Assessment of Structural Intolerance and Durability
General Structure Information 1fik PFN1 human platelet profilin i crystallized in low salt 2.3Å AUTH A.A.FEDOROV,T.D.POLLARD,S.C.ALMOTITL CRYSTAL STRUCTURE OF HUMAN PROFILIN AT 2.0TITL 2 ANGSTROMS RESOLUTIONREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2hb8 VDR crystal structure of vdr lbd in complex with 2alpha-methyl calcitriol 2.0Å AUTH S.HOURAI,T.FUJISHIMA,A.KITTAKA,Y.SUHARA,H.TAKAYAMA,AUTH 2 N.ROCHEL,D.MORASTITL PROBING A WATER CHANNEL NEAR THE A-RING OFTITL 2 RECEPTOR-BOUND 1ALPHA,25-DIHYDROXYVITAMIN D3 WITHTITL 3 SELECTED 2ALPHA-SUBSTITUTED ANALOGUESREF J.MED.CHEM. V. 49 5199 2006REFN ISSN 0022-2623PMID 16913708DOI 10.1021/JM0604070 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4dy0 SERPINE2 crystal structure of native protease nexin-1 with heparin 2.35Å AUTH W.LI,J.A.HUNTINGTONTITL CRYSTAL STRUCTURES OF PROTEASE NEXIN-1 IN COMPLEX WITHTITL 2 HEPARIN AND THROMBIN SUGGEST A 2-STEP RECOGNITION MECHANISM.REF BLOOD V. 120 459 2012REFN ISSN 0006-4971PMID 22618708DOI 10.1182/BLOOD-2012-03-415869 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1ux6 THBS1 structure of a thrombospondin c-terminal fragment reveals a novel calcium core in the type 3 repeats 1.9Å AUTH M.KVANSAKUL,J.C.ADAMS,E.HOHENESTERTITL STRUCTURE OF A THROMBOSPONDIN C-TERMINAL FRAGMENTTITL 2 REVEALS A NOVEL CALCIUM CORE IN THE TYPE 3 REPEATSREF EMBO J. V. 23 1223 2004REFN ISSN 0261-4189PMID 15014436DOI 10.1038/SJ.EMBOJ.7600166 Variant Set Distributions Ripley’s […]
General Structure Information 1kiv LPA recombinant kringle iv-10/m66 variant of human apolipoprotein(a) 2.1Å AUTH I.MOCHALKIN,B.CHENG,O.KLEZOVITCH,A.M.SCANU,AUTH 2 A.TULINSKYTITL RECOMBINANT KRINGLE IV-10 MODULES OF HUMANTITL 2 APOLIPOPROTEIN(A): STRUCTURE, LIGAND BINDINGTITL 3 MODES, AND BIOLOGICAL RELEVANCE.REF BIOCHEMISTRY V. 38 1990 1999REFN ISSN 0006-2960PMID 10026282DOI 10.1021/BI9820558 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3lco CSF1R inhibitor bound to a dfg-out structure of the kinase domain of csf-1r 3.4Å AUTH M.J.MEYERS,M.PELC,S.KAMTEKAR,J.DAY,G.I.PODA,M.K.HALL,AUTH 2 M.L.MICHENER,B.A.REITZ,K.J.MATHIS,B.S.PIERCE,M.D.PARIKH,AUTH 3 D.A.MISCHKE,S.A.LONG,J.J.PARLOW,D.R.ANDERSON,A.THORARENSENTITL STRUCTURE-BASED DRUG DESIGN ENABLES CONVERSION OF A DFG-INTITL 2 BINDING CSF-1R KINASE INHIBITOR TO A DFG-OUT BINDING MODE.REF BIOORG.MED.CHEM.LETT. V. 20 1543 2010REFN ISSN 0960-894XPMID 20137931DOI 10.1016/J.BMCL.2010.01.078 Variant Set Distributions Pathogenic […]
General Structure Information 3kqs PNMT crystal structure of hpnmt in complex adohcy and 2-aminobenzimidazole 2.0Å AUTH N.DRINKWATER,H.VU,K.M.LOVELL,K.R.CRISCIONE,B.M.COLLINS,AUTH 2 T.E.PRISINZANO,S.A.POULSEN,M.J.MCLEISH,G.L.GRUNEWALD,AUTH 3 J.L.MARTINTITL FRAGMENT-BASED SCREENING BY X-RAY CRYSTALLOGRAPHY, MS ANDTITL 2 ISOTHERMAL TITRATION CALORIMETRY TO IDENTIFY PNMTTITL 3 (PHENYLETHANOLAMINE N-METHYLTRANSFERASE) INHIBITORS.REF BIOCHEM.J. V. 431 51 2010REFN ISSN 0264-6021PMID 20642456DOI 10.1042/BJ20100651 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1i0e CKM crystal structure of creatine kinase from human muscle 3.5Å AUTH Y.Q.SHEN,L.TANG,H.M.ZHOU,Z.J.LINTITL STRUCTURE OF HUMAN MUSCLE CREATINE KINASE.REF ACTA CRYSTALLOGR.,SECT.D V. 57 1196 2001REFN ISSN 0907-4449PMID 11517911 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2jdf CRYGB human gamma-b crystallin 1.7Å AUTH H.EBERSBACH,E.FIEDLER,T.SCHEUERMANN,M.FIEDLER,AUTH 2 M.T.STUBBS,C.REIMANN,G.PROETZEL,R.RUDOLPH,U.FIEDLERTITL AFFILIN-NOVEL BINDING MOLECULES BASED ON HUMANTITL 2 GAMMA-B-CRYSTALLIN, AN ALL BETA-SHEET PROTEIN.REF J.MOL.BIOL. V. 372 172 2007REFN ISSN 0022-2836PMID 17628592DOI 10.1016/J.JMB.2007.06.045 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3q6n HSP90AA1 crystal structure of human mc-hsp90 in p21 space group 3.05Å AUTH C.C.LEE,T.W.LIN,T.P.KO,A.H.-J.WANGTITL THE HEXAMERIC STRUCTURES OF HUMAN HEAT SHOCK PROTEIN 90REF PLOS ONE V. 6 19961 2011REFN ESSN 1932-6203PMID 21647436DOI 10.1371/JOURNAL.PONE.0019961 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants