Assessment of Structural Intolerance and Durability
General Structure Information 4cca STXBP2 structure of human munc18-2 2.6Å AUTH Y.HACKMANN,S.C.GRAHAM,S.EHL,S.HOENING,K.LEHMBERG,M.ARICO,AUTH 2 D.J.OWEN,G.G.GRIFFITHSTITL SYNTAXIN BINDING MECHANISM AND DISEASE-CAUSING MUTATIONS INTITL 2 MUNC18-2REF PROC.NATL.ACAD.SCI.USA V. 110 E4482 2013REFN ISSN 0027-8424PMID 24194549DOI 10.1073/PNAS.1313474110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wtk STK11 structure of the heterotrimeric lkb1-stradalpha-mo25alpha complex 2.65Å AUTH E.ZEQIRAJ,B.M.FILIPPI,M.DEAK,D.R.ALESSI,D.M.F.VAN AALTENTITL STRUCTURE OF THE LKB1-STRAD-MO25 COMPLEX REVEALS ANTITL 2 ALLOSTERIC MECHANISM OF KINASE ACTIVATION.REF SCIENCE V. 326 1707 2009REFN ISSN 0036-8075PMID 19892943DOI 10.1126/SCIENCE.1178377 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2i6l MAPK6 crystal structure of human mitogen activated protein kinase 6 (mapk6) 2.25Å AUTH P.FILIPPAKOPOULOS,A.P.TURNBULL,P.SAVITSKY,AUTH 2 O.FEDOROV,G.BERRIDGE,S.DAS,J.ELKINS,AUTH 3 M.SOUNDARARAJAN,X.W.YANG,D.DOYLE,E.PAPAGRIGORIOU,AUTH 4 A.C.W.PIKE,G.BUNKONCZI,E.UGOCHUKWU,J.DEBRECZENI,AUTH 5 F.VON DELFT,A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,AUTH 6 S.KNAPPTITL CRYSTAL STRUCTURE OF THE HUMAN MITOGEN ACTIVATEDTITL 2 PROTEIN KINASE 6REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2f9m RAB11B 3d structure of active human rab11b gtpase 1.95Å AUTH S.M.SCAPIN,F.R.CARNEIRO,A.C.ALVES,F.J.MEDRANO,AUTH 2 B.G.GUIMARAES,N.I.ZANCHINTITL THE CRYSTAL STRUCTURE OF THE SMALL GTPASE RAB11BTITL 2 REVEALS CRITICAL DIFFERENCES RELATIVE TO THETITL 3 RAB11A ISOFORM.REF J.STRUCT.BIOL. V. 154 260 2006REFN ISSN 1047-8477PMID 16545962DOI 10.1016/J.JSB.2006.01.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2iag PTGIS crystal structure of human prostacyclin synthase 2.15Å AUTH C.-W.CHIANG,H.-C.YEH,L.-H.WANG,N.-L.CHANTITL CRYSTAL STRUCTURE OF THE HUMAN PROSTACYCLINTITL 2 SYNTHASEREF J.MOL.BIOL. V. 364 266 2006REFN ISSN 0022-2836PMID 17020766DOI 10.1016/J.JMB.2006.09.039 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3i8e DDB1 crystal structure of ddb1 in complex with the h-box motif of wdr42a 3.4Å AUTH T.LI,E.I.ROBERT,P.C.VAN BREUGEL,M.STRUBIN,N.ZHENGTITL A PROMISCUOUS ALPHA-HELICAL MOTIF ANCHORS VIRAL HIJACKERSTITL 2 AND SUBSTRATE RECEPTORS TO THE CUL4-DDB1 UBIQUITIN LIGASETITL 3 MACHINERY.REF NAT.STRUCT.MOL.BIOL. V. 17 105 2010REFN ISSN 1545-9993PMID 19966799DOI 10.1038/NSMB.1719 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2e0a PDK4 crystal structure of human pyruvate dehydrogenase kinase 4 in complex with amppnp 1.86Å AUTH M.KUKIMOTO-NIINO,A.TOKMAKOV,T.TERADA,N.OHBAYASHI,T.FUJIMOTO,AUTH 2 S.GOMI,I.SHIROMIZU,M.KAWAMOTO,T.MATSUSUE,M.SHIROUZU,AUTH 3 S.YOKOYAMATITL INHIBITOR-BOUND STRUCTURES OF HUMAN PYRUVATE DEHYDROGENASETITL 2 KINASE 4.REF ACTA CRYSTALLOGR.,SECT.D V. 67 763 2011REFN ISSN 0907-4449PMID 21904029DOI 10.1107/S090744491102405X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3vfq PARP14 human parp14 (artd8, bal2) – macro domains 1 and 2 in complex with adenosine-5-diphosphoribose 2.8Å AUTH A.H.FORST,T.KARLBERG,N.HERZOG,A.G.THORSELL,A.GROSS,AUTH 2 K.L.FEIJS,P.VERHEUGD,P.KURSULA,B.NIJMEIJER,E.KREMMER,AUTH 3 H.KLEINE,A.G.LADURNER,H.SCHULER,B.LUSCHERTITL RECOGNITION OF MONO-ADP-RIBOSYLATED ARTD10 SUBSTRATES BYTITL 2 ARTD8 MACRODOMAINS.REF STRUCTURE V. 21 462 2013REFN ISSN 0969-2126PMID 23473667DOI 10.1016/J.STR.2012.12.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1jvg UAP1 crystal structure of human agx2 complexed with udpgalnac 2.3Å AUTH C.PENEFF,P.FERRARI,V.CHARRIER,Y.TABURET,C.MONNIER,AUTH 2 V.ZAMBONI,J.WINTER,M.HARNOIS,F.FASSY,Y.BOURNETITL CRYSTAL STRUCTURES OF TWO HUMAN PYROPHOSPHORYLASETITL 2 ISOFORMS IN COMPLEXES WITH UDPGLC(GAL)NAC: ROLE OFTITL 3 THE ALTERNATIVELY SPLICED INSERT IN THE ENZYMETITL 4 OLIGOMERIC ASSEMBLY AND ACTIVE SITE ARCHITECTURE.REF EMBO J. V. 20 6191 2001REFN ISSN 0261-4189PMID […]
General Structure Information 2ic1 CDO1 crystal structure of human cysteine dioxygenase in complex with substrate cysteine 2.7Å AUTH S.YE,X.WU,L.WEI,D.TANG,P.SUN,M.BARTLAM,Z.RAOTITL AN INSIGHT INTO THE MECHANISM OF HUMAN CYSTEINETITL 2 DIOXYGENASE: KEY ROLES OF THE THIOETHER-BONDEDTITL 3 TYROSINE-CYSTEINE COFACTOR.REF J.BIOL.CHEM. V. 282 3391 2007REFN ISSN 0021-9258PMID 17135237DOI 10.1074/JBC.M609337200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]