General Structure Information
| PDB ID | 4e36 |
| HGNC Gene Label(s) | ERAP2 |
| Structure Name | crystal structure of the human endoplasmic reticulum aminopeptidase 2 variant n392k |
| Resolution | 3.22Å |
| Reference | AUTH I.EVNOUCHIDOU,J.BIRTLEY,S.SEREGIN,A.PAPAKYRIAKOU,E.ZERVOUDI,AUTH 2 M.SAMIOTAKI,G.PANAYOTOU,P.GIASTAS,O.PETRAKIS,D.GEORGIADIS,AUTH 3 A.AMALFITANO,E.SARIDAKIS,I.M.MAVRIDIS,E.STRATIKOSTITL A COMMON SINGLE NUCLEOTIDE POLYMORPHISM IN ENDOPLASMICTITL 2 RETICULUM AMINOPEPTIDASE 2 INDUCES A SPECIFICITY SWITCH THATTITL 3 LEADS TO ALTERED ANTIGEN PROCESSING.REF J.IMMUNOL. V. 189 2383 2012REFN ISSN 0022-1767PMID 22837489DOI 10.4049/JIMMUNOL.1200918 |
Variant Set Distributions
ExAC Variants
COSMIC
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 227 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 31.0 |
| K Statistic | 0.214 |
| p-value | 0.482 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 5:96215564 | G>R | A:59 | (-19.52, 1.87, 5.93) | |
| 5:96215571 | rs565149554 COSM738866 |
R>Q | A:61 | (-19.92, 4.29, -1.50) |
| 5:96215574 | rs199924315 | F>Y | A:62 | (-13.28, 3.82, -1.29) |
| 5:96215591 | R>W | A:68 | (-0.84, 2.95, -8.51) | |
| 5:96215593 | rs202185665 | R>S | A:68 | (-0.84, 2.95, -8.51) |
| 5:96215594 | L>F | A:69 | (-3.42, 7.15, -6.50) | |
| 5:96215619 | rs562967580 | H>L | A:77 | (2.20, 23.87, -2.46) |
| 5:96215625 | D>V | A:79 | (0.97, 24.55, 2.99) | |
| 5:96215628 | L>R | A:80 | (3.10, 20.83, 6.41) | |
| 5:96215638 | H>Q | A:83 | (2.39, 21.25, 17.85) | |
| 5:96215643 | rs190219466 | N>S | A:85 | (4.72, 17.12, 22.58) |
| 5:96215670 | COSM1251411 | S>F | A:94 | (-2.25, 21.35, 9.64) |
| 5:96215675 | K>E | A:96 | (-2.97, 24.51, 2.33) | |
| 5:96215678 | I>V | A:97 | (-3.08, 19.96, -0.75) | |
| 5:96215697 | rs376750913 | N>T | A:103 | (-10.56, 14.61, -16.02) |
| 5:96215718 | rs571158626 | L>S | A:110 | (-5.37, 11.06, -0.55) |
| 5:96215725 | rs139129312 | S>R | A:112 | (-3.74, 7.87, 5.21) |
| 5:96215728 | K>N | A:113 | (-1.11, 4.42, 7.87) | |
| 5:96215733 | L>P | A:115 | (-3.39, 10.00, 10.27) | |
| 5:96215742 | T>M | A:118 | (-10.04, 16.53, 12.93) | |
| 5:96215747 | rs145045143 | A>P | A:120 | (-12.29, 18.53, 5.74) |
| 5:96215756 | COSM1487061 | Q>K | A:123 | (-10.87, 26.84, 0.36) |
| 5:96215780 | M>V | A:131 | (-16.04, 28.94, -3.62) | |
| 5:96215799 | rs202144889 | L>R | A:137 | (-14.93, 17.60, 2.21) |
| 5:96215802 | K>R | A:138 | (-18.11, 12.89, 3.41) | |
| 5:96215811 | S>I | A:141 | (-11.13, 5.26, 5.53) | |
| 5:96215822 | H>Y | A:145 | (-5.62, -0.40, -0.80) | |
| 5:96215823 | rs554491944 COSM3373984 COSM3373985 |
H>R | A:145 | (-5.62, -0.40, -0.80) |
| 5:96215825 | rs143635500 | E>K | A:146 | (-2.36, 2.57, 3.18) |
| 5:96215830 | rs193185786 | Q>H | A:147 | (-6.48, 4.72, -0.19) |
