3T6J.A | DPP3 – ASTRID

3T6J.A | DPP3

General Structure Information

PDB ID	3t6j
HGNC Gene Label(s)	DPP3
Structure Name	structure of human dppiii in complex with the opioid peptide tynorphin, at 3.0 angstroms
Resolution	2.98Å
Reference	AUTH G.A.BEZERRA,E.DOBROVETSKY,R.VIERTLMAYR,A.DONG,A.BINTER,AUTH 2 M.ABRAMIC,P.MACHEROUX,S.DHE-PAGANON,K.GRUBERTITL ENTROPY-DRIVEN BINDING OF OPIOID PEPTIDES INDUCES A LARGETITL 2 DOMAIN MOTION IN HUMAN DIPEPTIDYL PEPTIDASE III.REF PROC.NATL.ACAD.SCI.USA V. 109 6525 2012REFN ISSN 0027-8424PMID 22493238DOI 10.1073/PNAS.1118005109

Variant Set Distributions

ExAC Variants

Number Of Residues	722
Number Of SNVs	209
Number Of Permutations	37641
Optimal Distance Threshold	13.0
K Statistic	0.05
p-value	0.399

COSMIC

Number Of Residues	722
Number Of SNVs	6
Number Of Permutations	2584
Optimal Distance Threshold	27.0
K Statistic	0.133
p-value	0.616

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	209
Number Of COSMIC SNVs	6
Optimal Distance Threshold	33.0
K Statistic	-0.35
p-value	0.09

