Assessment of Structural Intolerance and Durability
General Structure Information 2×36 LONP1 structure of the proteolytic domain of the human mitochondrial lon protease 2.0Å AUTH J.GARCIA-NAFRIA,G.ONDROVICOVA,E.BLAGOVA,AUTH 2 V.M.LEVDIKOV,J.A.BAUER,C.K.SUZUKI,E.KUTEJOVA,AUTH 3 A.J.WILKINSON,K.S.WILSONTITL STRUCTURE OF THE CATALYTIC DOMAIN OF THE HUMANTITL 2 MITOCHONDRIAL LON PROTEASE: PROPOSED RELATION OFTITL 3 OLIGOMER FORMATION AND ACTIVITY.REF PROTEIN SCI. V. 19 987 2010REFN ISSN 0961-8368PMID 20222013DOI 10.1002/PRO.376 Variant Set […]
General Structure Information 3d42 PTPN7 crystal structure of heptp in complex with a monophosphorylated erk2 peptide 2.46Å AUTH D.A.CRITTON,A.TORTAJADA,G.STETSON,W.PETI,R.PAGETITL STRUCTURAL BASIS OF SUBSTRATE RECOGNITION BY HEMATOPOIETICTITL 2 TYROSINE PHOSPHATASE.REF BIOCHEMISTRY V. 47 13336 2008REFN ISSN 0006-2960PMID 19053285DOI 10.1021/BI801724N Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3fdt CBX5 crystal structure of the complex of human chromobox homolog 5 (cbx5) with h3k9(me)3 peptide 2.0Å AUTH L.KAUSTOV,H.OUYANG,M.AMAYA,A.LEMAK,N.NADY,S.DUAN,G.A.WASNEY,AUTH 2 Z.LI,M.VEDADI,M.SCHAPIRA,J.MIN,C.H.ARROWSMITHTITL RECOGNITION AND SPECIFICITY DETERMINANTS OF THE HUMAN CBXTITL 2 CHROMODOMAINS.REF J.BIOL.CHEM. V. 286 521 2011REFN ISSN 0021-9258PMID 21047797DOI 10.1074/JBC.M110.191411 Variant Set Distributions Mapped Variants
General Structure Information 2l27 CRHR1 nmr structure of the ecd1 of crf-r1 in complex with a peptide agonist -1.0Å AUTH C.R.GRACE,M.H.PERRIN,J.GULYAS,J.E.RIVIER,W.W.VALE,R.RIEKTITL NMR STRUCTURE OF THE FIRST EXTRACELLULAR DOMAIN OFTITL 2 CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1 (ECD1-CRF-R1)TITL 3 COMPLEXED WITH A HIGH AFFINITY AGONIST.REF J.BIOL.CHEM. V. 285 38580 2010REFN ISSN 0021-9258PMID 20843795DOI 10.1074/JBC.M110.121897 Variant Set Distributions Mapped […]
General Structure Information 2c0l SCP2 tpr domain of human pex5p in complex with human mscp2 2.3Å AUTH W.A.STANLEY,F.V.FILIPP,P.KURSULA,N.SCHULLER,AUTH 2 R.ERDMANN,W.SCHLIEBS,M.SATTLER,M.WILMANNSTITL RECOGNITION OF A FUNCTIONAL PEROXISOME TYPE 1TITL 2 TARGET BY THE DYNAMIC IMPORT RECEPTOR PEX5P.REF MOL.CELL V. 24 653 2006REFN ISSN 1097-2765PMID 17157249DOI 10.1016/J.MOLCEL.2006.10.024 Variant Set Distributions Mapped Variants
General Structure Information 3pos CALR crystal structure of the globular domain of human calreticulin 1.65Å AUTH A.CHOUQUET,H.PAIDASSI,W.L.LING,P.FRACHET,G.HOUEN,G.J.ARLAUD,AUTH 2 C.GABORIAUDTITL X-RAY STRUCTURE OF THE HUMAN CALRETICULIN GLOBULAR DOMAINTITL 2 REVEALS A PEPTIDE-BINDING AREA AND SUGGESTS ATITL 3 MULTI-MOLECULAR MECHANISMREF PLOS ONE V. 6 E1788 2011REFN ESSN 1932-6203PMID 21423620DOI 10.1371/JOURNAL.PONE.0017886 Variant Set Distributions Mapped Variants