| 5:96215859 | T>M | A:157 | (-13.90, 21.80, -12.99) | |
| 5:96215861 | P>S | A:158 | (-11.75, 20.45, -15.69) | |
| 5:96215862 | P>R | A:158 | (-11.75, 20.45, -15.69) | |
| 5:96215864 | H>Y | A:159 | (-8.31, 22.40, -17.07) | |
| 5:96215891 | F>V | A:168 | (-3.27, 16.07, 10.35) | |
| 5:96215913 | rs140628405 | G>A | A:175 | (9.43, 2.88, 15.17) |
| 5:96215922 | rs564736676 COSM1671763 COSM1671764 |
G>A | A:178 | (7.78, 8.13, 10.08) |
| 5:96215933 | S>G | A:182 | (14.45, 8.79, 19.37) | |
| 5:96215945 | T>P | A:186 | (23.94, 11.90, 28.06) | |
| 5:96219498 | I>T | A:193 | (12.90, 12.29, 23.46) | |
| 5:96219504 | rs145672042 | A>V | A:195 | (11.51, 13.96, 16.42) |
| 5:96219534 | rs73150323 | R>H | A:205 | (1.15, 6.68, 3.17) |
| 5:96219538 | M>I | A:206 | (2.30, 7.00, 8.85) | |
| 5:96219589 | K>N | A:223 | (4.76, 26.36, 9.03) | |
| 5:96219591 | COSM1671767 COSM1671768 |
I>T | A:224 | (7.83, 23.13, 12.92) |
| 5:96219592 | I>M | A:224 | (7.83, 23.13, 12.92) | |
| 5:96219597 | R>I | A:226 | (10.75, 25.36, 18.67) | |
| 5:96219599 | rs368480890 | E>K | A:227 | (9.67, 23.21, 23.95) |
| 5:96219601 | E>D | A:227 | (9.67, 23.21, 23.95) | |
| 5:96219609 | rs372040296 | H>R | A:230 | (13.45, 21.20, 21.60) |
| 5:96219621 | S>F | A:234 | (13.63, 20.64, 7.35) | |
| 5:96219624 | N>S | A:235 | (14.05, 19.51, 3.77) | |
| 5:96222360 | rs80193285 | V>A | A:239 | (12.78, 32.03, 6.87) |
| 5:96222383 | G>S | A:247 | (6.95, 30.60, 24.54) | |
| 5:96222400 | H>Q | A:252 | (8.27, 29.85, 9.33) | |
| 5:96222408 | T>S | A:255 | (9.45, 26.65, -0.39) | |
| 5:96222413 | V>I | A:257 | (12.21, 22.15, -4.88) | |
| 5:96222414 | V>A | A:257 | (12.21, 22.15, -4.88) | |
| 5:96222417 | K>T | A:258 | (8.54, 20.71, -7.51) | |
| 5:96222419 | COSM1671769 COSM1671770 |
M>V | A:259 | (10.12, 17.09, -3.34) |
| 5:96222422 | rs201788129 | S>G | A:260 | (8.99, 13.38, -3.95) |
| 5:96222423 | S>I | A:260 | (8.99, 13.38, -3.95) | |
| 5:96222428 | Y>H | A:262 | (10.89, 9.65, -1.24) | |
| 5:96222429 | Y>F | A:262 | (10.89, 9.65, -1.24) | |
| 5:96222437 | A>T | A:265 | (11.93, 16.10, 6.45) | |
| 5:96222449 | COSM1684032 COSM1684033 |
C>R | A:269 | (16.42, 18.32, 18.32) |
| 5:96222471 | G>D | A:276 | (30.41, 24.69, 6.36) | |
| 5:96222479 | rs138644698 | S>A | A:279 | (33.36, 26.10, -3.08) |
| 5:96224895 | I>L | A:286 | (27.57, 17.56, 10.82) | |
| 5:96224897 | I>M | A:286 | (27.57, 17.56, 10.82) | |
| 5:96224904 | rs117041256 | S>A | A:289 | (24.72, 14.25, 20.25) |
| 5:96224916 | R>W | A:293 | (30.55, 19.40, 18.56) | |
| 5:96224917 | R>Q | A:293 | (30.55, 19.40, 18.56) | |
| 5:96224923 | rs113033185 | Q>L | A:295 | (32.23, 11.50, 16.97) |
| 5:96224929 | H>R | A:297 | (35.39, 17.36, 13.32) | |
| 5:96224931 | rs369289834 | Y>H | A:298 | (35.93, 12.09, 7.84) |
