Assessment of Structural Intolerance and Durability
General Structure Information 2coc FGD3 solution structure of the c-terminal ph domain of fyve, rhogef and ph domain containing protein 3 (fgd3) from human -1.0Å AUTH H.LI,T.TOMIZAWA,N.TOCHIO,Y.MUTO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C-TERMINAL PH DOMAIN OFTITL 2 FYVE, RHOGEF AND PH DOMAIN CONTAINING PROTEIN 3TITL 3 (FGD3) FROM HUMANREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 3bpt HIBCH crystal structure of human beta-hydroxyisobutyryl-coa hydrolase in complex with quercetin 1.5Å AUTH E.S.PILKA,C.PHILLIPS,O.N.F.KING,K.GUO,F.VON DELFT,AUTH 2 A.C.W.PIKE,C.H.ARROWSMITH,J.WEIGELT,A.M.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN BETA-HYDROXYISOBUTYRYL-COATITL 2 HYDROLASE IN COMPLEX WITH QUERCETIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2rfj BRDT crystal structure of the bromo domain 1 in human bromodomain containing protein, testis specific (brdt) 2.05Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1ekg FXN mature human frataxin 1.8Å AUTH S.DHE-PAGANON,R.SHIGETA,Y.I.CHI,M.RISTOW,AUTH 2 S.E.SHOELSONTITL CRYSTAL STRUCTURE OF HUMAN FRATAXIN.REF J.BIOL.CHEM. V. 275 30753 2000REFN ISSN 0021-9258PMID 10900192DOI 10.1074/JBC.C000407200 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2yz8 OBSCN crystal structure of the 32th ig-like domain of human obscurin (kiaa1556) 2.0Å AUTH S.SAIJO,N.OHSAWA,A.NISHINO,S.KISHISHITA,L.CHEN,Z.Q.FU,AUTH 2 J.CHRZAS,B.C.WANG,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE 32TH IG-LIKE DOMAIN OF HUMANTITL 2 OBSCURIN (KIAA1556)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2yrb RPGRIP1L solution structure of the first c2 domain from human kiaa1005 protein -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST C2 DOMAIN FROMTITL 2 HUMAN KIAA1005 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3hzj RABGAP1L crystal structure of the rabgap domain of the rabgap1l protein 2.3Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,N.ZHONG,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RABGAP DOMAIN OF THETITL 2 RABGAP1L PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3nbq UPP1 human uridine phosphorylase 1 (hupp1) with 5-fluorouracil 2.3Å AUTH T.P.ROOSILD,S.CASTRONOVOTITL ACTIVE SITE CONFORMATIONAL DYNAMICS IN HUMAN URIDINETITL 2 PHOSPHORYLASE 1.REF PLOS ONE V. 5 E1274 2010REFN ESSN 1932-6203PMID 20856879DOI 10.1371/JOURNAL.PONE.0012741 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3qbv ITSN1 structure of designed orthogonal interaction between cdc42 and nucleotide exchange domains of intersectin 2.65Å AUTH G.T.KAPP,S.LIU,A.STEIN,D.T.WONG,A.REMENYI,B.J.YEH,AUTH 2 J.S.FRASER,J.TAUNTON,W.A.LIM,T.KORTEMMETITL CONTROL OF PROTEIN SIGNALING USING A COMPUTATIONALLYTITL 2 DESIGNED GTPASE/GEF ORTHOGONAL PAIR.REF PROC.NATL.ACAD.SCI.USA V. 109 5277 2012REFN ISSN 0027-8424PMID 22403064DOI 10.1073/PNAS.1114487109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4gn1 RAPH1 crystal structure of the ra and ph domains of lamellipodin 2.4Å AUTH Y.C.CHANG,H.ZHANG,M.L.BRENNAN,J.WUTITL CRYSTAL STRUCTURE OF LAMELLIPODIN IMPLICATES DIVERSETITL 2 FUNCTIONS IN ACTIN POLYMERIZATION AND RAS SIGNALING.REF PROTEIN CELL V. 4 211 2013REFN ISSN 1674-800XPMID 23483482DOI 10.1007/S13238-013-2082-5 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]