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
11:66249676	rs145932032	A>V	A:2	(-36.03, -23.84, -5.86)
11:66249690		I>L	A:7	(-41.78, -17.42, -4.53)
11:66249700	rs200777816	N>S	A:10	(-50.66, -15.72, -4.94)
11:66249705	rs149689390	I>V	A:12	(-50.07, -17.38, 1.35)
11:66249711	rs201828080	V>M	A:14	(-53.66, -14.22, 5.90)
11:66249725		D>E	A:18	(-58.26, -11.20, 18.03)
11:66249729	rs200657045 COSM930760	R>C	A:20	(-61.92, -5.97, 19.99)
11:66249730	rs139018330	R>H	A:20	(-61.92, -5.97, 19.99)
11:66249735	rs199998254	A>T	A:22	(-58.12, -7.07, 26.07)
11:66249736	rs142478050	A>V	A:22	(-58.12, -7.07, 26.07)
11:66249741	rs201658473 COSM4035730	R>C	A:24	(-63.27, -4.02, 26.41)
11:66249742		R>H	A:24	(-63.27, -4.02, 26.41)
11:66249750		S>T	A:27	(-58.59, 1.69, 31.79)
11:66249754	rs200857844	P>L	A:28	(-57.88, 4.95, 30.04)
11:66249763		R>H	A:31	(-56.90, 1.78, 26.48)
11:66249769	COSM1356220	Y>C	A:33	(-48.09, 1.31, 29.98)
11:66249787	rs557697442	R>H	A:39	(-46.42, 5.80, 18.24)
11:66249792		A>T	A:41	(-41.90, -0.54, 18.68)
11:66249796		W>S	A:42	(-45.13, -0.99, 15.18)
11:66249802		G>E	A:44	(-37.69, 0.32, 15.69)
11:66249804		G>S	A:45	(-38.51, -2.06, 13.62)
11:66249813	rs11550300	V>L	A:48	(-35.12, -5.07, 10.87)
11:66249841		P>L	A:57	(-34.46, 0.04, 3.27)
11:66249846		I>V	A:59	(-38.02, -2.19, -0.82)
11:66249852	rs114567543	A>S	A:61	(-40.18, 3.28, 0.84)
11:66249864	rs575752647	R>C	A:65	(-43.51, 7.31, -1.01)
11:66249865	rs202184719	R>H	A:65	(-43.51, 7.31, -1.01)
11:66249876	rs577731291	A>T	A:69	(-51.25, 6.86, -3.40)
11:66249880	rs371108340	Q>R	A:70	(-52.59, 4.16, -5.72)
11:66249890		D>E	A:73	(-58.68, -1.67, -4.18)
11:66249897	rs199654699	R>C	A:76	(-56.59, -4.16, -8.02)
11:66249898	rs11826683	R>H	A:76	(-56.59, -4.16, -8.02)
11:66249927	rs201636331	E>K	A:86	(-55.37, -10.31, -10.49)
11:66249930	rs150218434	E>K	A:87	(-52.47, -14.36, -12.18)
11:66249937		Y>F	A:89	(-51.76, -6.23, -8.14)
11:66252653	rs200221391	V>L	A:94	(-47.82, -11.31, -1.65)
11:66252662		A>T	A:97	(-46.80, -8.21, 2.79)
11:66252663	rs202120263 COSM4035732	A>V	A:97	(-46.80, -8.21, 2.79)
11:66252681		M>T	A:103	(-39.48, -5.55, 8.41)
11:66252686		N>H	A:105	(-35.91, -9.25, 1.21)
11:66252690	rs201297516	Y>F	A:106	(-33.53, -11.97, 2.84)
11:66252705		D>G	A:111	(-32.68, -16.74, 7.31)
11:66252711		K>R	A:113	(-33.89, -13.43, -1.38)
11:66252712		K>N	A:113	(-33.89, -13.43, -1.38)
11:66254023	rs145463220	R>W	A:125	(-45.35, -1.21, -17.74)
11:66254032		L>I	A:128	(-42.78, 4.38, -13.24)
11:66254041		E>K	A:131	(-50.91, 9.01, -8.67)
11:66254042	rs145950613	E>G	A:131	(-50.91, 9.01, -8.67)
11:66254085	rs11550299	Q>H	A:145	(-31.98, 3.26, -10.78)
11:66254092	rs141227407	G>R	A:148	(-34.79, -3.18, -8.08)
11:66254095		E>K	A:149	(-31.63, -5.44, -10.27)
11:66254098	rs150741952	L>F	A:150	(-31.14, -6.31, -5.14)
11:66254116		P>A	A:156	(-26.35, -17.55, -6.28)
11:66254126		R>Q	A:159	(-30.12, -18.02, -4.10)
11:66254128		H>Y	A:160	(-29.05, -18.52, 0.98)
11:66254137	rs112484606	L>M	A:163	(-20.26, -14.18, 6.92)
11:66254752	rs200360094	Y>C	A:171	(-26.24, -8.10, 12.03)
11:66254769		T>A	A:177	(-14.90, -13.38, 6.96)
11:66254772		M>V	A:178	(-16.72, -16.33, 10.49)
11:66254773	rs149825536	M>T	A:178	(-16.72, -16.33, 10.49)
11:66254788		L>S	A:183	(-10.69, -10.96, 15.93)
11:66254802		L>V	A:188	(-16.22, -7.44, 21.85)