| 5:96224932 | rs189272659 | Y>S | A:298 | (35.93, 12.09, 7.84) |
| 5:96224946 | S>P | A:303 | (30.80, 16.33, 3.09) | |
| 5:96224979 | rs148457030 | F>I | A:314 | (26.94, 14.82, -11.37) |
| 5:96224985 | I>V | A:316 | (24.30, 19.79, -11.83) | |
| 5:96228007 | L>F | A:325 | (24.69, 15.60, 7.41) | |
| 5:96228014 | rs142595885 | I>V | A:328 | (19.42, 9.57, 13.98) |
| 5:96228029 | rs546243037 | P>S | A:333 | (18.12, 2.85, 7.87) |
| 5:96228039 | M>R | A:336 | (17.16, 8.76, 3.83) | |
| 5:96228043 | E>D | A:337 | (18.00, 9.95, 0.19) | |
| 5:96228045 | N>S | A:338 | (16.03, 13.05, 3.42) | |
| 5:96228048 | W>L | A:339 | (16.59, 17.53, -2.24) | |
| 5:96228050 | G>C | A:340 | (18.95, 18.56, 3.08) | |
| 5:96228063 | Y>C | A:344 | (23.65, 9.77, 7.92) | |
| 5:96228072 | rs75263594 | T>M | A:347 | (27.48, 3.71, 12.56) |
| 5:96228096 | rs375951913 | T>I | A:355 | (37.24, 3.84, 18.48) |
| 5:96228110 | rs200808443 COSM175636 |
D>N | A:360 | (35.10, 2.08, 10.42) |
| 5:96228117 | L>P | A:362 | (36.10, 3.15, 3.77) | |
| 5:96228131 | V>L | A:367 | (27.45, 6.33, 3.58) | |
| 5:96228145 | E>D | A:371 | (23.18, 9.32, 0.94) | |
| 5:96228150 | A>E | A:373 | (24.56, 10.95, -4.84) | |
| 5:96230951 | W>S | A:376 | (23.10, 15.52, -7.63) | |
| 5:96230960 | N>T | A:379 | (16.57, 13.74, -4.65) | |
| 5:96230969 | COSM3662027 | T>K | A:382 | (12.59, 10.73, -9.18) |
| 5:96230975 | E>A | A:384 | (8.07, 7.21, -13.30) | |
| 5:96230990 | I>T | A:389 | (14.49, 1.52, -7.14) | |
| 5:96230991 | I>M | A:389 | (14.49, 1.52, -7.14) | |
| 5:96230993 | W>L | A:390 | (18.13, 0.49, -11.78) | |
| 5:96231000 | rs2549782 | K>N | A:392 | (17.44, 5.76, -6.25) |
| 5:96231010 | A>S | A:396 | (24.38, 5.42, -5.93) | |
| 5:96231017 | rs144292939 | Y>C | A:398 | (29.19, 3.62, -10.32) |
| 5:96231019 | rs560394500 | M>L | A:399 | (28.79, 7.69, -8.14) |
| 5:96231029 | I>T | A:402 | (33.50, 7.40, -9.25) | |
| 5:96231031 | A>T | A:403 | (33.90, 9.82, -5.66) | |
| 5:96231032 | A>V | A:403 | (33.90, 9.82, -5.66) | |
| 5:96231043 | rs138646616 | T>A | A:407 | (38.03, 12.28, -3.08) |
| 5:96232093 | rs143365902 | N>I | A:419 | (33.85, -7.49, -2.88) |
| 5:96232099 | rs148344927 | C>Y | A:421 | (29.94, -7.68, -7.43) |
| 5:96232118 | rs150559976 | K>N | A:427 | (21.49, -13.48, -3.77) |
| 5:96232122 | S>A | A:429 | (23.63, -17.95, -8.60) | |
| 5:96232137 | R>C | A:434 | (15.14, -9.20, -8.69) | |
| 5:96232138 | COSM1620684 | R>H | A:434 | (15.14, -9.20, -8.69) |
| 5:96232159 | E>G | A:441 | (1.84, -3.28, -6.25) | |
| 5:96232164 | rs200759803 | P>A | A:443 | (3.87, -1.88, 0.67) |
| 5:96232165 | P>L | A:443 | (3.87, -1.88, 0.67) | |
| 5:96232168 | T>I | A:444 | (5.99, -5.53, 1.26) | |
| 5:96232194 | rs373007770 | V>I | A:453 | (19.62, -6.74, -7.27) |
| 5:96232198 | rs147381806 | S>F | A:454 | (18.70, -2.92, -6.95) |
