Assessment of Structural Intolerance and Durability
General Structure Information 1zy7 ADARB1 crystal structure of the catalytic domain of an adenosine deaminase that acts on rna (hadar2) bound to inositol hexakisphosphate (ihp) 1.7Å AUTH M.R.MACBETH,H.L.SCHUBERT,A.P.VANDEMARK,A.T.LINGAM,AUTH 2 C.P.HILL,B.L.BASSTITL INOSITOL HEXAKISPHOSPHATE IS BOUND IN THE ADAR2TITL 2 CORE AND REQUIRED FOR RNA EDITING.REF SCIENCE V. 309 1534 2005REFN ISSN 0036-8075PMID 16141067DOI 10.1126/SCIENCE.1113150 Variant Set […]
General Structure Information 4md7 CSNK2B crystal structure of full-length symmetric ck2 holoenzyme 3.1Å AUTH G.LOLLI,A.RANCHIO,R.BATTISTUTTATITL ACTIVE FORM OF THE PROTEIN KINASE CK2 ALPHA 2 BETA 2TITL 2 HOLOENZYME IS A STRONG COMPLEX WITH SYMMETRIC ARCHITECTURE.REF ACS CHEM.BIOL. V. 9 366 2014REFN ISSN 1554-8929PMID 24175891DOI 10.1021/CB400771Y Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2vom TPI1 structural basis of human triosephosphate isomerase deficiency. mutation e104d and correlation to solvent perturbation. 1.85Å AUTH C.RODRIGUEZ-ALMAZAN,R.ARREOLA-ALEMON,AUTH 2 D.RODRIGUEZ-LARREA,B.AGUIRRE-LOPEZ,AUTH 3 M.T.DE GOMEZ-PUYOU,R.PEREZ-MONTFORT,M.COSTAS,AUTH 4 A.GOMEZ-PUYOU,A.TORRES-LARIOSTITL STRUCTURAL BASIS OF HUMAN TRIOSEPHOSPHATETITL 2 ISOMERASE DEFICIENCY: MUTATION E104D IS RELATED TOTITL 3 ALTERATIONS OF A CONSERVED WATER NETWORK AT THETITL 4 DIMER INTERFACE.REF J.BIOL.CHEM. […]
General Structure Information 4guk NCS1 new crystal form structure of human ncs1 1.75Å AUTH F.CHENGPENG,L.ELIASTITL NEW CRYSTAL FORM STRUCTURE OF HUMAN NCS1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2oj4 RGS3 crystal structure of rgs3 rgs domain 2.3Å AUTH L.REZABKOVA,E.BOURA,P.HERMAN,J.VECER,L.BOUROVA,M.SULC,AUTH 2 P.SVOBODA,V.OBSILOVA,T.OBSILTITL 14-3-3 PROTEIN INTERACTS WITH AND AFFECTS THE STRUCTURE OFTITL 2 RGS DOMAIN OF REGULATOR OF G PROTEIN SIGNALING 3 (RGS3).REF J.STRUCT.BIOL. V. 170 451 2010REFN ISSN 1047-8477PMID 20347994DOI 10.1016/J.JSB.2010.03.009 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4jvm SULT1E1 crystal structure of human estrogen sulfotransferase (sult1e1) in complex with inactive cofactor pap and brominated flame retardant tbbpa (tetrabromobisphenol a) 1.99Å AUTH R.A.GOSAVI,G.A.KNUDSEN,L.S.BIRNBAUM,L.C.PEDERSENTITL MIMICKING OF ESTRADIOL BINDING BY FLAME RETARDANTS AND THEIRTITL 2 METABOLITES: A CRYSTALLOGRAPHIC ANALYSIS.REF ENVIRON.HEALTH PERSPECT. V. 121 1194 2013REFN ISSN 0091-6765PMID 23959441DOI 10.1289/EHP.1306902 Variant Set Distributions […]
General Structure Information 1n3l YARS crystal structure of a human aminoacyl-trna synthetase cytokine 1.18Å AUTH X.-L.YANG,R.J.SKENE,D.E.MCREE,P.SCHIMMELTITL CRYSTAL STRUCTURE OF A HUMAN AMINOACYL-TRNA SYNTHETASETITL 2 CYTOKINEREF PROC.NATL.ACAD.SCI.USA V. 99 15369 2002REFN ISSN 0027-8424PMID 12427973DOI 10.1073/PNAS.242611799 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1z29 SULT1A2 crystal structures of sult1a2 and sult1a1*3: implications in the bioactivation of n-hydroxy-2-acetylamino fluorine (oh-aaf) 2.4Å AUTH J.LU,H.LI,J.ZHANG,M.LI,M.Y.LIU,X.AN,M.C.LIU,W.CHANGTITL CRYSTAL STRUCTURES OF SULT1A2 AND SULT1A1 *3: INSIGHTS INTOTITL 2 THE SUBSTRATE INHIBITION AND THE ROLE OF TYR149 IN SULT1A2.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 396 429 2010REFN ISSN 0006-291XPMID 20417180DOI 10.1016/J.BBRC.2010.04.109 Variant Set Distributions Ripley’s […]
General Structure Information 3sxs BMX crystal structure of bmx non-receptor tyrosine kinase complexed with pp2 1.89Å AUTH J.MUCKELBAUER,J.S.SACK,N.AHMED,J.BURKE,C.Y.CHANG,M.GAO,AUTH 2 J.TINO,D.XIE,A.J.TEBBENTITL X-RAY CRYSTAL STRUCTURE OF BONE MARROW KINASE IN THE XTITL 2 CHROMOSOME: A TEC FAMILY KINASE.REF CHEM.BIOL.DRUG DES. V. 78 739 2011REFN ISSN 1747-0277PMID 21883956DOI 10.1111/J.1747-0285.2011.01230.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4h3b MAPK10 crystal structure of jnk3 in complex with sab peptide 2.08Å AUTH J.D.LAUGHLIN,J.C.NWACHUKWU,M.FIGUERA-LOSADA,L.CHERRY,AUTH 2 K.W.NETTLES,P.V.LOGRASSOTITL STRUCTURAL MECHANISMS OF ALLOSTERY AND AUTOINHIBITION IN JNKTITL 2 FAMILY KINASES.REF STRUCTURE V. 20 2174 2012REFN ISSN 0969-2126PMID 23142346DOI 10.1016/J.STR.2012.09.021 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants