Assessment of Structural Intolerance and Durability
General Structure Information 3azn HIST1H2BJ crystal structure of human nucleosome core particle containing h4k91q mutation 3.0Å AUTH W.IWASAKI,H.TACHIWANA,K.KAWAGUCHI,T.SHIBATA,W.KAGAWA,AUTH 2 H.KURUMIZAKATITL COMPREHENSIVE STRUCTURAL ANALYSIS OF MUTANT NUCLEOSOMESTITL 2 CONTAINING LYSINE TO GLUTAMINE (KQ) SUBSTITUTIONS IN THE H3TITL 3 AND H4 HISTONE-FOLD DOMAINSREF BIOCHEMISTRY V. 50 7822 2011REFN ISSN 0006-2960PMID 21812398DOI 10.1021/BI201021H Variant Set Distributions Ripley’s K […]
General Structure Information 2vdy SERPINA6 crystal structure of the reactive loop cleaved corticosteroid binding globulin complexed with cortisol 2.3Å AUTH A.ZHOU,Z.WEI,P.L.STANLEY,R.J.READ,P.E.STEIN,R.W.CARRELLTITL THE S-TO-R TRANSITION OF CORTICOSTEROID-BINDING GLOBULINTITL 2 AND THE MECHANISM OF HORMONE RELEASE.REF J.MOL.BIOL. V. 380 244 2008REFN ISSN 0022-2836PMID 18513745DOI 10.1016/J.JMB.2008.05.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1r1j MME structural analysis of neprilysin with various specific and potent inhibitors 2.35Å AUTH C.OEFNER,B.P.ROQUES,M.C.FOURNIE-ZALUSKI,G.E.DALETITL STRUCTURAL ANALYSIS OF NEPRILYSIN WITH VARIOUS SPECIFIC ANDTITL 2 POTENT INHIBITORS.REF ACTA CRYSTALLOGR.,SECT.D V. 60 392 2004REFN ISSN 0907-4449PMID 14747736DOI 10.1107/S0907444903027410 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1bla FGF2 basic fibroblast growth factor (fgf-2) mutant with cys 78 replaced by ser and cys 96 replaced by ser, nmr -1.0Å AUTH F.J.MOY,A.P.SEDDON,P.BOHLEN,R.POWERSTITL HIGH-RESOLUTION SOLUTION STRUCTURE OF BASICTITL 2 FIBROBLAST GROWTH FACTOR DETERMINED BYTITL 3 MULTIDIMENSIONAL HETERONUCLEAR MAGNETIC RESONANCETITL 4 SPECTROSCOPY.REF BIOCHEMISTRY V. 35 13552 1996REFN ISSN 0006-2960PMID 8885834DOI 10.1021/BI961260P Variant […]
General Structure Information 3bu6 INSR crystal structure of the insulin receptor kinase in complex with irs2 krlb phosphopeptide 1.95Å AUTH J.WU,Y.D.TSENG,C.F.XU,T.A.NEUBERT,M.F.WHITE,AUTH 2 S.R.HUBBARDTITL STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF THETITL 2 KRLB REGION IN INSULIN RECEPTOR SUBSTRATE-2.REF NAT.STRUCT.MOL.BIOL. V. 15 251 2008REFN ISSN 1545-9993PMID 18278056DOI 10.1038/NSMB.1388 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4ilw MMP10 complex of matrix metalloproteinase-10 catalytic domain (mmp-10cd) with tissue inhibitor of metalloproteinases-2 (timp-2) 2.1Å AUTH J.BATRA,A.S.SOARES,C.MEHNER,E.S.RADISKYTITL MATRIX METALLOPROTEINASE-10/TIMP-2 STRUCTURE AND ANALYSESTITL 2 DEFINE CONSERVED CORE INTERACTIONS AND DIVERSE EXOSITETITL 3 INTERACTIONS IN MMP/TIMP COMPLEXES.REF PLOS ONE V. 8 75836 2013REFN ESSN 1932-6203PMID 24073280DOI 10.1371/JOURNAL.PONE.0075836 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4e93 FES crystal structure of human feline sarcoma viral oncogene homologue (v- fes)in complex with tae684 1.84Å AUTH S.HELLWIG,C.V.MIDUTURU,S.KANDA,J.ZHANG,P.FILIPPAKOPOULOS,AUTH 2 E.SALAH,X.DENG,H.G.CHOI,W.ZHOU,W.HUR,S.KNAPP,N.S.GRAY,AUTH 3 T.E.SMITHGALLTITL SMALL-MOLECULE INHIBITORS OF THE C-FES PROTEIN-TYROSINETITL 2 KINASE.REF CHEM.BIOL. V. 19 529 2012REFN ISSN 1074-5521PMID 22520759DOI 10.1016/J.CHEMBIOL.2012.01.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4g1t IFIT2 crystal structure of interferon-stimulated gene 54 2.8Å AUTH Z.YANG,H.LIANG,Q.ZHOU,Y.LI,H.CHEN,W.YE,D.CHEN,J.FLEMING,AUTH 2 H.SHU,Y.LIUTITL CRYSTAL STRUCTURE OF ISG54 REVEALS A NOVEL RNA BINDINGTITL 2 STRUCTURE AND POTENTIAL FUNCTIONAL MECHANISMS.REF CELL RES. 2012REFN ISSN 1001-0602PMID 22825553DOI 10.1038/CR.2012.111 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2uzx MET structure of the human receptor tyrosine kinase met in complex with the listeria monocytogenes invasion protein inlb: crystal form i 2.8Å AUTH H.H.NIEMANN,V.JAGER,P.J.G.BUTLER,J.VAN DEN HEUVEL,AUTH 2 S.SCHMIDT,D.FERRARIS,E.GHERARDI,D.W.HEINZTITL STRUCTURE OF THE HUMAN RECEPTOR TYROSINE KINASETITL 2 MET IN COMPLEX WITH THE LISTERIA INVASION PROTEINTITL 3 INLBREF CELL(CAMBRIDGE,MASS.) V. 130 235 2007REFN […]
General Structure Information 3w14 INSR insulin receptor ectodomain construct comprising domains l1,cr,l2, fniii-1 and alphact peptide in complex with bovine insulin and fab 83-14 4.4Å AUTH J.G.MENTING,J.WHITTAKER,M.B.MARGETTS,L.J.WHITTAKER,AUTH 2 G.K.-W.KONG,B.J.SMITH,C.J.WATSON,L.ZAKOVA,E.KLETVIKOVA,AUTH 3 J.JIRACEK,S.J.CHAN,D.F.STEINER,G.G.DODSON,A.M.BRZOZOWSKI,AUTH 4 M.A.WEISS,C.W.WARD,M.C.LAWRENCETITL HOW INSULIN ENGAGES ITS PRIMARY BINDING SITE ON THE INSULINTITL 2 RECEPTORREF NATURE V. 493 241 2013REFN ISSN 0028-0836PMID 23302862DOI 10.1038/NATURE11781 Variant […]