| 5:96232437 | rs377445279 | G>V | A:458 | (23.48, -2.07, -10.73) |
| 5:96232439 | A>T | A:459 | (26.43, -0.93, -9.78) | |
| 5:96232455 | M>T | A:464 | (29.64, -3.65, -17.59) | |
| 5:96232457 | L>V | A:465 | (27.72, 0.28, -19.64) | |
| 5:96232475 | E>K | A:471 | (34.47, 8.28, -17.60) | |
| 5:96232503 | Q>P | A:480 | (23.17, 14.36, -21.43) | |
| 5:96232506 | Y>S | A:481 | (19.44, 10.86, -16.56) | |
| 5:96232511 | rs373479710 | K>Q | A:483 | (21.19, 18.72, -17.11) |
| 5:96232515 | K>T | A:484 | (15.83, 15.28, -20.27) | |
| 5:96232521 | rs201986447 COSM1581173 |
S>N | A:486 | (15.82, 18.17, -13.53) |
| 5:96232532 | A>T | A:490 | (12.48, 8.61, -14.93) | |
| 5:96232533 | rs376575375 | A>D | A:490 | (12.48, 8.61, -14.93) |
| 5:96232537 | K>N | A:491 | (10.62, 5.56, -17.93) | |
| 5:96232538 | N>Y | A:492 | (14.44, 1.70, -17.11) | |
| 5:96232545 | D>G | A:494 | (14.09, 7.58, -20.00) | |
| 5:96232551 | rs144069129 | W>L | A:496 | (19.67, 2.10, -20.24) |
| 5:96232554 | S>N | A:497 | (18.13, 6.67, -24.11) | |
| 5:96237223 | G>E | A:529 | (25.79, 7.07, -39.17) | |
| 5:96237234 | E>K | A:533 | (23.21, -1.34, -29.78) | |
| 5:96237236 | E>D | A:533 | (23.21, -1.34, -29.78) | |
| 5:96237237 | V>I | A:534 | (23.52, 0.28, -25.95) | |
| 5:96237250 | M>R | A:538 | (21.88, -2.74, -20.58) | |
| 5:96237251 | rs143505160 | M>I | A:538 | (21.88, -2.74, -20.58) |
| 5:96237277 | I>T | A:547 | (25.13, -14.30, -14.09) | |
| 5:96237307 | rs200977498 | C>Y | A:557 | (43.99, -20.12, -33.14) |
| 5:96237331 | R>H | A:565 | (20.68, -19.28, -15.57) | |
| 5:96237378 | Q>E | A:581 | (17.84, -22.86, -16.58) | |
| 5:96237384 | R>G | A:583 | (15.65, -18.79, -21.81) | |
| 5:96238006 | S>T | A:593 | (44.53, -11.25, -22.69) | |
| 5:96238010 | rs376810617 | T>M | A:594 | (47.10, -13.09, -24.43) |
| 5:96239098 | rs371847009 | E>K | A:616 | (50.37, -15.32, -32.32) |
| 5:96239107 | S>R | A:619 | (49.90, -19.91, -23.51) | |
| 5:96239124 | N>K | A:624 | (36.61, -10.26, -17.45) | |
| 5:96239128 | rs578057926 | D>N | A:626 | (40.32, -5.70, -14.29) |
| 5:96239137 | G>C | A:629 | (32.18, -8.01, -15.79) | |
| 5:96239147 | I>N | A:632 | (31.26, -16.42, -14.87) | |
| 5:96239149 | rs545472330 COSM1071480 |
V>I | A:633 | (35.02, -17.35, -17.29) |
| 5:96239153 | rs145822095 | H>R | A:634 | (34.64, -23.13, -17.45) |
| 5:96239161 | G>S | A:637 | (40.69, -27.66, -21.04) | |
| 5:96239194 | N>H | A:648 | (52.38, -21.20, -9.08) | |
| 5:96239197 | Q>K | A:649 | (55.47, -20.20, -12.96) | |
| 5:96239206 | T>P | A:652 | (53.24, -10.61, -11.79) | |
| 5:96239207 | T>I | A:652 | (53.24, -10.61, -11.79) | |
| 5:96239233 | G>S | A:661 | (38.79, -13.21, -10.16) | |
| 5:96239234 | rs61731306 | G>V | A:661 | (38.79, -13.21, -10.16) |
| 5:96239258 | rs17408150 | L>Q | A:669 | (33.20, -23.02, -11.41) |
| 5:96239261 | V>A | A:670 | (33.71, -25.94, -7.34) | |
| 5:96244696 | rs143471576 | D>H | A:682 | (45.81, -26.56, -5.98) |
| 5:96244697 | rs200317861 | D>V | A:682 | (45.81, -26.56, -5.98) |
| 5:96244718 | rs552095171 | H>R | A:689 | (54.23, -16.48, -3.90) |
| 5:96244724 | T>I | A:691 | (51.57, -8.95, -2.40) | |
| 5:96244733 | rs367662467 | P>L | A:694 | (43.23, -7.77, -2.59) |
| 5:96244735 | rs201095797 | A>T | A:695 | (43.80, -11.66, -3.35) |
| 5:96244744 | rs150106511 | E>K | A:698 | (39.33, -13.54, -2.63) |
| 5:96244756 | Y>H | A:702 | (36.65, -18.44, -0.95) | |
| 5:96244765 | S>P | A:705 | (34.58, -20.61, 4.50) | |
| 5:96244778 | rs142470147 | M>T | A:709 | (31.21, -25.08, 6.47) |
| 5:96244781 | M>T | A:710 | (33.81, -28.03, 8.57) | |
| 5:96244802 | rs568167337 | D>G | A:717 | (38.42, -34.19, 10.47) |
| 5:96244805 | rs373745801 | I>T | A:718 | (38.17, -31.28, 7.79) |
| 5:96245284 | rs578206996 | R>C | A:724 | (46.83, -28.61, 11.64) |
| 5:96245291 | L>H | A:726 | (45.15, -21.63, 7.67) | |
| 5:96245297 | Q>R | A:728 | (51.39, -22.98, 8.56) | |
| 5:96245321 | rs371004093 | R>K | A:736 | (55.15, -10.44, 7.53) |
| 5:96245342 | rs138669960 | G>D | A:743 | (49.66, 1.89, 7.11) |
| 5:96245365 | rs150892504 | R>C | A:751 | (47.40, -5.19, 10.80) |
| 5:96245366 | rs371569095 | R>H | A:751 | (47.40, -5.19, 10.80) |
| 5:96245369 | rs376256256 | S>L | A:752 | (42.79, -7.07, 11.07) |
| 5:96245372 | A>V | A:753 | (42.53, -10.22, 9.00) | |
| 5:96245374 | L>F | A:754 | (45.93, -12.03, 9.10) | |
| 5:96245402 | H>R | A:763 | (48.94, -18.61, 17.14) | |
| 5:96245405 | A>D | A:764 | (49.03, -19.01, 21.36) | |
| 5:96245407 | P>S | A:765 | (50.90, -16.63, 20.31) | |
| 5:96245425 | A>T | A:771 | (44.95, -11.19, 26.54) | |
| 5:96245438 | S>F | A:775 | (44.01, -7.24, 31.38) | |
| 5:96245455 | S>G | A:781 | (40.22, 1.86, 33.85) | |
| 5:96248367 | V>G | A:794 | (41.22, -7.43, 22.41) | |
| 5:96248391 | T>I | A:802 | (32.62, -14.21, 33.10) | |
| 5:96248397 | G>E | A:804 | (35.09, -9.48, 30.86) | |
| 5:96248408 | L>V | A:808 | (33.00, -5.62, 27.56) | |
| 5:96248429 | rs148708472 | S>A | A:815 | (30.20, 4.24, 25.21) |
| 5:96248440 | rs200211238 | S>R | A:818 | (29.02, 4.04, 17.81) |
| 5:96248448 | Q>R | A:821 | (28.74, 0.73, 21.36) | |
| 5:96248472 | S>L | A:829 | (28.93, -12.60, 20.08) | |
| 5:96248475 | rs536000248 | T>M | A:830 | (32.70, -14.24, 21.02) |
| 5:96248483 | H>Y | A:833 | (29.06, -19.24, 28.52) | |
| 5:96248492 | rs374962061 | K>E | A:836 | (26.43, -14.81, 28.84) |
| 5:96248499 | rs151262056 | L>P | A:838 | (19.87, -15.55, 25.60) |
| 5:96249024 | rs374643424 | L>F | A:840 | (23.15, -10.32, 24.10) |
| 5:96249026 | I>T | A:841 | (19.13, -12.24, 21.75) | |
| 5:96249044 | rs570709513 | G>E | A:847 | (15.98, -1.71, 23.76) |
| 5:96249048 | K>N | A:848 | (15.49, -0.31, 27.52) | |
| 5:96249052 | rs377627713 | I>L | A:850 | (21.10, -3.49, 23.00) |
| 5:96249073 | A>T | A:857 | (23.16, -7.88, 13.39) | |
| 5:96249076 | L>V | A:858 | (23.11, -9.48, 17.58) | |
| 5:96249077 | L>P | A:858 | (23.11, -9.48, 17.58) | |
| 5:96249086 | rs145600606 | A>V | A:861 | (26.42, -13.09, 14.96) |
| 5:96249089 | I>T | A:862 | (24.82, -15.31, 17.78) | |
| 5:96249097 | rs201533372 | R>C | A:865 | (30.68, -17.90, 16.55) |
| 5:96249098 | R>H | A:865 | (30.68, -17.90, 16.55) | |
| 5:96249107 | G>A | A:868 | (24.36, -20.21, 18.37) | |
| 5:96249122 | W>L | A:873 | (15.76, -21.63, 13.55) | |
| 5:96249129 | COSM1071483 | F>L | A:875 | (14.61, -15.63, 19.63) |
| 5:96249130 | V>L | A:876 | (13.61, -16.48, 15.17) | |
| 5:96249133 | R>G | A:877 | (12.05, -21.75, 15.36) | |
| 5:96249142 | W>R | A:880 | (7.88, -14.09, 12.60) | |
| 5:96251399 | L>V | A:889 | (6.94, -8.58, 6.62) | |
| 5:96251405 | S>P | A:891 | (12.15, -5.35, 6.85) | |
| 5:96251414 | I>L | A:894 | (12.42, -9.34, 9.17) | |
| 5:96251418 | COSM4137903 | R>K | A:895 | (15.11, -8.80, 3.91) |
| 5:96251435 | T>A | A:901 | (19.14, -17.37, 11.39) | |
| 5:96251436 | T>I | A:901 | (19.14, -17.37, 11.39) | |
| 5:96251460 | rs200664779 | D>V | A:909 | (18.08, -32.09, 9.39) |
| 5:96251469 | rs142659150 | Q>R | A:912 | (12.38, -29.90, 6.52) |
| 5:96251471 | E>K | A:913 | (13.88, -27.47, 11.25) | |
| 5:96253173 | L>P | A:916 | (7.76, -26.45, 8.55) | |
| 5:96253184 | S>P | A:920 | (4.04, -21.33, 9.43) | |
| 5:96253185 | COSM1071485 | S>F | A:920 | (4.04, -21.33, 9.43) |
| 5:96253198 | Q>H | A:924 | (1.34, -11.20, 8.05) | |
| 5:96253211 | rs144903049 | D>Y | A:929 | (10.93, -13.26, -2.32) |
| 5:96253223 | T>P | A:933 | (16.56, -17.39, -1.35) | |
| 5:96253227 | rs184018698 | V>A | A:934 | (16.61, -19.58, 2.57) |
| 5:96253236 | rs553483477 | T>M | A:937 | (20.98, -21.41, 0.09) |
| 5:96253242 | T>N | A:939 | (19.90, -26.83, -1.12) | |
| 5:96253267 | K>N | A:947 | (29.54, -33.44, -5.08) | |
| 5:96253270 | N>K | A:948 | (32.97, -30.86, -3.06) | |
| 5:96253275 | COSM483185 | P>L | A:950 | (35.04, -35.75, 0.08) |
| 5:96253281 | rs73152140 | L>P | A:952 | (38.34, -30.78, 1.89) |
| 5:96253286 | T>S | A:954 | (41.83, -35.98, 0.47) | |
| 5:96253296 | M>T | A:957 | (45.50, -35.82, 4.99) |
[+] COSMIC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 5:96215643 | COSM3715282 | N>S | A:85 | (4.72, 17.12, 22.58) |
| 5:96215716 | COSM1717538 | I>M | A:109 | (-8.22, 9.46, -3.80) |
| 5:96219591 | COSM1671767 | I>T | A:224 | (7.83, 23.13, 12.92) |
| 5:96230969 | COSM3662027 | T>I | A:382 | (12.59, 10.73, -9.18) |
| 5:96232138 | COSM1620684 | R>H | A:434 | (15.14, -9.20, -8.69) |
| 5:96232463 | COSM1695978 | D>N | A:467 | (34.45, -0.81, -19.83) |