11:66254811		Q>E	A:191	(-12.55, -4.28, 26.47)
11:66255395		A>V	A:195	(-22.89, -8.00, 20.81)
11:66255407		R>Q	A:199	(-23.93, -3.03, 12.47)
11:66255413		F>S	A:201	(-19.24, -1.85, 9.88)
11:66255424		D>N	A:205	(-5.37, 0.72, 3.54)
11:66255439	rs140206368	P>S	A:210	(-7.32, -4.63, 8.17)
11:66255440	rs200798950	P>L	A:210	(-7.32, -4.63, 8.17)
11:66255443		Y>F	A:211	(-7.80, -0.21, 9.19)
11:66255448	rs201608803 COSM194401	E>K	A:213	(-16.58, 0.65, 12.49)
11:66255449	rs145645260	E>V	A:213	(-16.58, 0.65, 12.49)
11:66255454		R>W	A:215	(-21.68, 1.38, 13.78)
11:66255455		R>Q	A:215	(-21.68, 1.38, 13.78)
11:66258726	COSM3869954	P>S	A:224	(-19.50, 15.98, 22.91)
11:66258774		R>W	A:240	(-4.82, -10.37, 18.27)
11:66258775	COSM3452092	R>Q	A:240	(-4.82, -10.37, 18.27)
11:66258781		S>N	A:242	(-5.53, -5.21, 14.08)
11:66258783		P>S	A:243	(-6.98, -1.71, 13.88)
11:66258798	COSM544778	R>W	A:248	(-22.14, 6.72, 20.44)
11:66258799		R>Q	A:248	(-22.14, 6.72, 20.44)
11:66258810	rs200834438 COSM1509634	A>T	A:252	(-30.38, 7.54, 15.59)
11:66258811		A>V	A:252	(-30.38, 7.54, 15.59)
11:66258813	rs149136081	P>S	A:253	(-33.11, 8.77, 14.11)
11:66258814	rs142252193	P>L	A:253	(-33.11, 8.77, 14.11)
11:66258827		K>N	A:257	(-39.02, 9.09, 16.78)
11:66258828	rs374869903	V>L	A:258	(-38.18, 4.96, 20.51)
11:66258838		Q>R	A:261	(-43.15, 7.37, 21.96)
11:66258846		K>E	A:264	(-44.29, 10.07, 25.84)
11:66258848		K>N	A:264	(-44.29, 10.07, 25.84)
11:66258850		A>V	A:265	(-44.96, 5.62, 28.84)
11:66258965	rs151275489	A>T	A:267	(-46.71, 8.54, 33.47)
11:66258969	rs140484665	Y>C	A:268	(-49.34, 7.30, 31.02)
11:66258999		L>Q	A:278	(-39.26, 2.58, 30.62)
11:66259001	rs200633983	A>S	A:279	(-35.56, 5.13, 31.66)
11:66259005		Q>R	A:280	(-32.79, 2.45, 32.90)
11:66259012	rs201933676	I>M	A:282	(-34.33, 5.87, 27.59)
11:66259014		E>A	A:283	(-29.36, 5.71, 29.56)
11:66259029		G>A	A:288	(-25.45, 2.47, 24.10)
11:66259037	rs368941305	E>K	A:291	(-24.99, -2.47, 31.74)
11:66259043	rs199804365	H>Y	A:293	(-31.79, -3.40, 28.25)
11:66259052		G>S	A:296	(-34.67, -2.94, 33.26)
11:66259058	rs200561011	R>C	A:298	(-31.70, -7.05, 37.11)
11:66259059	rs201367893 COSM930763	R>H	A:298	(-31.70, -7.05, 37.11)
11:66259080	rs199675857	G>V	A:305	(-48.87, -8.83, 37.02)
11:66259095		S>N	A:310	(-43.51, -4.75, 27.94)
11:66259176	rs200788432	G>R	A:313	(-34.69, -4.50, 21.81)
11:66259185	rs201264826	E>K	A:316	(-33.90, -12.91, 20.40)
11:66259187	rs201209726	E>D	A:316	(-33.90, -12.91, 20.40)
11:66259210	rs371241781	S>F	A:324	(-23.86, -12.24, 18.82)
11:66259213		R>Q	A:325	(-23.51, -9.30, 16.44)
11:66260192	rs200473591 COSM4035735	V>I	A:332	(-47.30, -4.19, 23.69)
11:66260217		S>N	A:340	(-52.63, -17.49, 33.35)
11:66260231		R>W	A:345	(-52.23, -24.99, 37.55)
11:66260232	rs200517626	R>Q	A:345	(-52.23, -24.99, 37.55)
11:66260246	rs138546620	A>T	A:350	(-41.68, -26.20, 39.27)
11:66260249	rs367914018	E>Q	A:351	(-40.62, -26.51, 43.01)
11:66260267	rs149246925	L>V	A:357	(-33.43, -32.76, 35.14)
11:66260299	COSM167775	K>N	A:367	(-32.68, -19.99, 43.36)
11:66260330		V>I	A:378	(-50.51, -9.59, 21.08)
11:66260342	rs200126600	A>S	A:382	(-42.11, -5.58, 16.34)
11:66260351	rs202008504 COSM1704267	G>S	A:385	(-41.69, -11.85, 14.46)
11:66260373		I>T	A:392	(-36.98, -12.99, 28.34)
11:66260379		N>S	A:394	(-31.62, -13.25, 26.35)
11:66260544		D>G	A:397	(-26.52, -13.26, 34.35)
