Assessment of Structural Intolerance and Durability
General Structure Information 1wis SDK2 solution structure of the fifth fniii domain from human kiaa1514 protein -1.0Å AUTH T.SUETAKE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIFTH FNIII DOMAIN FROMTITL 2 HUMAN KIAA1514 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2hvz SRSF7 solution structure of the rrm domain of sr rich factor 9g8 -1.0Å AUTH Y.HARGOUS,G.M.HAUTBERGUE,A.M.TINTARU,L.SKRISOVSKA,AUTH 2 A.P.GOLOVANOV,J.STEVENIN,L.Y.LIAN,S.A.WILSON,AUTH 3 F.H.ALLAINTITL MOLECULAR BASIS OF RNA RECOGNITION AND TAP BINDINGTITL 2 BY THE SR PROTEINS SRP20 AND 9G8.REF EMBO J. V. 25 5126 2006REFN ISSN 0261-4189PMID 17036044DOI 10.1038/SJ.EMBOJ.7601385 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2vm8 DPYSL2 human crmp-2 crystallised in the presence of mg 1.9Å AUTH V.MAJAVA,N.LOYTYNOJA,W.Q.CHEN,G.LUBEC,P.KURSULATITL CRYSTAL AND SOLUTION STRUCTURE, STABILITY ANDTITL 2 POST- TRANSLATIONAL MODIFICATIONS OF COLLAPSINTITL 3 RESPONSE MEDIATOR PROTEIN 2.REF FEBS J. V. 275 4583 2008REFN ISSN 1742-464XPMID 18699782DOI 10.1111/J.1742-4658.2008.06601.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4e36 ERAP2 crystal structure of the human endoplasmic reticulum aminopeptidase 2 variant n392k 3.22Å AUTH I.EVNOUCHIDOU,J.BIRTLEY,S.SEREGIN,A.PAPAKYRIAKOU,E.ZERVOUDI,AUTH 2 M.SAMIOTAKI,G.PANAYOTOU,P.GIASTAS,O.PETRAKIS,D.GEORGIADIS,AUTH 3 A.AMALFITANO,E.SARIDAKIS,I.M.MAVRIDIS,E.STRATIKOSTITL A COMMON SINGLE NUCLEOTIDE POLYMORPHISM IN ENDOPLASMICTITL 2 RETICULUM AMINOPEPTIDASE 2 INDUCES A SPECIFICITY SWITCH THATTITL 3 LEADS TO ALTERED ANTIGEN PROCESSING.REF J.IMMUNOL. V. 189 2383 2012REFN ISSN 0022-1767PMID 22837489DOI 10.4049/JIMMUNOL.1200918 Variant […]
General Structure Information 4kbs GLTPD1 crystal structure of human ceramide-1-phosphate transfer protein (cptp) in complex with 12:0 phosphatidic acid (12:0 pa) 1.9Å AUTH D.K.SIMANSHU,R.K.KAMLEKAR,D.S.WIJESINGHE,X.ZOU,X.ZHAI,AUTH 2 S.K.MISHRA,J.G.MOLOTKOVSKY,L.MALININA,E.H.HINCHCLIFFE,AUTH 3 C.E.CHALFANT,R.E.BROWN,D.J.PATELTITL NON-VESICULAR TRAFFICKING BY A CERAMIDE-1-PHOSPHATE TRANSFERTITL 2 PROTEIN REGULATES EICOSANOIDS.REF NATURE V. 500 463 2013REFN ISSN 0028-0836PMID 23863933DOI 10.1038/NATURE12332 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4b87 DCLRE1A crystal structure of human dna cross-link repair 1a 2.16Å AUTH C.K.ALLERSTON,G.BERRIDGE,E.P.CARPENTER,G.KOCHAN,T.KROJER,AUTH 2 P.MAHAJAN,M.VOLLMAR,W.W.YUE,C.H.ARROWSMITH,A.EDWARDS,AUTH 3 C.BOUNTRA,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURE OF HUMAN DNA CROSS-LINK REPAIR 1AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3puf RNASEH2B crystal structure of human rnase h2 complex 3.1Å AUTH M.FIGIEL,H.CHON,S.M.CERRITELLI,M.CYBULSKA,R.J.CROUCH,AUTH 2 M.NOWOTNYTITL THE STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF HUMANTITL 2 RNASE H2 COMPLEX REVEALS THE MOLECULAR BASIS FOR SUBSTRATETITL 3 RECOGNITION AND AICARDI-GOUTIERES SYNDROME DEFECTS.REF J.BIOL.CHEM. V. 286 10540 2011REFN ISSN 0021-9258PMID 21177858DOI 10.1074/JBC.M110.181974 Variant Set Distributions Pathogenic Proximity Analysis […]
General Structure Information 3d6t LRRK2 structure of the roc domain from the parkinsons disease-associated leucine-rich repeat kinase 2 reveals a dimeric gtpase 2.43Å AUTH J.DENG,P.A.LEWIS,E.GREGGIO,E.SLUCH,A.BEILINA,M.R.COOKSONTITL STRUCTURE OF THE ROC DOMAIN FROM THE PARKINSONSTITL 2 DISEASE-ASSOCIATED LEUCINE-RICH REPEAT KINASE 2 REVEALS ATITL 3 DIMERIC GTPASEREF PROC.NATL.ACAD.SCI.USA V. 105 1499 2008REFN ISSN 0027-8424PMID 18230735DOI 10.1073/PNAS.0709098105 Variant Set […]
General Structure Information 3bdl SND1 crystal structure of a truncated human tudor-sn 1.9Å AUTH C.L.LI,W.Z.YANG,Y.P.CHEN,H.S.YUANTITL STRUCTURAL AND FUNCTIONAL INSIGHTS INTO HUMANTITL 2 TUDOR-SN, A KEY COMPONENT LINKING RNA INTERFERENCETITL 3 AND EDITING.REF NUCLEIC ACIDS RES. V. 36 3579 2008REFN ISSN 0305-1048PMID 18453631DOI 10.1093/NAR/GKN236 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4mtl METTL21C human methyltransferase-like protein 21c 1.65Å AUTH B.S.HONG,W.TEMPEL,A.DONG,Y.LI,C.H.ARROWSMITH,C.BOUNTRA,AUTH 2 A.M.EDWARDS,P.J.BROWNTITL HUMAN METHYLTRANSFERASE-LIKE PROTEIN 21CREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants