General Structure Information
| PDB ID | 1fik |
| HGNC Gene Label(s) | PFN1 |
| Structure Name | human platelet profilin i crystallized in low salt |
| Resolution | 2.3Å |
| Reference | AUTH A.A.FEDOROV,T.D.POLLARD,S.C.ALMOTITL CRYSTAL STRUCTURE OF HUMAN PROFILIN AT 2.0TITL 2 ANGSTROMS RESOLUTIONREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 139 |
| Number Of SNVs | 15 |
| Number Of Permutations | 5221 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.19 |
| p-value | 0.357 |
ClinVar
| Number Of Residues | 139 |
| Number Of SNVs | 4 |
| Number Of Permutations | 545 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.167 |
| p-value | 0.115 |
COSMIC
| Number Of Residues | 139 |
| Number Of SNVs | 3 |
| Number Of Permutations | 129 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.333 |
| p-value | 0.243 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 15 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.514 |
| p-value | 0.094 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 15 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.324 |
| p-value | 0.39 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