11:66260550		R>T	A:399	(-31.79, -16.40, 32.31)
11:66260552		Q>E	A:400	(-28.19, -17.42, 37.22)
11:66260574		V>A	A:407	(-44.19, -15.37, 27.52)
11:66260577	rs199834297	S>L	A:408	(-47.83, -17.70, 26.49)
11:66260588		V>M	A:412	(-50.72, -16.43, 18.42)
11:66260600		A>S	A:416	(-52.38, -21.26, 14.42)
11:66260603		Y>N	A:417	(-54.68, -23.81, 16.07)
11:66260615		R>W	A:421	(-57.02, -34.87, 6.91)
11:66260616		R>Q	A:421	(-57.02, -34.87, 6.91)
11:66260619		E>G	A:422	(-55.04, -31.96, 2.23)
11:66260622	rs377028801	K>R	A:423	(-52.08, -28.88, 4.27)
11:66260642		D>Y	A:430	(-54.57, -43.21, 11.63)
11:66261021	rs370786570	I>V	A:436	(-56.69, -32.63, 14.13)
11:66261034		G>A	A:440	(-53.22, -27.69, 20.63)
11:66261040		S>F	A:442	(-49.75, -30.30, 23.29)
11:66261045		D>H	A:444	(-50.31, -25.12, 25.56)
11:66261066		E>K	A:451	(-39.89, -21.96, 28.78)
11:66261078		H>N	A:455	(-34.68, -21.94, 28.27)
11:66261082		G>D	A:456	(-34.56, -22.77, 33.56)
11:66261099	rs201554759	V>I	A:462	(-18.32, -18.40, 35.88)
11:66262690	COSM1492694	A>E	A:468	(-12.54, -17.74, 42.43)
11:66262696		N>S	A:470	(-19.87, -19.66, 40.55)
11:66262711	rs147328602	T>I	A:475	(-17.88, -30.78, 45.58)
11:66262729	rs200655168	T>M	A:481	(-15.77, -37.99, 33.05)
11:66262732	rs200403555	G>D	A:482	(-15.18, -38.33, 36.80)
11:66262849	rs201288479	Y>C	A:489	(-19.11, -20.29, 30.75)
11:66262852	rs148964668	R>Q	A:490	(-12.04, -18.39, 32.00)
11:66262881	rs201439382	S>C	A:500	(-21.55, -19.35, 18.17)
11:66262890	rs369936005	A>T	A:503	(-25.83, -21.60, 20.69)
11:66262903		E>G	A:507	(-30.54, -23.91, 24.62)
11:66262911	COSM293256	R>W	A:510	(-31.43, -27.47, 27.12)
11:66262919		E>D	A:512	(-37.77, -28.66, 22.04)
11:66262929	rs144272479	L>F	A:516	(-40.31, -34.53, 24.82)
11:66262932		Y>H	A:517	(-37.36, -36.24, 30.54)
11:66262938		C>S	A:519	(-44.22, -34.77, 28.34)
11:66262944	rs34504069	H>Y	A:521	(-44.82, -36.20, 35.07)
11:66262948	rs373434247	P>L	A:522	(-48.00, -37.73, 35.14)
11:66262953	rs376310826	V>M	A:524	(-47.65, -31.81, 33.53)
11:66262956		L>M	A:525	(-50.62, -34.32, 31.66)
11:66262957		L>R	A:525	(-50.62, -34.32, 31.66)
11:66262959		E>K	A:526	(-53.73, -33.42, 36.47)
11:66263112		F>S	A:530	(-54.28, -33.37, 29.43)
11:66263120		A>T	A:533	(-58.19, -41.31, 27.67)
11:66263124	rs201694123	D>V	A:534	(-57.01, -37.81, 27.76)
11:66263126		A>T	A:535	(-52.54, -39.07, 28.70)
11:66263127	rs140995720	A>V	A:535	(-52.54, -39.07, 28.70)
11:66263132	rs200316177 COSM1250650	D>Y	A:537	(-53.53, -39.32, 23.01)
11:66263142	rs370457434	Y>S	A:540	(-48.20, -40.50, 19.34)
11:66263154	rs374949402	L>P	A:544	(-45.64, -37.71, 15.91)
11:66263156		N>D	A:545	(-44.84, -32.73, 16.00)
11:66263163		V>D	A:547	(-40.41, -36.91, 14.65)
11:66263165	rs535853041	R>W	A:548	(-44.15, -33.54, 10.89)
11:66263166	rs200417388	R>Q	A:548	(-44.15, -33.54, 10.89)
11:66263196		T>I	A:558	(-27.87, -25.29, 2.96)
11:66263199		P>L	A:559	(-26.61, -28.60, 1.23)
11:66263211		N>S	A:563	(-25.51, -23.88, 6.85)
11:66264781	rs202040748	A>S	A:571	(-32.84, -29.10, 16.74)
11:66264784	rs200182592	R>W	A:572	(-37.52, -29.06, 15.89)
11:66264785		R>Q	A:572	(-37.52, -29.06, 15.89)
11:66264814	rs536447620	A>S	A:582	(-32.33, -45.70, 19.46)
11:66264820		E>K	A:584	(-35.05, -51.23, 18.98)
11:66264824	COSM3368513 COSM429658	G>V	A:585	(-38.38, -49.36, 15.62)
11:66264829		V>I	A:587	(-38.19, -44.32, 14.54)
