAN INSULIN-LIKE PEPTIDE 5 ANDTITL 2 CHARACTERIZATION OF CONSERVED HYDROGEN BONDS ANDTITL 3 ELECTROSTATIC INTERACTIONS WITHIN THE RELAXINTITL 4 FRAMEWORKREF BIOCHEM.J. V. 419 619 2009REFN ISSN 0264-6021PMID 19178384DOI 10.1042/BJ20082353 Variant Set Distributions Mapped Variants
General Structure Information 3gls SIRT3 crystal structure of human sirt3 2.7Å AUTH L.JIN,W.WEI,Y.JIANG,H.PENG,J.CAI,C.MAO,H.DAI,AUTH 2 W.CHOY,J.E.BEMIS,M.R.JIROUSEK,J.C.MILNE,AUTH 3 C.H.WESTPHAL,R.B.PERNITITL CRYSTAL STRUCTURES OF HUMAN SIRT3 DISPLAYINGTITL 2 SUBSTRATE-INDUCED CONFORMATIONAL CHANGES.REF J.BIOL.CHEM. V. 284 24394 2009REFN ISSN 0021-9258PMID 19535340DOI 10.1074/JBC.M109.014928 Variant Set Distributions Mapped Variants
General Structure Information 2iwz OXSM human mitochondrial beta-ketoacyl acp synthase complexed with hexanoic acid 1.65Å AUTH C.E.CHRISTENSEN,B.B.KRAGELUND,P.VON WETTSTEIN-KNOWLES,AUTH 2 A.HENRIKSENTITL STRUCTURE OF THE HUMAN BETA-KETOACYL [ACP] SYNTHASE FROMTITL 2 THE MITOCHONDRIAL TYPE II FATTY ACID SYNTHASE.REF PROTEIN SCI. V. 16 261 2007REFN ISSN 0961-8368PMID 17242430DOI 10.1110/PS.062473707 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4g1c SIRT5 human sirt5 bound to succ-idh2 and carba-nad 1.94Å AUTH B.G.SZCZEPANKIEWICZ,H.DAI,K.J.KOPPETSCH,D.QIAN,F.JIANG,AUTH 2 C.MAO,R.B.PERNITITL SYNTHESIS OF CARBA-NAD AND THE STRUCTURES OF ITS TERNARYTITL 2 COMPLEXES WITH SIRT3 AND SIRT5.REF J.ORG.CHEM. V. 77 7319 2012REFN ISSN 0022-3263PMID 22849721DOI 10.1021/JO301067E Variant Set Distributions Mapped Variants
General Structure Information 3t6j DPP3 structure of human dppiii in complex with the opioid peptide tynorphin, at 3.0 angstroms 2.98Å AUTH G.A.BEZERRA,E.DOBROVETSKY,R.VIERTLMAYR,A.DONG,A.BINTER,AUTH 2 M.ABRAMIC,P.MACHEROUX,S.DHE-PAGANON,K.GRUBERTITL ENTROPY-DRIVEN BINDING OF OPIOID PEPTIDES INDUCES A LARGETITL 2 DOMAIN MOTION IN HUMAN DIPEPTIDYL PEPTIDASE III.REF PROC.NATL.ACAD.SCI.USA V. 109 6525 2012REFN ISSN 0027-8424PMID 22493238DOI 10.1073/PNAS.1118005109 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4h87 SLC4A1AP crystal structure of a fha domain of kanadaptin (slc4a1ap) from homo sapiens at 1.55 a resolution 1.55Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG)TITL CRYSTAL STRUCTURE OF A FHA DOMAIN OF KANADAPTIN (SLC4A1AP)TITL 2 FROM HOMO SAPIENS AT 1.55 A RESOLUTIONREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2vcy MECR crystal structure of 2-enoyl thioester reductase of human fas ii 2.41Å AUTH Z.J.CHEN,R.PUDAS,S.SHARMA,O.S.SMART,A.H.JUFFER,AUTH 2 J.K.HILTUNEN,R.K.WIERENGA,A.M.HAAPALAINENTITL STRUCTURAL ENZYMOLOGICAL STUDIES OF 2-ENOYLTITL 2 THIOESTER REDUCTASE OF THE HUMAN MITOCHONDRIAL FASTITL 3 II PATHWAY: NEW INSIGHTS INTO ITS SUBSTRATETITL 4 RECOGNITION PROPERTIES.REF J.MOL.BIOL. V. 379 830 2008REFN ISSN 0022-2836PMID 18479707DOI 10.1016/J.JMB.2008.04.041 Variant Set […]
General Structure Information 2vx2 ECHDC3 crystal structure of human enoyl coenzyme a hydratase domain-containing protein 3 (echdc3) 2.3Å AUTH W.W.YUE,K.GUO,G.KOCHAN,E.PILKA,J.W.MURRAY,E.SALAH,R.COCKING,AUTH 2 Z.SUN,A.K.ROOS,A.C.W.PIKE,P.FILIPPAKOPOULOS,C.ARROWSMITH,AUTH 3 M.WIKSTROM,A.EDWARDS,C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN ENOYL COENZYME A HYDRATASETITL 2 DOMAIN-CONTAINING PROTEIN 3 (ECHDC3)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants