General Structure Information
| PDB ID | 3azn |
| HGNC Gene Label(s) | HIST1H2BJ |
| Structure Name | crystal structure of human nucleosome core particle containing h4k91q mutation |
| Resolution | 3.0Å |
| Reference | AUTH W.IWASAKI,H.TACHIWANA,K.KAWAGUCHI,T.SHIBATA,W.KAGAWA,AUTH 2 H.KURUMIZAKATITL COMPREHENSIVE STRUCTURAL ANALYSIS OF MUTANT NUCLEOSOMESTITL 2 CONTAINING LYSINE TO GLUTAMINE (KQ) SUBSTITUTIONS IN THE H3TITL 3 AND H4 HISTONE-FOLD DOMAINSREF BIOCHEMISTRY V. 50 7822 2011REFN ISSN 0006-2960PMID 21812398DOI 10.1021/BI201021H |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 95 |
| Number Of SNVs | 27 |
| Number Of Permutations | 3578 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.077 |
| p-value | 0.888 |
COSMIC
| Number Of Residues | 95 |
| Number Of SNVs | 3 |
| Number Of Permutations | 66 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.333 |
| p-value | 0.609 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 27 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.239 |
| p-value | 0.485 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