11:66264856	rs202011847	D>N	A:596	(-49.62, -37.16, -6.32)
11:66264862		R>C	A:598	(-45.71, -35.48, -6.47)
11:66264863	rs201180715	R>H	A:598	(-45.71, -35.48, -6.47)
11:66264865	rs202163323	P>S	A:599	(-42.54, -38.17, -4.61)
11:66264874	rs74317854	R>W	A:602	(-46.56, -41.78, 5.30)
11:66264880	rs150300932	R>C	A:604	(-44.19, -45.26, 9.71)
11:66264881	rs202207843	R>H	A:604	(-44.19, -45.26, 9.71)
11:66264886	rs532334389	D>N	A:606	(-43.84, -47.56, 18.30)
11:66264889	rs137888856	R>C	A:607	(-48.38, -44.92, 21.01)
11:66264890	rs143553859	R>H	A:607	(-48.38, -44.92, 21.01)
11:66264894		S>R	A:608	(-45.05, -48.89, 22.58)
11:66264901	rs199640937	R>W	A:611	(-42.98, -44.74, 28.34)
11:66264902	rs569032157	R>Q	A:611	(-42.98, -44.74, 28.34)
11:66264915		K>N	A:615	(-36.22, -41.80, 28.89)
11:66264919	rs200574430	A>T	A:617	(-32.04, -41.12, 24.61)
11:66264925		E>Q	A:619	(-31.83, -39.63, 29.75)
11:66264928	rs201663539	R>C	A:620	(-28.79, -41.57, 27.10)
11:66264935		L>P	A:622	(-30.83, -33.77, 28.30)
11:66264938		R>Q	A:623	(-26.82, -37.29, 31.32)
11:66272108		A>V	A:635	(-15.43, -29.30, 21.72)
11:66272116	rs147163996	R>W	A:638	(-18.62, -27.58, 17.49)
11:66272117	rs34253106	R>Q	A:638	(-18.62, -27.58, 17.49)
11:66272120		A>V	A:639	(-18.74, -33.05, 18.43)
11:66272128	rs114407249	E>K	A:642	(-21.30, -29.90, 14.28)
11:66272135	rs147291241	Y>C	A:644	(-26.30, -36.46, 16.94)
11:66272140		T>A	A:646	(-24.54, -34.22, 9.87)
11:66272153		A>V	A:650	(-26.93, -42.36, 4.30)
11:66272155	rs142447712	P>T	A:651	(-28.33, -45.53, 4.30)
11:66272158	rs150831495	P>S	A:652	(-31.74, -46.51, 6.27)
11:66272186	rs540495338	T>M	A:661	(-39.78, -35.00, -0.78)
11:66272197	rs200243081 COSM3986374	R>C	A:665	(-45.19, -32.99, -0.56)
11:66272198	rs139251036	R>H	A:665	(-45.19, -32.99, -0.56)
11:66272200		K>E	A:666	(-42.31, -26.47, 0.09)
11:66272207	rs146568792	S>Y	A:668	(-45.32, -21.02, 3.00)
11:66272210	rs200822369	R>Q	A:669	(-44.46, -19.92, 8.40)
11:66272219	rs371234919	I>T	A:672	(-49.71, -12.45, 11.58)
11:66272236	rs199617262	R>C	A:678	(-55.08, 6.07, 14.97)
11:66272237	rs2305535	R>H	A:678	(-55.08, 6.07, 14.97)
11:66272245		G>S	A:681	(-56.58, 12.10, 22.90)
11:66276555		D>H	A:683	(-59.75, 9.46, 23.42)
11:66276558	rs140052578	V>M	A:684	(-57.34, 5.53, 22.80)
11:66276563	rs200762518	Q>H	A:685	(-59.82, 4.62, 18.83)
11:66276589	COSM429659	A>V	A:694	(-54.31, -6.16, 1.69)
11:66276594		L>I	A:696	(-50.54, -6.40, 6.08)
11:66276616	COSM3810140	R>H	A:703	(-48.47, 0.55, 11.44)
11:66276622		P>L	A:705	(-49.73, 8.70, 10.26)
11:66276624	rs199918678	E>Q	A:706	(-47.80, 10.99, 12.04)
11:66276636	rs201848080	E>K	A:710	(-39.40, 11.72, 8.57)
11:66276647		E>D	A:713	(-36.08, 10.40, 3.54)
11:66276648		I>F	A:714	(-34.67, 8.12, 8.04)
11:66276655		T>R	A:716	(-33.16, 6.40, 2.29)
11:66276672	rs371553288	D>N	A:722	(-23.83, 2.39, 5.42)
11:66276681		F>L	A:725	(-20.04, -1.08, 4.26)

3T6J.A | DPP3.

3T6J.A | DPP3

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
11:66254085	COSM147273	Q>H	A:145	(-31.98, 3.26, -10.78)
11:66262851	COSM1184498	R>W	A:490	(-12.04, -18.39, 32.00)
11:66264842	COSM3452094	P>L	A:591	(-39.40, -44.21, 0.81)
11:66272161	COSM3791828	E>K	A:653	(-31.99, -42.65, 6.53)
11:66272237	COSM3998543	R>H	A:678	(-55.08, 6.07, 14.97)
11:66276576	COSM4986815	E>K	A:690	(-58.78, -7.94, 5.40)